1. LEVERAGING EXTERNAL INTELLIGENCE Jenny Brown, Director, Oakland Innovation

2. Content Introduction Why do you need to tap into the external world Best practice tools and techniques The benefits of scouting Case Study 1 – Network Mapping Case Study 2 – Beetroot Juice

3. Content Introduction Why do you need to tap into the external world Best practice tools and techniques The benefits of scouting Case Study 1 – Network Mapping Case Study 2 – Beetroot Juice

4.  Founded in 1989 in Cambridge UK  Serving international corporations across the globe  Long-term relations (many 10+ years)  Majority of projects are repeat business  Working on both technical and market projects  Extensive experience in a range of industry sectors  Foods and Beverages  Health and Medical  Beauty  Consumer Products  Chemicals and Materials  Petrochemicals  Harness external knowledge and opinion to explore and evaluate market propositions, find and evaluate technology options, and identify innovation partners Oakland Innovation Ltd

5. The Team and the Skills  An international team of 50+ scientists and engineers  Technically very strong  Commercial experience  Fast learners, quick thinkers and good listeners  Cultural diversity  Linguistic skills  Trained to connect with most relevant experts and engage in ‘intelligent discussions’ around often complex issues and problems  Integrate, build and make sense of the learning  Derive insights and solutions to support and accelerate client’s innovation projects

6. Some of Oakland’s Team

7. Content Introduction Why do you need to tap into the external world Best practice tools and techniques The benefits of scouting Case Study 1 – Network Mapping Case Study 2 – Beetroot Juice

8. Open Innovation CLOSED –All the smart people work for me –Must discover, develop and ship to create value –Need to create most ideas –Control IP OPEN –We need to leverage smart people, wherever they are –Can create value by leveraging the work of others –Need to use best ideas –Need to maximize value of IP – ours and others 8 Henry Chesbrough, 2003, Open Innovation. Harvard Business School Press

9. Commercial Imperative 9 Open Innovation offers economic advantage; especially when funding and resources are less easy to access MARKET

10. Content Introduction Why do you need to tap into the external world Best practice tools and techniques The benefits of scouting Case Study 1 – Network Mapping Case Study 2 – Beetroot Juice

11. Why scout? What are the benefits? Increase the diversity of ideas Speed up innovation Reduce the risk of missing opportunities Increase your chances of placing the right bet 11

12. Content Introduction Why do you need to tap into the external world The benefits of scouting Best practice tools and techniques Case Study 1 – Beetroot Juice Case Study 2 – Network Mapping

13. 13 INTERMEDIARIES CAN HELP YOU

14. Why Use Intermediaries Objectivity Anonymity Skill Set Efficiency 14

15. Some Tools……. Ecosystem Mapping TREE Oakland’s 3As matrix™

16. Content Introduction Why do you need to tap into the external world Best practice tools and techniques The benefits of scouting Case Study 1 – Network Mapping Case Study 2 – Beetroot Juice

17. Existing client ecosystem Speaking terms Active collaboration

18. Proposed new ecosystem Speaking terms Active collaboration

19. Content Introduction Why do you need to tap into the external world Best practice tools and techniques The benefits of scouting Case Study 1 – Network Mapping Case Study 2 – Beetroot Juice

20. Beetroot for Heart Health Example landscaping study

21. The Original Stimulus Is there merit in the idea of a beetroot health or sports beverage? Is there any substance in the report?Are there products already out there? Who could we work with? The Want

22. Overview of health benefits of beetroot 22

23. How does it work? 23

25. Summary of clinical trials InstituteAreaFindingReference William Harvey Research Institute, UK Heart healthFindings demonstrate dose- dependent decreases in blood pressure and vasoprotection after inorganic nitrate ingestion in the form of either supplementation or by dietary elevation. Hypertension, 2010, 56, 274-281. William Harvey Research Institute, UK Heart healthFindings demonstrate acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite Hypertension, 2008, 51, 3, 784-790. University of Exeter, UK Exercise physiology – heart function Dietary nitrate supplementation reduces the O 2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. Journal of Applied Physiology, 2009, 107, 4, 1144-1155 University of Exeter, UK Exercise physiology – heart function Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. Journal of Applied Physiology, 2010, 109, 1, 135-148. 25 All 4 of the human trials used beetroot juice and focused on the benefits of nitrate

26. Overview of patents A total of 14 patents concerning beetroot were found in the areas of food, beverage and healthcare. The majority of the patents make no direct reference to heart health 26

27. KEY EXPERTS

28. Andrew Jones University of Exeter, UK Leads the laboratory of bioenergetics and human performance at the School of Sports and Health Sciences –http://sshs.exeter.ac.uk/researchgroups/bhp/http://sshs.exeter.ac.uk/researchgroups/bhp/ Research interests Respiratory physiology Muscle oxidative metabolism Limitations to endurance exercise performance Clinical trials Dietary nitrate supplementation reduces the O 2 cost of low-intensity exercise and enhances tolerance to high- intensity exercise in humans. Journal of Applied Physiology, 2009, 107, 4, 1144-1155. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. Journal of Applied Physiology, 2010, 109, 1, 135-148. 28

29. Amrita Ahluwalia William Harvey Research Institute, UK Professor of Vascular Pharmacology at Centre for Clinical Pharmacology –http://www.whri.qmul.ac.uk/staff/Ahluwalia.htmlhttp://www.whri.qmul.ac.uk/staff/Ahluwalia.html Research Interests Mechanisms of vascular homeostasis in inflammation and particularly the role of the endothelium The effect of beetroot juice on circulating nitrate and nitrite levels and blood pressure in normotensives and hypertensives Clinical trials Inorganic nitrate supplementation lowers blood pressure in humans: Role for nitrite-derived NO. Hypertension, 2010, 56, 274-281. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension, 2008, 51, 3, 784- 790. 29

30. Mark T. Gladwin, MD University of Pittsburgh, USA Chief of the Pulmonary, Allergy and Critical Care Medicine Division Director of the Hemostasis and Vascular Biology Research Institute –http://www.dept- med.pitt.edu/paccm/faculty/Gladwin.htmlhttp://www.dept- med.pitt.edu/paccm/faculty/Gladwin.html Research Interests Nitrite as a circulating storage pool for NO bioactivity A novel physiological function for hemoglobin as an electronically and allosterically-regulated nitrite reductase The characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction Review Nitrite mediates cytoprotection after ischemia/ reperfusion by modulating mitochondrial function. Basic Research in Cardiology, 2009, 104, 2, 113-119. 30

31. PRODUCTS

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33. Conclusions Beet-based products are an emerging trend Significant research carried out in the past 2 years –However, the jury is still out on palatability and digestibility issues Interesting to monitor growth and evolution of the market More clinical evidence is needed 33

34. In Summary…….. 34

35. Overview Why do you need to tap into the external world? –The bulk of knowledge exists outside your organisation How –WANT, FIND, GET, MANAGE The benefits of external scouts –Speed –Efficiency –Anonymity

36. And Finally……. "When you have exhausted all possibilities, remember this. You haven‘t” Thomas Edison 36