1. 1 Severity of illness (APACHE II score ≥ 25) stratified by RIFLE category in septic shock 28.3 45.2 58.6 69.9 0 10 20 30 40 50 60 70 80 NoneRiskInjuryFailure RIFLE Category APACHE II Score >25 (%) Bagshaw et al, Intensive Care Med, 2009:35:871-881

2. 2 Cumulative effective antimicrobial therapy following onset of hypotension and associated incidence of AKI.

3. 3 Crude survival for septic shock patients stratified by severity of AKI. Survival Probability 0.00 0.25 0.50 0.75 1.00 020406080100 Time (Days) No AKIRIFLE: Risk RIFLE: InjuryRIFLE: Failure Log-rank, p<0.0001 Bagshaw et al, Intensive Care Med, 2009:35:871-881