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Published byLeo Dennis Modified over 9 years ago
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Diphtheria toxin deconstruction
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Motivos: módulos simples de combinaciones de estructura secundaria ( a veces se asocian a una función) Dominios: agrupación de motivos de plegado característico (pueden o no ser unidades de plegado autónomo; pueden o no estar asociados a una función) Estructura terciaria: combinación de dominios
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Tipos de dominios alfa beta alfa+beta alfa/beta
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Motivo: alfa-loop-alfa
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Figure 17: The complexation of calcium in EF hands
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Conservation of calcium binding loop in EF-hand motifs
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Figure 24: Effects of calcium binding of the structure of the EF-hand domain of spectrin
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CRO repressor Motivo: alfa-turn-alfa
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trp repressor
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Leucin_rich repeat
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Human growth hormone Dominio manojo de hélices
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Dominio globina
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myoglobin Dominio globina
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Motivo beta hairpin
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streptococcal protein G
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HLA DQ, una molécula del MHC
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Porine
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Motivo beta-alfa-beta
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TIM barrel:closed Rosmann fold
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fosforibosil antranilato isomerasa +indol glicerol fosfato sintasa
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Flavodoxina: open Rossman fold
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Class Number of foldsNumber of superfamiliesNumber of families All alpha proteins202342550 All beta proteins141280529 Alpha and beta proteins (a/b)130213593 Alpha and beta proteins (a+b)260386650 Multi-domain proteins40 55 Membrane and cell surface proteins428291 Small proteins72104162 Total88714472630 SCOP: Structural Classification of Proteins. 1.67 release 24037 PDB Entries (15 May 2004). 65122 Domains. 1 Literature Reference (excluding nucleic acids and theoretical models)
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Thanks Alberto Podjarny Ermacora
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