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Sarah Cohen Boulakia, Christine Froidevaux, Emmanuel Waller Bernard Labedan Université Paris Sud, Orsay Laboratoire de Recherche en Informatique, UMR CNRS.

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Presentation on theme: "Sarah Cohen Boulakia, Christine Froidevaux, Emmanuel Waller Bernard Labedan Université Paris Sud, Orsay Laboratoire de Recherche en Informatique, UMR CNRS."— Presentation transcript:

1 Sarah Cohen Boulakia, Christine Froidevaux, Emmanuel Waller Bernard Labedan Université Paris Sud, Orsay Laboratoire de Recherche en Informatique, UMR CNRS 8623 Institut de Génétique et de Microbiologie, UMR CNRS 8621 A database of modules present in microbial proteomes

2 S. Cohen Boulakia, Ch. Froidevaux, E. Waller (LRI) and B. Labedan (IGM) Evolution of E. coli paralogous proteins modules Biological concept Biological concept o Homologous modules in E. coli Aims Aims o Finding out all modules o Grouping homologous modules in families

3 S. Cohen Boulakia, Ch. Froidevaux, E. Waller (LRI) and B. Labedan (IGM) Evolution of E. coli paralogous proteins Needs Needs o Storing the data o Querying Biological concept Biological concept o Homologous modules in E. coli Aims Aims o Finding out all modules o Grouping homologous modules in families

4 S. Cohen Boulakia, Ch. Froidevaux, E. Waller (LRI) and B. Labedan (IGM) Evolution of E. coli paralogous proteins Database o Database Schema o DataBase Management System : File Maker Pro Web Site Web Site www-colipage.igmors.u-psud.fr Needs Needs o Storing the data o Querying Biological concept Biological concept o Homologous modules in E. coli Aims Aims o Finding out all modules o Grouping homologous modules in families

5 S. Cohen Boulakia, Ch. Froidevaux, E. Waller (LRI) and B. Labedan (IGM) Biological concept Biological concept o Homologous modules o Measuring evolutionary distance separating species Needs Asking very expressive queries Providing graphical representation Now ? How to go from one genome to several genomes ? paraloguesorthologues Aims Aims o Finding out all modules o Grouping homologous modules in families data Storing Storing o very complex o very numerous

6 S. Cohen Boulakia, Ch. Froidevaux, E. Waller (LRI) and B. Labedan (IGM) We want to deal with… Current DBMS Current Database Schema Out of dateHowever… Nanoarchaeota Methanobacteria Spirochaetales Nitrospirae Salmonella Photorhabdus

7 S. Cohen Boulakia, Ch. Froidevaux, E. Waller (LRI) and B. Labedan (IGM) Nanoarchaeota Methanobacteria Spirochaetales Nitrospirae Salmonella Photorhabdus

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