1. TBLI and HIV

2.  30% of People infected with HIV/AIDS and have latent TB will eventually get active TB (5 -10% /year).In HIV negative 5-10 % during their life.

3. It is known that treatment of latent TB infection(LTBI) or TB preventive therapy, helps to prevent progression to active disease

4.  Isoniazid prevention therapy (IPT ) 6-12 months

5. PREVALENCE OF ACTIVE TB IN PEOPLE WITH HIV WHO HAVE LATENT TB AND TREATED WITH INH FOR 6 MONTHS FROM 2004 -2011 S.mansuri M.HajiabdolbaghiM.Hasibi

6. Inclusion criteria HIV positive who have been treated with INH for 6 months and fallowed up for 1 year after Exclusion criteria Sputum AFB positive during INH prophylaxis CxR or CT compatible with TB Pathology compatible with TB LTBI prophylaxis with other drug except INH

7. Results

8. Table - 1 TST result NumbersPercentTST 56.6463938.5Positive 43.3548929.12Negative 100113867.18 TST was done 55132.81 TST was not done 1679100Sum

9. In this study TST was done in67.2% of all HIV patients in our center. This rate in other studies was between 50 %- 79%

10. TST number Positive number Percent 1128 (M.haji) 63956.6 NA (mohraz) NA25% NA(alavi)NA54.5 NA (Alaee) NA88% NA(Shokoohi)NA39.4

11. In other studies prevalence of TBLI in HIV positive from 25% to 46% is reported.

12. TST Prophylaxis numberpercent 40463.22 INH prophylaxis 22935.83 No INH prophylaxis 6.93 PZA,RIF prophylaxis 639100 Sum Sum

13.  In other studies( WHO.USA. Brasilia) 25%,46% 59.8% HIV positive patient with LTB have received IPT

14. Mean follow up period was 3.5 ( 1.5± 3.5 )

15. PPD+ PPD- INH≥6m INH-INH<6m Cases Number 23022980489 TB cases 6531822 TB%2.623.1422.54/49 TB cases in PPD+ and PPD -

16. Variable Age 57/ 8± 39.75) Sex M 264 (85%) F46 (15%) CD4 10 -1124 ART yes 218(70/3%) yes 218(70/3%) No 92 (29/7%)

17. 76% of our cases had compliance to prophylaxis 76% of our cases had compliance to prophylaxis

18. Mean period of time between IPT to treatment of TB in 6 TB cases was 24.7 months

19.  1672 PPD - No PPD PPD + 489632 551 22 INH+397INH-235 94 80 18 653137 303 230 229Z+R6

20. 134 TB cases PPD - 2216.41 No PPD 3727.61 No IPT 5339.55 PPD+ INH <6 mo 1813. Complete IPT 62.6

21. TB before HIV diagnosis 2216.46 TB after HIV diagnosis 7455.22 TB,HIV same time 3828,35 ART before TB diagnosis 2921.64 ART after TB diagnosis 10587.35 134 TB cases

22. TB after ARV