1. MUSCLE STRUCTURE AND PHYSIOLOGY J. Rosenbluth, April 2009

2. MUSCLE Skeletal muscle –Contraction mechanism –Excitation-contraction coupling Gross properties of skeletal muscle Cardiac, obliquely striated and smooth muscles Pathology/Clinical examples

3. Skeletal muscle band pattern

4. Double “antiparallel” array of myofilamnts (H.E.Huxley)

5. Sliding filament model

6. Myosin molecules

7. Myosin filament formation

8. Low-angle X-ray diffraction of skeletal muscle (meridional pattern)

9. Actin double helix

10. Decorated F-actin

11. Decorated F-actin attached to Z-disc

12. Double hexagonal array (vertebrate skeletal muscle)

13. Low-angle X-ray diffraction of skeletal muscle (equatorial pattern)

14. Crossbridge position during relaxation (top) vs contraction (bottom)

15. Cross-bridge Cycle –Attached –Released –Cocked –Force generating –Attached

17. Focal contraction (amphibian skeletal muscle)

18. Triads (amphibian)

19. Skeletal muscle triad (amphibian)

20. Triad model (Franzini-Armstrong, C.)

21. Actin filament with Tr and Tm

22. Tropomyosin movement

24. Pennate Muscles

25. Length-Tension Relationship

26. Load-Velocity Relationship

27. Twitch vs Tetanic Tension

28. Cat Gastrocmenius

29. Muscles Have Heterogenous Properties Twitch Contractions

30. Skeletal Muscle Fatigue

32. Cardiac muscle

33. Obliquely striated muscle (Ascaris), stretched

34. Ascaris obliquely striated muscle

35. Smooth muscle (“Myoelastic tissue”)

36. Smooth muscle (cross section)

37. Smooth muscle (Science 148:1337-1339)

38. Smooth muscle

39. ABRM

43. “Pseudohypertrophy” (Duchenne dystrophy)

44. Charcot-Marie-Tooth disease

45. Spinal muscular atrophy