1. Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification,Metformin Treatment, or Standard Care in the Diabetes Prevention Program Featured Article: Linda M. Delahanty, M.S., R.D., Qing Pan, Ph.D., Kathleen A. Jablonski, Ph.D., Karol E. Watson, M.D., Ph.D., Jeanne M. McCaffery, Ph.D., Alan Shuldiner, M.D., Steven E. Kahn, M.B., ChB., William C. Knowler, M.D., Dr.PH, Jose C. Florez, M.D., Ph.D., Paul W. Franks, Ph.D., M.Phil, M.S., FOR THE DIABETES PREVENTION PROGRAM RESEARCH GROUP* Diabetes Care Volume 35:363–366 February, 2012

2. Study Objective To test genetic associations with weight loss and weight regain in the Diabetes Prevention Program Delahanty L et al. Diabetes Care 2012;35:363-366

3. Study Design 16 obesity-predisposing SNPs tested for association with short- term (baseline to 6 months) and long-term (baseline to 2 years) weight loss and weight regain (6 months to study end). Delahanty L et al. Diabetes Care 2012;35:363-366

5. Conclusion Genetic information may help identify people who require additional support to maintain reduced weight after clinical intervention Delahanty L et al. Diabetes Care 2012;35:363-366