1. HUMORAL AND CELL-MEDIATED IMMUNITY
Lucija Klobučar, 2nd year
2013/2014
Mentor: A. Žmegač Horvat

2. IMMUNITY
Lat. immunitas – freedom from
Immune system

3. LEVELS OF IMMUNE RESPONSE
INNATE IMMUNITY
SPECIFIC IMMUNITY
external barriers
phagocytic cells
humoral
cell-mediated IF
NOT!
ANTIGEN

4. EXAMPLE

5. CELLS OF SPECIFIC IMMUNITY

6. ANTIGEN-PRESENTING CELLS
Macrophages (bacteria)
Dendritic cells
(viruses)
B lymphocytes
(toxins)
In tissues
Phagocyte and degrade
Display on cell surface
Enter lymph
In lymph nodes
Interaction with T helper cells
DECISION
cytokines, type of presenting cell
Humoral or cell-mediated immune response

7. HUMORAL OR CELL MEDIATED IMMUNE RESPONSE?
BACTERIA
B cells
HUMORAL RESPONSE
VIRUSES
Cytotoxic T cells
CELL- MEDIATED RESPONSE

8. INTERACTION OF T HELPER CELL AND RESTING
HUMORAL IMMUNITY
B cells – develop in bone marrow – blood, lymph, lymph nodes
Primary follicle with resting B lymphocytes
Secondary follicle with activated B lymphocytes
Plasma cells
Memory
B cells
Secrete immunoglobulins
Circulate
INTERACTION OF T HELPER CELL AND RESTING
B LYMPHOCYTES
Antigen-presenting cell – lymph node –
interaction with T helper cells

9. IMMUNOGLOBULINS Five classes – IgA, IgD, IgE, IgG, IgM
Lymph node – circulation – inflamed tissue – recognition of antigen – activation of complement system
Opsonizing
antigen
Enhancing inflammation

10. CELL-MEDIATED IMMUNITY
T cells – development in bone marrow and thymus
Selection
Differentiation
T helper cells
T cytotoxic cells
Circulate

11. CELL-MEDIATED IMMUNITY
Antigen-presenting cell – lymph node –
interaction with T helper cells
Resting cytotoxic T cells
INTERACTION OF T HELPER CELL AND RESTING CYTOTOXIC T CELL
Activated and multiplied cytotoxic T cells enter blood and lymph
In inflamed tissue
Recognition and lysis of cells infected with viruses

12. REFERENCES Roitt, Delves Roitt's Essential Immunology, 10th edition
Andreis, Batinić, Čulo, Grčević, Lukinović-Škudar, Marušić, Taradi, Višnjić Imunologija, 7. izdanje