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Published byValentine Jenkins Modified over 9 years ago
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Resveratrolo
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Ligand Induces a Conformational Change in the LBD that Repositions helix 12 No LigandAgonist
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NR Antagonists Alter the Position of Helix 12 No Ligand Agonist (ER) Antagonist (ER)
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PHENOL OH >100,000 Compounds>100,000 Compounds classified according to basic skeletal structureclassified according to basic skeletal structure acidicacidic Participates in oxidation- reduction reactionsParticipates in oxidation- reduction reactions
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Polyphenol content Total polyphenols Red grape, ave. 5500 mg/kg Red wine 700–4000 mg/L White grape, ave. 4000 mg/kg White wine 150-400 mg/L
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Quercetin, catechin, resveratrol Vascular benefits Quercetin, catechin, resveratrol Inhibition of platelet aggregation Inhibition of platelet aggregation Inhibition of LDL oxidation (plaque) Inhibition of LDL oxidation (plaque) Vasodilation Inhibition of vasoconstriction (tannins)
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Anti-carcinogenic properties Stilbenes inhibit cell proliferation Stilbenes inhibit cell proliferation Association with decreased colon cancer Association with decreased colon cancer Inhibition of non-melanoma skin cancer -resveratrol Inhibition of non-melanoma skin cancer -resveratrol Estrogenic effect-resveratrol +/- Estrogenic effect-resveratrol +/-
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Resveratrolo
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