2. VACCINOLOGY JEOPARDY! 2010

3. 200 300 400 500 100 200 300 400 500 100 200 300 400 500 100 200 300 400 500 100 200 300 400 500 100 ConceptsFacts ApplicationDefinitions Tie- Breakers

4. Antibodies can be produced against almost any substance… TRUE OR FALSE? 1-1-Q

5. TRUE 1-1-A

6. The more similar a vaccine is to the natural pathogen, the better the immune response to the vaccine… TRUE OR FALSE? 1-2-Q

7. TRUE 1-2-A

8. All vaccines present modified/selected antigen(s) that induce an immune response without causing INFECTION… TRUE OR FALSE? 1-3-Q

9. FALSE 1-3-A

10. Humoral and cell-mediated immune responses CANNOT occur at the same time… TRUE OR FALSE? 1-4-Q

11. FALSE 1-4-A FALSE

12. Which of the following statements are true of acquired, but not innate immunity? (a) Involves cytokines and complement (b) Can be induced by vaccine (c) Key mechanism is to prevent injury and death from infection (d) Gets stronger over time 1. a and c 2. b and d 3. a, b, and c 1-5-Q

13. 2. b and d 1-5-A

14. Some antibodies coat organisms, making them more readily ingested by phagocytes… TRUE OR FALSE? 2-1-Q

15. TRUE 2-1-A

16. T-cell independent responses usually produce immunological memory? TRUE OR FALSE? 2-5-Q

17. FALSE 2-5-A

18. What type of response is depicted here? (a) T-cell independent (b) T-cell dependent 2-4-Q IgM B B B*B* B*B* B*B* B*B*

19. (a) T-cell independent 2-4-A

20. Factors that affect the immune response include: (a) Route of vaccine administration (b) Presence of maternal antibody (c) Characteristics of the antigen (d) Host’s nutritional status 1. b, c, and d 2. b and c 3. a, b, c, and d 2-3-Q

21. 3. a, b, c & d 2-3-A

23. Functions of the complement system include: (a) cell lysis (b) attracting phagocytes to the site of inflammation (c) coating antigens to make them more susceptible to phagocytosis (d) promoting inflammation 1. a, b, c, & d 2. a, b & c 3. a & d 2-2-Q Daily Double

24. 1. a, b, c & d 2-2-A

25. Interruption of a series of vaccinations does not require starting the series over again, regardless of the interval elapsed. TRUE OR FALSE? 3-3-Q

26. TRUE 3-3-A

27. If two live parenteral vaccines are given 14 days apart, the vaccine that was given first should be repeated 28 days later. TRUE OR FALSE? 3-1-Q

28. FALSE 3-1-A

29. A live oral vaccine and a live injectable vaccine must be administered on the same day or one month apart. TRUE OR FALSE? 3-4-Q

30. FALSE 3-4-A

31. What vaccines should NOT be given to a perinatally HIV-infected toddler with a normal CD4 count and no history of opportunistic infections? (a) MMR (b) Varicella (c) Hepatitis B (d) Pneumococcal Conjugate 1. b 2. a and b 3. None of the above 5-4-Q

32. 3. None of the above 5-4-A

33. If a person will be having a splenectomy in 2 week’s time, it is too late to immunize them with the recommended vaccines. TRUE OR FALSE? 5-1-Q

34. FALSE 5-1-A

35. The immunoglobulin that predominates in the secondary immune response (a) IgM (b) IgG (c) IgA (d) IgE 4-5-Q

36. (b) IgG 4-5-A

37. This type of vaccine stimulates B cells without the help of T cells (a) Conjugated polysaccharide vaccine (b) Pure polysaccharide vaccine (c) Recombinant vaccine 4-4-Q

38. (b) Pure polysaccharide vaccine 4-4-A

39. Lymphocytes that mediate cell- mediated immunity are called... (a) T-lymphocytes (b) B-lymphocytes (c) T 4 lymphocytes 4-1-Q

40. (a) T-lymphocytes 4-1-A

41. These are non-antibody proteins that function as chemical messengers that regulate all immune responses. (a) Antigen-presenting cells (APCs) (b) Cytokines (c) Complement 4-2-Q

42. (b) Cytokines 4-2-A

44. A cascade of blood proteins that can destroy foreign or infected cells. (a) Interleukins (b) Complement (c) Natural killer cells 4-3-Q Daily Double

45. (b) Complement 4-3-A

46. Vaccine doses given at less than the recommended interval may result in less than optimal antibody response and should not be counted as part of a primary series. TRUE OR FALSE? 3-2-Q

47. TRUE 3-2-A

48. Simultaneous administration of a passive immunizing agent (E.g. immune globulin) and an inactivated vaccine is not recommended for post exposure prophylaxis. TRUE OR FALSE? 3-5-Q

49. FALSE 3-5-A

50. Inactivated vaccines are not likely to be affected by circulating maternal antibodies. TRUE OR FALSE? 5-3-Q

51. TRUE 5-3-A

52. How do premature infants differ from full term infants in terms of when, after birth, they should be immunized with DTaP-IPV-Hib? (a) They don’t differ – they should be immunized at the same chronological age as full-term infants (b) They should be immunized at the age that adds on for their number of weeks of prematurity (c) They should weigh at least 2000g. 5-5-Q

53. (a) They don’t differ – they should be immunized at the same chronological age as full-term infants 5-5-A

54. Cell-mediated immunity is mediated by B lymphocytes…. TRUE OR FALSE? 5-2-Q

55. FALSE 5-2-A

56. NOTE: Can wager up to full total of team’s points! Final Jeopardy

57. An accelerated, memory immune response to an antigen is also referred to as the _________ response. (a) Anergic response (b) Anamnestic response (c) Arthus response Final Jeopardy

58. (b) Anamnestic response