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HUMORAL AND CELL-MEDIATED IMMUNITY

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Presentation on theme: "HUMORAL AND CELL-MEDIATED IMMUNITY"— Presentation transcript:

1 HUMORAL AND CELL-MEDIATED IMMUNITY
Lucija Klobučar, 2nd year 2013/2014 Mentor: A. Žmegač Horvat

2 IMMUNITY Lat. immunitas – freedom from Immune system

3 LEVELS OF IMMUNE RESPONSE
INNATE IMMUNITY SPECIFIC IMMUNITY external barriers phagocytic cells humoral cell-mediated IF NOT! ANTIGEN

4 EXAMPLE

5 CELLS OF SPECIFIC IMMUNITY

6 ANTIGEN-PRESENTING CELLS
Macrophages (bacteria) Dendritic cells (viruses) B lymphocytes (toxins) In tissues Phagocyte and degrade Display on cell surface Enter lymph In lymph nodes Interaction with T helper cells DECISION cytokines, type of presenting cell Humoral or cell-mediated immune response

7 HUMORAL OR CELL MEDIATED IMMUNE RESPONSE?
BACTERIA B cells HUMORAL RESPONSE VIRUSES Cytotoxic T cells CELL- MEDIATED RESPONSE

8 INTERACTION OF T HELPER CELL AND RESTING
HUMORAL IMMUNITY B cells – develop in bone marrow – blood, lymph, lymph nodes Primary follicle with resting B lymphocytes Secondary follicle with activated B lymphocytes Plasma cells Memory B cells Secrete immunoglobulins Circulate INTERACTION OF T HELPER CELL AND RESTING B LYMPHOCYTES Antigen-presenting cell – lymph node – interaction with T helper cells

9 IMMUNOGLOBULINS Five classes – IgA, IgD, IgE, IgG, IgM
Lymph node – circulation – inflamed tissue – recognition of antigen – activation of complement system Opsonizing antigen Enhancing inflammation

10 CELL-MEDIATED IMMUNITY
T cells – development in bone marrow and thymus Selection Differentiation T helper cells T cytotoxic cells Circulate

11 CELL-MEDIATED IMMUNITY
Antigen-presenting cell – lymph node – interaction with T helper cells Resting cytotoxic T cells INTERACTION OF T HELPER CELL AND RESTING CYTOTOXIC T CELL Activated and multiplied cytotoxic T cells enter blood and lymph In inflamed tissue Recognition and lysis of cells infected with viruses

12 REFERENCES Roitt, Delves Roitt's Essential Immunology, 10th edition
Andreis, Batinić, Čulo, Grčević, Lukinović-Škudar, Marušić, Taradi, Višnjić Imunologija, 7. izdanje


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