1. PROF.T.BAVANISANKAR.

3.  CHRONIC BALANOPOSTHITIS  LEUCOPLAKIA OF GLANS  LONGSTANDING GENITAL WARTS  PAGET’S DISEASE OF PENIS(ERYTHROPLASIA OF QUERAT)  CONDYLOMA ACUMINATA(HPV)  BALANITIS XEROTICA OBLITERANS  HIV & SEXUALLY TRANSMITTED DISEASES

4.  Squamous cell carcinoma  Non squamous carcinomas : Basal cell carcinoma Adenocarcinoma Melanoma Sarcoma Metastases Paget’s disease

8.  INFILTRATING TYPE  PAPILLIFEROUS TYPE  ULCERATIVE TYPE HISTOPATHOLOGY :  Squamous cell ca 59%  Papillary ca 15%  Baseloid 10%  Warty 10%  Verrucous ca 3%  Sarcomatoid 3%

9.  Buck’s fascia – temporary natural barrier  Spread of tumour – Local invasion Lymphatic spread Metastasis(liver,lung, bone,brain)

10.  GLANS – 48%  PREPUCE – 21%  CORONA – 6%  SHAFT – 2%

11.  EARLY SYMPTOMS – MILD DISCOMFORT, SLIGHT DISCHARGE  RECENT ONSET PHIMOSIS  LATER – LARGE GROWTH WITH SECONDARY INFECTION – FOUL SMELLING PURULENT AND BLOODY DISCHARGE  URETHRAL FISTULA - RARE  SIXTY PERCENT – INGUINAL LYMPHNODE ENLARGEMENT – REACTIVE ENLARGEMENT

12.  Penile lesion assess site size fixation Involvement of corpora  Bilateral inguinal node examination  Per rectal and bimanual examination for perineal body involvement and presence of pelvic metastasis

13.  Prepuce & shaft skin – superficial inguinal nodes  Glans, shaft & corona - superficial inguinal nodes deep inguinal nodes pelvic nodes  Multiple cross-connections at all levels – hence penile lymphatic drainage is bilateral

14.  BLOOD INVESTIGATIONS  EDGE BIOPSY  FNAC OF INGUINAL LYMPH NODES  USG – corpora cavernosal involvement  MRI-TUMOUR SPREAD

15.  STAGE I – tumour involving glans or prepuce  STAGE II – tumour - body of penis  STAGE III – mobile inguinal nodes  STAGE IV – adjacent structures or fixed nodes

18.  Glans involvement – partial amputation of penis

19.  2 cm proximal to the tumor  Urethrostomy is created by approximating the urethra to the surrounding penile skin  Atleast 2cms of shaft should remain  Goal is to preserve  Voiding in standing posture  Sexual function

20. TOTAL PENECTOMY A, Incision. B, Transection of the corpora near the level of the pubis. C, Mobilization of the remaining urethra off of the proximal corporal bodies. D, Transposition of the urethra through a curvilinear perineal incision. E, Completion of perineal urethrostomy.

22. T1 Negative Positive 4 weeks of antibiotics, Observe reassess Negative Positive Follow high risk algorithm

23. T2-T4, Any T with vascular invasion Any T, Grade III Bilateral Negative Unilateral positive Bilateral positive Mobile < 4cms Mobile < 4cms Bilateral Superficial Inguinal Dissection OR Next slide Next slide Complete Modified Dissection Frozen Section Positive Ipsilateral Deep Inguinal and pelvic node dissection Negative Observe

24. Unilateral Positive Mobile < 4cms Ipsilateral Inguinal(Superficial+Deep) and pelvic node with Contralateral Superficial Inguinal Dissection Frozen Section Positive Negative Deep Inguinal Observe and pelvic node dissection

25. Bilateral Positive Mobile < 4cms FNAC Negative Positive Follow bilateral Bilateral Ilio-inguinal negative algorithm dissection Adjuvant Chemotherapy

27.  Carbon Dioxide (CO 2 )  Neodymium:yttrium-aluminum-garnet (Nd:YAG)  Potassium titanyl phosphate (KTP) Circumcision is usually recommended at the time of laser surgery if not already done Indications  Carcinoma insitu  T1 lesions  T2 lesions if patient refuses aggressive surgery

28. Advantages  Good cosmesis  Erectile function not altered in 72% Disadvantages  Exact depth of laser coagulation cannot be assessed  Large lesions cannot be managed  Healing difficulties in obese and immuno- comprised patients

29.  Carcinoma in situ,T1 lesions  Advanced inoperable tumour  Postoperative RT to inguinal region  advanced fixed inguinal nodes

30. Requisites for Radiotherapy  Circumcision or Dorsal slit – to expose the lesion  Resolution of any surface infection – to prevent maceration & preputial edema Treatment modalities  External beam therapy  Electron beam therapy  Radium mold  Silicon mold  Interstitial therapy(Radium 226,Iridium 192,Cesium 137) Dosage – 5000 to 5700 rads over 3 weeks

31.  Penile necrosis – 10%  Urethral stricture – 30%  Sensory loss  Erectile dysfunction  Testicular damage  Secondary neoplasms

32.  Bleomycin – radiosensitiser-based regimens  5 FU,METHOTREXATE,BLEOMYCIN,CISPLATIN, VINCRISTINE VBM(Vincristine,Bleomycin,Methotrexate) MBP(Methotrexate,Bleomycin,Cisplatin)