1. Biomedical R&D Folie (slide) 1 Saratin - mechanism of action vWF Platelet

2. Biomedical R&D Folie (slide) 2 Saratin - mechanism of action vWF Platelet

3. Biomedical R&D Folie (slide) 3 Saratin - mechanism of action Platelet vWF

4. Biomedical R&D Folie (slide) 4 Saratin - mechanism of action vWF Platelet

5. Biomedical R&D Folie (slide) 5 Saratin - mechanism of action Platelet vWF

6. Biomedical R&D Folie (slide) 6 Saratin - mechanism of action vWF Platelet

7. Biomedical R&D Folie (slide) 7 Saratin - mechanism of action Platelet vWF

8. Biomedical R&D Folie (slide) 8 Saratin - mechanism of action Platelet

9. Biomedical R&D Folie (slide) 9 Saratin - mechanism of action

10. Biomedical R&D Folie (slide) 10 Saratin - mechanism of action

11. Biomedical R&D Folie (slide) 11 Saratin - mechanism of action

12. Biomedical R&D Folie (slide) 12 Saratin - mechanism of action

13. Biomedical R&D Folie (slide) 13 Saratin - mechanism of action

14. Biomedical R&D Folie (slide) 14 Saratin - mechanism of action

15. Biomedical R&D Folie (slide) 15 Saratin - mechanism of action

16. Biomedical R&D Folie (slide) 16 Saratin - mechanism of action

17. Biomedical R&D Folie (slide) 17 Saratin - mechanism of action

18. Biomedical R&D Folie (slide) 18 Saratin - mechanism of action

19. Biomedical R&D Folie (slide) 19 Saratin - mechanism of action

20. Biomedical R&D Folie (slide) 20 Saratin - mechanism of action

21. Biomedical R&D Folie (slide) 21 Saratin - mechanism of action

22. Biomedical R&D Folie (slide) 22 Saratin - mechanism of action

23. Biomedical R&D Folie (slide) 23 Saratin - mechanism of action Vessel wall injury exposes collagen to elements of flowing blood.

24. Biomedical R&D Folie (slide) 24 Saratin - mechanism of action

25. Biomedical R&D Folie (slide) 25 Saratin - mechanism of action

26. Biomedical R&D Folie (slide) 26 Saratin - mechanism of action

27. Biomedical R&D Folie (slide) 27 Saratin - mechanism of action

28. Biomedical R&D Folie (slide) 28 Saratin - mechanism of action

29. Biomedical R&D Folie (slide) 29 Saratin - mechanism of action vWF A3 domain binds to collagen.

30. Biomedical R&D Folie (slide) 30 Saratin - mechanism of action

31. Biomedical R&D Folie (slide) 31 Saratin - mechanism of action

32. Biomedical R&D Folie (slide) 32 Saratin - mechanism of action vWF A1 domain targets GP Ib/IX/V receptor of circulating platelets, “tethering” them to the vessel wall.

33. Biomedical R&D Folie (slide) 33 Saratin - mechanism of action

34. Biomedical R&D Folie (slide) 34 Saratin - mechanism of action

35. Biomedical R&D Folie (slide) 35 Saratin - mechanism of action Direct collagen-platelet interactions (GP Ia/IIa, GP VI etc.) anchor and then lead to activation of the tethered platelet.

36. Biomedical R&D Folie (slide) 36 Saratin - mechanism of action

37. Biomedical R&D Folie (slide) 37 Saratin - mechanism of action

38. Biomedical R&D Folie (slide) 38 Saratin - mechanism of action

39. Biomedical R&D Folie (slide) 39 Saratin - mechanism of action

40. Biomedical R&D Folie (slide) 40 Saratin - mechanism of action

41. Biomedical R&D Folie (slide) 41 Saratin - mechanism of action

42. Biomedical R&D Folie (slide) 42 Saratin - mechanism of action

43. Biomedical R&D Folie (slide) 43 Saratin - mechanism of action

44. Biomedical R&D Folie (slide) 44 Saratin - mechanism of action Occlusive thrombus!

45. Biomedical R&D Folie (slide) 45 Saratin - mechanism of action How does saratin interfere with arterial thrombosis?

46. Biomedical R&D Folie (slide) 46 Saratin - mechanism of action

47. Biomedical R&D Folie (slide) 47 Saratin - mechanism of action

48. Biomedical R&D Folie (slide) 48 Saratin - mechanism of action

49. Biomedical R&D Folie (slide) 49 Saratin - mechanism of action

50. Biomedical R&D Folie (slide) 50 Saratin - mechanism of action

51. Biomedical R&D Folie (slide) 51 Saratin - mechanism of action S

52. Biomedical R&D Folie (slide) 52 Saratin - mechanism of action S S

53. Biomedical R&D Folie (slide) 53 Saratin - mechanism of action S S S

54. Biomedical R&D Folie (slide) 54 Saratin - mechanism of action S Saratin binds to collagen, preventing interaction with vWF and hence platelets. S S S

55. Biomedical R&D Folie (slide) 55 Saratin - mechanism of action S S S S

56. Biomedical R&D Folie (slide) 56 Saratin - mechanism of action S S S S

57. Biomedical R&D Folie (slide) 57 Saratin - mechanism of action S S S S

58. Biomedical R&D Folie (slide) 58 Saratin - mechanism of action S S S S

59. Biomedical R&D Folie (slide) 59 Saratin - mechanism of action S S S S

60. Biomedical R&D Folie (slide) 60 Saratin - mechanism of action S S S S

61. Biomedical R&D Folie (slide) 61 Saratin - mechanism of action S S S S

62. Biomedical R&D Folie (slide) 62 Saratin - mechanism of action S S S S

63. Biomedical R&D Folie (slide) 63 Saratin - mechanism of action Saratin acts as a molecular plaster, neutralising platelets BEFORE they adhere and become activated. S S S S