1. Tissue Regenration by local administration of autologeus conditiond Concentrate of Thrombocytes in Orthopedics and Sporttraumatology

2. Thrombocytes concentrates PRP Platelet-rich Plasma Platelet-rich PlasmaP-LRP Platelate leucocyt rich plasma Platelate leucocyt rich plasmaACP Autologeus Conditiond plasma Autologeus Conditiond plasma

3. Thrombocyte with alpha granules, Lysomoe and Delta granules (Dense Bodies)

4. Penetration from Thrombin into Thrombocyte causes releasing of alpha granules and lysosome to infiltration in wound of fracture

5. Growth Factors GF Mechanismus of action PDGF PDGF Platelet devired Growth Factor Platelet devired Growth Factor TGF – ß TGF – ß Transforming Growth Factor Beta Transforming Growth Factor Beta VFGF VFGF Vascular Endothellial Growth Factor Vascular Endothellial Growth Factor EGF EGF Epidermal Growth Factor Epidermal Growth Factor Recurit smoth muscle cell Remodels extracellular matrix Affectes Angiogensis and permealbilty Promotes angiogensis and epithelial cells

6. Endothelial cells migrate as reparing cells to traumatized area

7. Vascular endothelial growth factor (VEGF) stimulates diveloping of new blood vessels

8. Platelet drived factor (PDFG-AB) intensifieds mitogenisis and angiogenesis activates macrophages, stemcells and recriute smoth muscle and connective tissue celles.

9. Transforming Growth Factors Beta (TGF) promotes extraecellular matrix and musculoskletal production

10. Traumatic rupture of anterior cruciate ligament

11. Regeneration 3 months after application of ACP

12. Traumatic rupture of the ligamentum patella

13. Surgical reconstruction and application of ACP

14. Rupture of the medial Mensikus

15. fresh traumatic rupture of the medial meniscus

16. Traumatic rupture of the medial meniscus surgical suture and aplication of ACP

17. Achillodynie

18. MRI of Achillestendon

19. 2 weeks afterwards of ACP application

20. Technique of autologous conditioned plasma

21. Thank you so much for your attention Prof.Dr.med.Y.M-Goudarzi