1. Notes : Blood
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2. Volume and Composition
Varies due to:
Size
Hydration
Body composition
8% of body weight
About 5 Liters
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3. Figure 14.3
Page 531
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4. “Hemocytoblast”: -Type of stem cell -Red bone marrow Magette
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5. Red Blood Cells -”Erythrocytes” -95% of cellular blood Magette
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6. -<5% of cellular blood
Platelets
-”Thrombocytes”
-<5% of cellular blood
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7. -<1% of cellular blood
White Blood Cells
-”Leukocytes”
-<1% of cellular blood
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8. Magette
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9. Erythrocytes “Red Cells” 95% of cellular blood Bi-Concave disc
Non-nucleated
Hemoglobin
1/3 of volume
4-7 million/mm3
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10. Erythrocytes
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11. How Much Did You Give?
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12. How Much Did You Give? 4-7 million RBC’s /mm3 of blood Magette
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13. How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL
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14. How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL
You gave 1 pint
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15. How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL
You gave 1 pint
1 pint = mL
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16. How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL
You gave 1 pint
1 pint = mL
4,000,000 x 100 x = 189,280,000,000
7,000,000 x 100 x = 331,240,000,000
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17. How Much Did You Give? 4-7 million RBC’s /mm3 of blood 1 mm3 = 100 mL
You gave 1 pint
1 pint = mL
4,000,000 x 100 x = 189,280,000,000
7,000,000 x 100 x = 331,240,000,000
You gave Billion erythrocytes!
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18. Hemoglobin 1/3 of RBC volume Globular protein Magette
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19. Hemoglobin 1/3 of RBC volume Globular protein
“Heme” groups containing iron
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20. Hemoglobin 1/3 of RBC volume Globular protein
“Heme” groups containing iron
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21. Hemoglobin 1/3 of RBC volume Globular protein
“Heme” groups containing iron
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22. Hemoglobin 1/3 of RBC volume Globular protein
“Heme” groups containing iron
Carries oxygen
Similar to myoglobin
Responsible for red color of blood
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23. Questions:
Is blood sometimes blue?
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24. Questions: Is blood sometimes blue?
How does this relate to what we know about iron-deficiency anemia?
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25. Questions: Is blood sometimes blue?
How does this relate to what we know about iron-deficiency anemia?
How do the CSI people get DNA from blood?
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26. RBC Production Red Bone Marrow
“Erythropoiesis”
Red Bone Marrow
Erythropoietin: hormone released from kidneys and liver that stimulates production of RBC’s
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27. Control of RBC Production
Negative Feedback:
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28. Control of RBC Production
Negative Feedback:
1.Trigger
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29. Control of RBC Production
Negative Feedback:
1.Trigger
2.Hormone Release
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30. Control of RBC Production
Negative Feedback:
1.Trigger
2.Hormone Release
3.Result
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31. Control of RBC Production
Negative Feedback:
1.Trigger
2.Hormone Release
3.Result
4.Inhibition
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32. Control of RBC Production
Negative Feedback:
1.Trigger
2.Hormone Release
3.Result
4.Inhibition
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33. Magette
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34. RBC Breakdown Liver and spleen RBC is destroyed by macrophages
Hemoglobin is broken down into “heme” groups and globular proteins
Proteins are broken down to amino acids and metabolized
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35. RBC Breakdown Heme group is broken down into iron and biliverdin
Iron is stored and/or reused
Biliverdin is converted to orange pigment (bilirubin)
“Bilis-” are secreted in bile
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36. Leukocytes
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37. Thrombocytes
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38. Plasma
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39. Plasma
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40. Plasma
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41. Plasma
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