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Acute Female Pelvic Pain: U/S Features
Melissa Kern, PGY-4 Courtesy Drs. M. Atri A. Menard, H. Dua
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Introduction Female pelvic pain common presenting complaint in ER radiology TV U/S best first-line imaging modality More SN and SP than CT No radiation or contrast Direct patient contact CT often used in ER setting when pathology still unknown after US and persistent pain or suspected pathology beyond depth probe can reach or bowel pathology as mimicker
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Clinical Relevance A normal pelvic U/S high negative predictive value for serious pelvic pathology.
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Common Causes of ER ♀ Pelvic Pain
Gynecologic Ovarian cyst rupture or hemorrhage PID Ovarian torsion Ectopic pregnancy Non-gynecologic Ureterolithiasis Appendicitis Diverticulitis
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Ovarian Cysts…. the basics
Estrogen phase: follicles are at their smallest (typically < 5mm) By day 10, one dominates and increases in size to about 2-2.5cm (rest regress) LH surge at mid cycle causes mature follicle to rupture and release egg – follicle then normally loses its fluid, rapidly shrinks and becomes corpus luteum
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Ovarian Cysts Pain may occur:
As follicle matures and ovarian capsule is stretched At time of ovulation Due to cyst rupture Dominant follicle fails to expel oocyte the follicle may further enlarge into a cyst Due to cyst hemorrhage After shrinking, CL may internally bleeds and re-expands = hemorrhagic cyst
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Typically reserve the term cyst for structures larger than 2.5-3.0cm
Normal ovarian follicle Simple ovarian cyst – well-defined, anechoic, hypoattenuating Typically reserve the term cyst for structures larger than cm
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TV U/S Findings Ruptured Ovarian Cyst No detectable ovarian cyst
Collapsed cyst Free pelvic fluid (3-5 ml physiologic)
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TV U/S Findings Hemorrhagic Cyst
Typically, complex mass with internal echoes and some degree of through transmission Fresh blood may be anechoic initially In the first 24hrs…. low-level echoes in a fine, lacelike, reticular pattern Solid pelvic mass Amorphous blood clot Echogenic free pelvic fluid The extra-ovarian findings on TVS include echogenic pelvic fluid which may range from a small amount to a large quantity and since blood can be very irritant, even a small amount could be very symptomatic This may be associated with a solid pelvic mass or amorphous blood clot. Ovarian findings vary from no detectable cyst that is ruptured, to a hemorrhagic cyst to a solid mass
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Hemorrhagic Cyst This is a classical example of a hemorrhagic cyst with retracting spider-web like septa. Notice the vascularity in the wall of the cysts. Surprisingly good through transmission cause mostly cystic.
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The Many Faces of Hemorrhagic Cysts
These are three examples of hemorrhagic cysts This is a classical example with spider web like debris The one in the middle is more solid like And the third like more amorphous debris. Notice the presence of peripheral rings in all of them that is highly suggestive of functional cyst
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Vascular Ring Sign Mixed solid cystic hemorrhagic cyst.
Vascularity of the periphery of a mass is a very helpful sign to differentiate a functional mass from an endometrioma or a cancer . Ovarian cancers are not usually predominantly solid (exception: rare granulosa cell tumor). Cystic cancers do not show a vascular ring in the absence of a vascular solid component.
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Retractile clot
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Hemorrhagic Cysts….the Bottom Line
Can be any size and echogenicity Caution in post menopausal women Helpful signs: Vascular ring Through transmission Retractile clot Almost all will resolve within 1-2 menstrual cycles Can be up to 15cm Post menopausal women – 15-20% have small simple cysts <3cm – complexity, growth can be worrisome – short interval FU to exclude ca Pre-menopausal women – if hemorrhagic cyst persists, may be an endometrioma
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Endometrioma ??? Hemorrhagic Cyst
Endometrioma – homo low level internal echoes with through transmission
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Endometrioma Affect ~10% premenopausal women
Complex cystic masses with homogenous low-level echoes or ground glass appearance (due to repeated episodes of cyclic bleeding) Follow-up imaging may be necessary to differentiate endometriomas from hemorrhagic ovarian cysts
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Pelvic Inflammatory Disease
Complication of STDs (chlamydia, gonorrhea) Estimated incidence US – 1 million acute cases per year Can lead to infertility or ectopic pregnancy PID is a clinical and laboratory diagnosis and a negative u/s doesn’t exclude milder forms
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Utility of U/S Determine the extent of disease
Evaluate the non-responders to treatment Follow-up patients post treatment Approach to drain abscesses Although PID is a clinical and laboratory diagnosis and negative US does not exclude it in the mild forms of disease, US is occasionally used for diagnosis But more commonly to determine the extent of disease And response to treatment, especially in non-responders to determine need for US guided intervention or surgery It is also used to follow response to treatment and is an approach to the abscess drainage
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PID: U/S Findings *Thickened vascular fallopian tube (often bilateral)
• Fluid-filled +/- debris (non-specific) • Collapsed Increased volume and indistinct margins of ovaries Adnexal inflamed fat and tenderness Tubo-ovarian abscess Echogenic pelvic fluid The most specific TVS findings is the presence of a thick FT that is usually bilateral. The thick tube may be collapsed, or distended with debris or echogenic material in the case of pyosalpinx The ovaries may be enlarged with indistinct margin because of associated oophoritis In more advanced cases, there is significant fatty inflammation in the adnexa and tuboovarian abscess develops. Different amount of echogenic fluid is usually present Can see fluid/debris filled FT in PID, torsion, ectopic
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Thickened Fallopian Tube
Left fallopian tube in the same patient that is thickened and slightly vascular
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PID OV LEFT FT RIGHT FT
This is an example of PID with bilateral mild thickening of the fallopian tubes. The degree of FT thickening is variable. Remember that the thickened tube is usually located in close proximity to the ovary as in this case and if you do not have a high degree of suspicion and not look for it you may pass it as part of ovary. Moreover, remember that we do not see a normal tube so once you identify a tubular structure it is abnormal and consistent with mild PID. LEFT FT RIGHT FT
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PID OV OV OV RIGHT FT LEFT FT
Another example of PID that shows the tubular nature of the process RIGHT FT LEFT FT
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Pyosalpinx OV RIGHT FT
This is an example of PID with pyosalpinx. So part of the tube is solid looking and thick both on the right and the left side but there is in addition dilatation of the fallopian tube that is full of pus. Again note the proximity of the thick tube to the ovary even causing mass effect on it. RIGHT FT
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Pyosalpinx
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Surrounding inflammation
One point to emphasize is the degree of fat inflammation you see with PID that you do not see with any other gynecological acute abdomen but you also see with other inflammatroy causes such as crohn’s, appendicitis or diverticulitis. Also you may see inflammation of the adjacent bowel that should not detract you from the primary cause. The secondary causes of bowel inflammation affect the outer black muscle layer more than the other layers. Also see surrounding echogenic fat Normal bowel wall thickness less than 5mm
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Ovarian Torsion Partial or complete twist of ovarian pedicle
Venous/lymphatic obstruction ovarian edema arterial compromise ischemia/infarction
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Ovarian Torsion Pre-pubertal ♀: idiopathic
Adults: often associated with benign mass Often present with acute pain + vomiting
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Ovarian Torsion - Treatment
Emergent surgical de-torsion Salvage rates better for ovarian vs. testicular torsion Symptom duration does not always predict viablility Treatment Urgent surgical de-torsion Conservation of ovarian tissue is recommended Oophoropexy is controversial The ovary is sutured to the peritoneum of the posterior abdominal wall, medially Attempt to avoid disturbing the tubo-ovarian anatomic relationship Contralateral oophoropexy is gaining acceptance when unilateral oophorectomy is performed Long term ovarian viability is not guaranteed, even when organ reperfused in OR Salvage rates are better for ovarian torsion than for testicular torsion Length of symptoms prior to evaluation does not always predict viability Gross appearance at surgery is also not predictive of salvage Can both over and under-estimate survival Oral contraceptives commonly prescribed post-operatively
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Presence of Doppler flow does not exclude torsion!
U/S Findings: Twisting (whorl) sign Increased ovarian volume (stromal edema) Multiple small peripheral ovarian cysts Multiple echogenic cysts in the same ovary Free fluid Associated mass Presence of Doppler flow does not exclude torsion! The most specific finding of adnexal torsion is the presence of a twist in the tube presenting as what is called in the literature as whorl sign. However, I find this sign is difficult to appreciate. The sign that I find more sensitive and in the proper context specific is the presence of increased ovarian volume due to stromal edema. Other signs are less specific including ….. The absolute absence of flow is helpful to diagnose torsion but its presence does not exclude it. Twisted ovary is usually more than twice the size of contralateral side
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U/S Findings: Absence or high resistance to arterial flow with absent venous flow, particularly when accompanied by ovarian enlargement is highly suggestive of ovarian torsion
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The “Whorl” Sign This is the whorl sign of torsion. Notice the presence of flow in spite of torsion. In general it is the venous flow that is diminshed first and then arterial flow.
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Ovarian Torsion Enlarged ovary (maximal diameter, >5 cm) with prominent peripheral nonovulatory follicles and a small amount of free fluid (arrow) around the inferior margin.
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Ectopic Pregnancy Implantation of fertilized ovum outside endometrial lining 2% of all pregnancies Leading cause of death during 1st trimester 9-14% mortality rate
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Ectopic Pregnancy Symptoms: 5-9wk hx amenorrhea Mild pelvic pain
Vaginal spotting Asymptomatic (50%)
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Ectopic Pregnancy Risk Factors: Previous hx ectopic pregnancy
Tubal surgery PID Use of IUD Previous c-section IVF Congenital uterine anomalies FT (ampulla or isthmus) most common location, <1% in the ovary, <0.03% abdominal pregnancy Within uterus ectopic pregnancies can occur in cornual region of fundus or cervix Rate of hetero increases with IVF “interstitial” or “cornual” pregnancy is ectopic in prox portion of FT which transverse the uterine wall
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fallopian tubes (95%) Intra-abdominal: 0.03-1%
(12%) (2-4%) (70%) (11%) (1-3%) (<1%) (<1%) Intra-abdominal: % Heterotopic: 1-3% IVF pts FT (ampulla or isthmus) most common location, <1% in the ovary, <0.03% abdominal pregnancy Within uterus ectopic pregnancies can occur in cornual region of fundus or cervix Rate of hetero increases with IVF “interstitial” or “cornual” pregnancy is ectopic in prox portion of FT which transverse the uterine wall fallopian tubes (95%)
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Ectopic Pregnancy - Treatment
Medical (Methotrexate) Hemodynamically stable No evidence of tube rupture (small volume free fluid) ßHCG and size criteria (site specific) Surgical Salpingotomy Salpinectomy US-guided local injection of Methotrexate or KCL Preferred for cornual or cervical ectopics Treatment Medical treatment with methotrexate preferred Patient must be hemodynamically stable No evidence for tube rupture Little or no peritoneal fluid Early, unruptured, small ectopic 90% success rate EP < 4 cm HCG levels < 5,000 mIU/mL ≤ 8 wks gestation 70% success rate if living embryo Multiple doses may be necessary Ultrasound after treatment is often confusing ↑ Hemorrhage around EP ↑ Size of EP Use only if suspect tubal rupture Surgical therapy Salpingectomy Segment of tube removed Ends reconnected if possible Only choice for ruptured EP Salpingotomy Small lengthwise incision in tube Removal of EP Ultrasound guided local injection Methotrexate or potassium chloride (KCl) Injected directly into GS Live ectopic + unruptured tube 30% fail systemic treatment Preferred method for cornual and cervical ectopics
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U/S Criteria Discriminatory level for detecting IUP is ßHCG > 2000
If ßHCG > 2000 and no IUP: EP Early pregnancy failure If ßHCG < 2000 and no IUP: Normal early IUP IUP is evident with serum -hCG > 2000
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U/S Findings Normal IUP:
Intradecidual sign (4.5wks): small collection of fluid eccentrically located within the endometrium Double decidual sign (5wks): 2 concentric hyperechoic rings that surround an anechoic gestational sac Yolk sac (5.5wks): when GS reaches 8mm
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Double decidual sac sign in a normal IUP
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EP: U/S Findings “Pseudogestational sac” sign: No IUP
Normal endometrium Thin-walled decidual cysts (found at junction endo- and myometrium in normal and abnormal pregnancies) “Pseudogestational sac” sign: Thick decidual reaction surround intrauterine fluid (no double decidual sign) Located centrally within endometrial canal 10% patients with EP General Features Best diagnostic clue: No intrauterine pregnancy (IUP) + tubal mass + echogenic cul-de-sac fluid Location: Separate from ovary Morphology Complex adnexal mass From hemorrhage Tubal ring Similar to IUP gestational sac (GS) Ultrasonographic Findings Uterine findings vary Thin endometrium Empty uterus Thick echogenic endometrium Decidual reaction of pregnancy Endometrial cysts Often small and multiple Large cyst may mimic early IUP "Pseudogestational sac" sign Decidual cast Endometrial fluid (blood) Lacks double-decidual sac sign of normal IUP Heterotopic pregnancy (rare) IUP + EP Tubal findings Adnexal abnormality in 80-95% Tubal hematoma (40-60%) Nonspecific mass Heterogeneous echotexture Tubal ring (50%) Echogenic ring separate from ovary +/- Yolk sac +/- Embryo +/- cardiac activity Tubal ring "lights up" with color Doppler "Ring of fire" May show small EP missed otherwise Pulsed Doppler findings High-velocity, low-resistance flow Trophoblastic flow velocity > ovarian velocity > 2-4 kHz common for trophoblastic flow Ovary findings Identify which ovary contains corpus luteum (CL) 85% of ectopics on same side as CL Corpus luteum appearance is variable Echogenic ring Hypoechoic cyst Anechoic cyst Complex cyst from hemorrhage Corpus luteum can mimic EP CL is within ovary and tubal EP is outside of ovary Corpus luteum Doppler findings Similar to "ring of fire" but in ovary CL flow velocity < trophoblastic tissue velocity Low-resistive flow-like EP flow Echogenic fluid in cul-de-sac Blood within peritoneal space Between uterus and rectum Echogenic fluid May need ↑ gain settings to see echoes Small amount of anechoic fluid considered physiologic Clotted blood may be mass-like and complex Blood may be an isolated finding 42% will have EP if small amount of fluid seen 73% will have EP if large amount of fluid seen Role of transabdominal ultrasound Look for upper abdomen fluid Paracolic gutters Morrison pouch (between liver and kidney) Ultrasound completely negative in 5-10% of cases No IUP, normal adnexa, no cul-de-sac fluid Imaging Recommendations Best imaging tool Transvaginal ultrasound + color Doppler 91% of EP accurately diagnosed Protocol advice Correlate findings with human chorionic gonadotropin (hCG) levels Should see IUP when hCG levels are > 2,000 mIU/mL IRP (international reference preparation) Suspect EP if no IUP and hCG > 2,000 mIU/mL IRP Lack of IUP at low hCG levels does not rule out EP EP's have lower hCG levels/gestational age Obtain sagittal cul-de-sac view in every case Transvaginal probe angled towards rectum Adjust gain settings to see echoes Look for CL in every case EP often on same side as CL CL hemorrhage or rupture may be cause of pain Do not confuse CL for EP Use color Doppler Look for small EP Rule out ovarian torsion as cause of pain Use endovaginal probe as a palpation tool Gently wedge probe between mass and ovary Free hand on abdomen palpates same area EP moves independent of ovary CL moves with ovary
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Pseudogestational sac in an ectopic pregnancy
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Transvaginal gray-scale US image obtained along the longitudinal axis shows an intrauterine pseudo–gestational sac (arrow); there is no yolk sac or fetal pole. Free fluid is seen in the cul-de-sac (*).
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EP: U/S Findings Tubal/adnexal mass SEPARATE FROM OVARY
“Tubal ring” sign: hyperechoic ring surround an extra-uterine gestational sac *“Ring of fire” sign: peripheral hypervascularity of hyperechoic ring General Features Best diagnostic clue: No intrauterine pregnancy (IUP) + tubal mass + echogenic cul-de-sac fluid Location: Separate from ovary Morphology Complex adnexal mass From hemorrhage Tubal ring Similar to IUP gestational sac (GS) Ultrasonographic Findings Uterine findings vary Thin endometrium Empty uterus Thick echogenic endometrium Decidual reaction of pregnancy Endometrial cysts Often small and multiple Large cyst may mimic early IUP "Pseudogestational sac" sign Decidual cast Endometrial fluid (blood) Lacks double-decidual sac sign of normal IUP Heterotopic pregnancy (rare) IUP + EP Tubal findings Adnexal abnormality in 80-95% Tubal hematoma (40-60%) Nonspecific mass Heterogeneous echotexture Tubal ring (50%) Echogenic ring separate from ovary +/- Yolk sac +/- Embryo +/- cardiac activity Tubal ring "lights up" with color Doppler "Ring of fire" May show small EP missed otherwise Pulsed Doppler findings High-velocity, low-resistance flow Trophoblastic flow velocity > ovarian velocity > 2-4 kHz common for trophoblastic flow Ovary findings Identify which ovary contains corpus luteum (CL) 85% of ectopics on same side as CL Corpus luteum appearance is variable Echogenic ring Hypoechoic cyst Anechoic cyst Complex cyst from hemorrhage Corpus luteum can mimic EP CL is within ovary and tubal EP is outside of ovary Corpus luteum Doppler findings Similar to "ring of fire" but in ovary CL flow velocity < trophoblastic tissue velocity Low-resistive flow-like EP flow Echogenic fluid in cul-de-sac Blood within peritoneal space Between uterus and rectum Echogenic fluid May need ↑ gain settings to see echoes Small amount of anechoic fluid considered physiologic Clotted blood may be mass-like and complex Blood may be an isolated finding 42% will have EP if small amount of fluid seen 73% will have EP if large amount of fluid seen Role of transabdominal ultrasound Look for upper abdomen fluid Paracolic gutters Morrison pouch (between liver and kidney) Ultrasound completely negative in 5-10% of cases No IUP, normal adnexa, no cul-de-sac fluid Imaging Recommendations Best imaging tool Transvaginal ultrasound + color Doppler 91% of EP accurately diagnosed Protocol advice Correlate findings with human chorionic gonadotropin (hCG) levels Should see IUP when hCG levels are > 2,000 mIU/mL IRP (international reference preparation) Suspect EP if no IUP and hCG > 2,000 mIU/mL IRP Lack of IUP at low hCG levels does not rule out EP EP's have lower hCG levels/gestational age Obtain sagittal cul-de-sac view in every case Transvaginal probe angled towards rectum Adjust gain settings to see echoes Look for CL in every case EP often on same side as CL CL hemorrhage or rupture may be cause of pain Do not confuse CL for EP Use color Doppler Look for small EP Rule out ovarian torsion as cause of pain Use endovaginal probe as a palpation tool Gently wedge probe between mass and ovary Free hand on abdomen palpates same area EP moves independent of ovary CL moves with ovary *non-specific, may also be seen surrounding normal maturing follicle, CL….. confirm that separate from the ovary.
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EP: U/S Findings Echogenic free-fluid in cul-de-sac
U/S completely negative in 5-10% 85% of ectopics on same side as CL Echogenic fluid in cul-de-sac Blood within peritoneal space Between uterus and rectum Echogenic fluid May need ↑ gain settings to see echoes Small amount of anechoic fluid considered physiologic Clotted blood may be mass-like and complex Blood may be an isolated finding 42% will have EP if small amount of fluid seen 73% will have EP if large amount of fluid seen Role of transabdominal ultrasound Look for upper abdomen fluid Paracolic gutters Morrison pouch (between liver and kidney) Ultrasound completely negative in 5-10% of cases No IUP, normal adnexa, no cul-de-sac fluid Imaging Recommendations Best imaging tool Transvaginal ultrasound + color Doppler 91% of EP accurately diagnosed Protocol advice Correlate findings with human chorionic gonadotropin (hCG) levels Should see IUP when hCG levels are > 2,000 mIU/mL IRP (international reference preparation) Suspect EP if no IUP and hCG > 2,000 mIU/mL IRP Lack of IUP at low hCG levels does not rule out EP EP's have lower hCG levels/gestational age Obtain sagittal cul-de-sac view in every case Transvaginal probe angled towards rectum Adjust gain settings to see echoes Look for CL in every case EP often on same side as CL CL hemorrhage or rupture may be cause of pain Do not confuse CL for EP Use color Doppler Look for small EP Rule out ovarian torsion as cause of pain Use endovaginal probe as a palpation tool Gently wedge probe between mass and ovary Free hand on abdomen palpates same area EP moves independent of ovary CL moves with ovary These are some tips to localize EP. Identify ovary first. This prevents mistaking ovary for EP EP is usually closely related to ovary Once EP is located and if it is close to the ovary confirm ….. Start looking for EP without color Doppler. The flashing form Doppler prvents seeing small EPs
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EP vs. CLC CLC EP The most difficult task when we are looking for EP is to distinguish an ovary or corpus luteum cyst of ovary from an EP. Here one of these two structures is CLC and one EP. In general the two have similar features. Both show a rind around the cyst. Although the rind of the EP is more echogenic there is overlap. Echogenic rind is tubal ring Here this is an EP and this a CLC
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EP vs. CLC This is an example of an EP sitting next to the ovary that contains a cyst. In this case the one on your right is the EP and the one on your left is the ovary. In general EP has a more echogenic rind than CLC but this is a soft finding and I do not recommend using this sign. This is why I emphasize that you need to find the ovary first and then look for an extraovarian mass in its vicinity. This EP has a sac in it but less than 70% of the EPs have a sac and the other 30% or more look solid. Vascularity does not help since there is overlap between the two. Extreme vascularity is more often seen in EP than CLC but in those cases the grayscale makes the diagnosis. There is also overlap between the Doppler values of CLC and EP as well. CLC EP
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EP vs. CLC Similar flow
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Ring of Fire
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Tubal Ectopic CLC EP EP can look more solid
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Acute pelvic pain and + ßHCG is EP until proven otherwise!
In a women of reproductive age with no established IUP. . .
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Follow-up Average doubling time ßHCG in a normal, viable IUP is ~48hrs
If no IUP, no ectopic identified in ßHCG +’ve ♀, suggest serial ßHCG and f/u u/s as clinically indicated In EP’s serum HCG levels rise at much slower rate
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Case 1 PID
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Case 2 This is an example of a ruptured hemorrhagic cyst which is bascially the combination of echogenic, septated as in this case or solid looking pelvic blood and a hemorrhagic cyst. Again this is a classical hemorrhagic cyst. Note the fine septa in this cyst that you do not see in any other condition. Please remember that in a number of cases, the hemorrhagic cyst is not visible because it is completely drained. Also, the amount of pelvic blood is variable and it could be very small amount and be very painful. On real-time exam. The point of maximum tenderness helps recognizing the small amount of blood as the source of pain.
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Case 3 TVUS, positive beta greater than 2000
CLC is on left of image and EP on right This is an example of a more solid looking HSX mimicking a more solid looking CLC. Again both show peripheral vascularity and low RI
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Case 4 Whorl sign, edematous enlarged ovary with decreased flow and large ovarian cyst.
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Case 5 Hemorrhagic ovarian cyst. Transverse transvaginal US image of the adnexa shows a complex hemorrhagic cyst with the characteristic lacelike echogenic pattern of fibrin strands that form as blood clots and retracts.
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Case 6 Endometrioma. Longitudinal transvaginal US image of the adnexa depicts a large, well-defined, complex cystic mass with low-level internal echoes.
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Case 7 Pelvic inflammatory disease with a tuboovarian abscess. (a) Transverse transvaginal US image of the pelvis reveals bilateral dilated folding tubular structures with thickened walls, internal echogenic fluid, and debris. (b) Axial contrast-enhanced CT image shows dilated tubular structures with thick enhancing walls. Inflammatory stranding of the surrounding fat is most demonstrable on the right (arrow). The presence of a tuboovarian abscess was confirmed at surgery.
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Case 8 Transvaginal gray-scale US image of the right adnexa reveals an extraovarian adnexal mass with a hyperechoic tubal ring (arrow). A tubal pregnancy was confirmed at surgery. OV = right ovary.
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Case 9 Lt ureteric calculus
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