2. Arm Rehabilitation Device Orthometrix, Inc. 5621 Strand Avenue, Suite 111 Naples, FL 34110 sales@orthometrix.com Office (914) 694-5946 Fax (914) 694-2286 www.orthometrix.com

3. Objective:  Introducing the Tailwind: A New Arm Rehabilitation Device What does the Tailwind do? Who can benefit from the Tailwind? Why is Tailwind the best choice for patients?  Stroke Facts  Unmet needs for arm rehabilitation  History of the Tailwind – why and how it came to be?  Evidence based data: fact or fiction?  Is Tailwind right for your patients?

4. Orthometrix, Inc. 5621 Strand Avenue, Suite 111 Naples, FL 34110 sales@orthometrix.com Office (914) -5946 Fax (914) 694-2286 www.orthometrix.com

5. STROKE U.S. FACTS : Every 40 seconds someone has a stroke Effects 750,000 Americans a year > 5,500,000 currently live with disabilities associated with stroke Fastest growing age group is 45 – 57 years 85% suffer paralysis on one side 44% of stroke survivors say arm movement is their most common physical challenge, even after therapy U.S. FACTS: Challenges patients face:

6. A Stroke Survivors Journey What is the next step? STROKE Hospital Acute Stroke Treatment In-patient/ Out-patient Physical/ Occupational Therapy Home/ Assisted Living

7. RECOVERY What we know Reorganization in central motor networks occurs during initial recovery from hemiparetic stroke. (Unfortunately, recovery often remains incomplete) Specific rehabilitation therapy can improve upper extremity function even in chronically impaired stroke survivors Tailwind rehabilitation therapy significantly improves ARM function. BATRAC induces reorganization in motor networks which is associated with gains in arm function. A.R.Luft JAMA 10/2004

8. Active lifestyles Recovery from a stroke means younger patients returning to work Today’s seniors can resume full, healthy and lively schedules Patients demand recovery… Tailwind can help!

9. Tailwind transforms the lives of stroke and other brain injury survivors by improving their arm movement and allowing them to regain their independence

10. Introducing TAILWIND Unique, first-of-its-kind, research-based stroke rehabilitation device Bilateral Arm Training with Rhythmic Auditory Cueing Effective in moderate-to-severe patients who have lost upper extremity function due to stroke or other brain injury (tumors, traumatic brain injury, cerebral palsy) Trials included recent stroke survivors 20 years Medical exercises device with progressive ranges of motion, challenging elevations, and gravity free planes A metronome provides beneficial sound / visual cues Proven Convenient Independence-focused Affordable

11. DEVELOPED by Scientists and PhD Researchers Developed by scientist and PhD researchers at the University of Maryland School of Medicine, Department of Physical Therapy and Rehabilitative Science Inventers: Dr. Jill Whitall and Dr. Sandy McCombe Waller PhD Physical Therapists specializing in stroke. Engineered with an understanding of arm muscles and stroke damage Over a decade of research and tests were conducted in order to perfect the Tailwind device Scientific Advisory Board-Daniel F. Hanley, MD, Encore Path Chief Medical Officer; Vice Chairman of the Board, National Stroke Association; and Director, Brain Injury Outcomes Program, Johns Hopkins Medicine

12. Science and Technology Based on leading research into neural plasticity and motor cortex activation Bilateral Arm movement induces re-organization in contralesional motor networks (fMRIs ) Repetitive and controlled movement activates the motor cortex helping the brain to unmask new neural pathways – retrain the brain Notable for showing “neuro- plasticity”- recovery of brain function in recent and years after a stroke

13. Published Studies Repetitive Bilateral Arm Training with Rhythmic Auditory Cueing Improves Motor Function in Chronic Hemiparetic Stroke. Stroke 2000; 31:2390-2395. Whitall J, et al, Repetitive Bilateral Arm Training and Motor Cortex Activation in Chronic Stroke, JAMA, October 20, 2004, Vol 292, No. 15 1853-1861. Luft A, et al, Studies show that patients who use Tailwind BATRAC have improved upper extremity function and range of motion fMRIs show that Tailwind BATRAC induces re-organization in contralesional motor networks

14. Repetitive Bilateral Arm Training and Motor Cortex Activation in Chronic Stroke: A Randomized Controlled Trial JAMA. 2004; 292(15):1853-1861 (doi:10.1001/jama.292.15.1853 ) Andreas R. Luft; Sandy McCombe-Waller; Jill Whitall ; et al. Six week randomized control trial using fMRI to document re-organization in central motor networks TAILWIND Bilateral Training demonstrated re-organization in contralesional motor networks This re-organization was not demonstrated in those who under-took SDMTE controlled therapy 70% of Tailwind patients showed BATRAC – 1 hours therapy sessions (4-5 min periods with10 min interspersed rest i mprovement vs. std physical periods) 3 x/wk for 6 weeks vs..Std DMTE-neurodevelopmental principles- thoracic therapy exercise spine & scapular mobilization, weight bearing with paretic arm opening a closed fist

15. OUTCOMES MEASURING TOOLS Repetitive Bilateral Arm Training and Motor Cortex Activation in Chronic Stroke: Functional Magnetic Resonance Imaging fMR I- Two axial sections at different z coordinates representing changes of activation are shown. Areas of yellow orange indicate increased activation after bilateral arm training with rhythmic auditory cueing (BATRAC); areas of green would indicate increased activation in control patients but none were detected Functional outcome assessed using arm function scores. Upper extremity motor function was measured with Fugl-Meyer Motor Performance Test (upper-extremity portion) ~assesses the ability to isolate movements at each joint and the influence of unwanted synergies on movement Wolf Motor Arm Test (WMAT ) measures functional ability. University of Maryland Arm Questionnaire for Stroke (UMAQS). a self-reported questionnaire that assesses the daily use of the paretic arm in accomplishing activities of daily living

16. Functional Magnetic Resonance Imaging – fMRI Images Before and After Intervention During Motion of the Paretic Arm Areas of yellow orange indicate increased activation after bilateral arm training with rhythmic auditory cueing (BATRAC); areas of green would indicate increased activation in DMTE control patients but none were detected

17. fMRI Images of Nine BATRAC Patients-Before and After Intervention During Motion of the Paretic Arm 6 out of 9 patients showed increased Activation and Functional Outcomes Functional data showed significantly greater increases in Fugl-Meyer scores in BATRAC group than DMTE * patient’s that responded 1,2,3,5,6,8 *data excludes 3 non-responders # 4,7,9 #1 #3 #4 #6 #7 #9

18. Tailwind’s proven efficacy Improves arm function and range of motion Provides results in as little as six weeks Patients 6 months-20 years post stroke experienced improvement Potential for improvement in patients who have reached a plateau Patients often report “feeling” their upper extremity muscles w/in days Documented/measureable progress for neuromuscular re-education Controlled, Repetitive Bilateral Rhythmic Arm Trainer

19. Patient Testimonials Norris – severe stroke 8 years prior to using Tailwind  Motivated patient, uses Tailwind 3-5 times per week  Recently returned to golfing & gardening Patient Debora, 47-year-old masseuse  Clinical trial patient  Returned to work “I can play golf again!”

20. TAILWIND Device Easy to set up and operate Exercise 30 minutes a day, 3 times a week Designed for home or rehab facilities Use independently or with the aid of a caregiver or therapist Durable, lightweight (23 lbs), portable - great for travel and work Variety of challenging/motivational exercises

21. TAILWIND ARM REHABILITAION DEVICE Available Now To Patients and Rehabilitation Facilities Worldwide Fax, mail, or email Tailwind order form to Orthometrix, Inc. 445 Hamilton Avenue, Suite 1102 White Plains, NY 10601 P 914-694-5946 F 914-694-2286 www.orthometrix.net To receive additional information on: Clinical trials, frequently asked questions, Tailwind patient blogs, product videos, patient self test, device specifications, testimonials, and Tailwind history Please visit our Tailwind-dedicated website at www.tailwindtherapy.com or call 410-790-8255

22. Tailwind transforms the lives of stroke and other brain injury survivors by improving their arm movement and allowing them to regain their independence.

23. The Gold Standard in Arm Rehabilitation TAILWIND (tayl-wind) n. Increases the object's speed and reduces the time required to reach its destination

24. Tailwind’s Patient Benefits : Improves arm function and range of motion Provides results in as little as six weeks Exercise only 30 minutes a day, 3 times a week Designed for patients to use at home or in a rehabilitation facility Can be used independently or with the aid of a caregiver or therapist Portable, easy to set up with challenging and creative exercises Rhythmic auditory cueing from a metronome No prescription necessary Provides the possibility of improvement for patients who have reached a plateau Patients experiencing improved arm mobility ranged from a recent stroke - 20 years post-stroke

25. Tailwind’ s Therapy and Rehab Benefits: Created and designed to improve stroke patient’s outcomes The device's success in studies was notable for showing "neuro-plasticity" – recovery of brain function in recent and years after a stroke Documented and measurable progress allows rehabs to retain patients longer as they continue to see improvements in arm therapy- neuromuscular re-education Tailwind’s time saving benefits allows quick turnover therapy sessions Tailwind is durable and easy to operate making the device uniquely suited for all facilities regardless of size or number of patients treated Tailwind provides outcomes rehabs and patients desire Tailwind is cost-effective and a valuable tool for arm improvement

26. For Further Information Orthometrix, Inc. 445 Hamilton Avenue, Suite 1102 White Plains, NY 10601 P (914) 694-5946 F (914) 694-2286 sales@orthometrix.net www.orthometrix.net

27. TAILWIND SUCCESS Countries where Tailwind has been purchased The United StatesCanada JapanSpain KoreaItaly TaiwanGreece Hong KongEngland SingaporeScotland MalaysiaThe Netherlands AustraliaIsrael U pdated 2014

28. Tailwind Tailwind is the best choice for survivors of stoke and other brain injuries who want to improve movement of their arms and become more independent. Tailwind is a medical rehabilitation device that has been proven effective in published clinical studies, can be used easily by patients in their own homes, is the most cost effective solution on the market today, and can improve quality of life. Tailwind's primary medical innovation is controlling the independent movement of the arm by reactivating central neuromuscular pathways, with dormant pathways being reactivated after repetitive use. With several weekly sessions over a 6 week period, there is marked improvement in movement and function in patients, even those who are as much as 20 years post-stroke or other brain injury. Tailwind’s key benefit to patients is improving their arm and upper body mobility and strength, which allows them to resume simple daily tasks and lead more independent lives, with results that are durable and lasting.

29. TAILWIND’S BENEFITS TAILWIND’S Rehabilitation Facility Benefits: Tailwind was created and designed to improve stroke patient’s outcomes Tailwind’s efficacy provides proven and measurable success The device's success in studies was notable for showing "neuro-plasticity" - recovery of brain function in recent stroke victims and those who suffered a stroke years ago Tailwind’s well documented patient progress, neuromuscular re-education, allows rehabilitation facilities to retain patients longer as they continue to see improvements in arm therapy Tailwind’s time saving benefits allow fast turnover in patient therapy sessions Tailwind works by using a Repetitive Bilateral Arm Training with Rhythmic Auditory Cueing Tailwind is durable, easy to operate and portable making the device uniquely suited for all facilities regardless of size or number of patients treated The FDA has classified the Tailwind as an exercise device The Tailwind is a cost-effective rehabilitation device providing great value and will pay for itself quickly - fast delivery

30. TAILWIND’S BENEFITS TAILWIND’S Patient Benefits: Improves arm function and range of motion Provides results in as little as six weeks Exercise only 30 minutes a day, 3 times a week Designed for patients to use at home or in a rehabilitation facility Can be used independently or with the aid of a caregiver/therapist Non-invasive, portable, easy to set up and operate No prescription necessary Provides the possibility of improvement for patients who have reached a plateau Patients experiencing improved arm mobility ranged from a recent stroke - 20 years post-stroke Challenging elevation and rotation ranges for flexible and creative exercise routines Hand strap to assist grasp, metronome for “sound to brain” neural pathway retraining method, instructional DVD, detailed owner’s manual, and motivating progress tracking charts Innovative design inspires patients to get moving

31. Arm Rehabilitation Device Thank you!