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Vertebrate Embryonic Patterning 5 Neural Crest. Neural Crest Cells.

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Presentation on theme: "Vertebrate Embryonic Patterning 5 Neural Crest. Neural Crest Cells."— Presentation transcript:

1 Vertebrate Embryonic Patterning 5 Neural Crest

2 Neural Crest Cells

3 Neural Crest Derivatives Two major divisions Cranial Trunk PNS Endocrine Melanocytes Facial Cartilage Connective Tissue

4 Trunk Neural Crest

5 Neural Crest Cells Stain Positive for ECM Protein HNK-1 RhoB HNK-1

6 Migratory Pathways of Neural Crest ephrins expressed in posterior compartment of somite

7 Ephrin – Eph RTK Pathway Regulates NC Migration Through/Over Somites Eph RTKs and ephrins appear to regulate boundary formation and cell-cell interactions in many regions of the embryo

8 Ephrins Repulse Axon Growth

9 Signals from the Floorplate Induce Axon Migration

10 Netrin Induces Commissural Axon Growth

11 Semaphorins Repulse Axons

12 Axonal Guidance in Invertebrates

13 Eph RTK & Ephrins Regulate Retinotectal Patterning

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