1. National Institute on Drug Abuse P rescription D rug A buse: An Escalating Public Health Threat P rescription D rug A buse: An Escalating Public Health Threat

2. Current (Past Month) Use of Prescription Drugs for Non-Medical Purposes 2007 National Survey on Drug Use and Health Source: SAMHSA, NSDUH 2007

4. Source: SAMHSA, The Dawn Report: Narcotic Analgesics, 2002 Update, September 2004

5. Source: SDI Health, VONA and SAMHSA, DAWN 2002, 2008 DAWN Update

6. Source: SAMHSA, NSDUH 2007

7. CESAR FAX January 19, 2009, Vol. 18, Issue 2. Adapted by CESAR from University of Michigan, “Trends in 30-Day Prevalence of Use of Various Drugs in Grades 8, 10, and 12,”Monitoring the Future study, 2008.

8. Percent of 12th Graders Reporting Nonmedical Use of OxyContin and Vicodin in the Past Year Remained High Source: University of Michigan, 2008 Monitoring the Future Study *No year-to-year differences are statistically significant.

9. Source: University of Michigan, 2008 Monitoring the Future Study Prevalence of Past Year Drug Use Among 12 th Graders Percent of 12 th Graders

10. Age in Years Source: SAMHSA, NSDUH 2007

12. Between 1999 and 2005 there was a near doubling of unintentional poisoning deaths mainly from opioid analgesic abuse Between 1994 and 2004 there was a 300% increase in treatment admissions for opioids other than heroin (as primary abused drug)

15. Find the Balance: Reduce suffering for patients with pain Increase awareness of the abuse potential of opioid medications NIDA is working to engage primary care physicians and dentists as our partners in recognizing, preventing & treating drug abuse Find the Balance: Reduce suffering for patients with pain Increase awareness of the abuse potential of opioid medications NIDA is working to engage primary care physicians and dentists as our partners in recognizing, preventing & treating drug abuse

16. SDI Health, LLC –Collects data from a representative sample of pharmacies, payers, and other third party data providers (over 99% of pharmacies captured) –As of 2006 over 56,100 pharmacies nationwide VONA: Vector One National –Each month, nearly 50% of the retail prescriptions dispensed are collected and projected through methods that stratify by geography, pay type and class of trade –Trend data available for prescription counts from 1991 TPT: Total Patient Tracker –Projects the unique number of patients taking a therapy or multiple therapies over time –Patient based data available as of 2002

17. Opioids Include Codeine & Comb NON-INJ (USC 02232), Morphine & Opium NON-INJ (USC 0222), Morphine & Opium INJ (USC 0221), Codeine & Comb INJ (USC 02231). Source: SDI Health, TPT 2008 09-29-08 Opiates and US Census

18. Opioids Include Codeine & Comb NON-INJ (USC 02232), Morphine & Opium NON-INJ (USC 0222), Morphine & Opium INJ (USC 0221), Codeine & Comb INJ (USC 02231). Source: SDI Health, TPT 2008 09-29-08 Opiates and US Census

19. Opioids Include Codeine & Comb NON-INJ (USC 02232), Morphine & Opium NON-INJ (USC 0222), Morphine & Opium INJ (USC 0221), Codeine & Comb INJ (USC 02231). Source: SDI Health, TPT 2008 09-29-08 Opiates and US Census

20. Opioids Include Codeine & Comb NON-INJ (USC 02232), Morphine & Opium NON-INJ (USC 0222), Morphine & Opium INJ (USC 0221), Codeine & Comb INJ (USC 02231). Source: SDI Health, VONA 2008 11-12-08 Opiates

22. Annual school survey by the University of Michigan funded by NIDA –12 th graders since 1975 –8 th and 10 th graders since 1991 2008 Sample: –386 public and private schools –46,348 students Questionnaires are administered to students in their classrooms

23. Annual nationwide survey funded by SAMHSA –Includes civilian, noninstitutionalized population aged 12 years old or older residing within the United States 2007 survey –Respondent sample of 67,870 persons representative of the U.S. general population aged 12 or older (since 1991, the civilian, noninstitutionalized population) Data collection –In-person computer assisted interviews with sample persons, incorporating procedures that would be likely to increase respondents' cooperation and willingness to report honestly about their illicit drug use behavior