1. Alexandra Richardson, PhD, CLP April 2015

2. 2 Clayton Biotechnologies, Inc. is a for-profit company which facilitates the commercialization of medical discoveries made by the Clayton Foundation for Research and its supporting entities. The two-fold mission of the Foundation is to: ►conduct medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind, and ►transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products. The Clayton Foundation for Research is a nonprofit medical research organization in Houston, Texas established in 1933 by Benjamin Clayton.

3. Medical Research at Leading Research Institutions 3 Salk UCSD UT-Austin UT-Southwestern UT-Medical Branch MD Anderson Baylor College of Medicine UTHSC-San Antonio North Carolina State U. of Geneva Medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind

4. Medical Research to Develop Cures 4 Cancer Immunotoxins for targeted cancer therapy Avicin to treat Mantle cell Lymphoma Monoclonal antibodies targeting angiogenesis Engineered proteases Next generation anti-mitotic drugs Fc engineered aglycosylated antibodies CNS & Ophthalmology Stem Cell Therapy for Parkinson’s Disease Modulation of brain stress in neurological diseases Genetic disease models for neurological diseases Gene therapy and peptide therapeutics for AMD Metabolic Diseases Urocortin peptides for diabetes GLP-1 combination therapy Molecular switches in glucose control Serum oxysterols as biomarkers of disease

5. Medical Research to Develop Cures 5 Infectious Diseases Vaccines for Dengue and Chinkungunya Vaccines and diagnostics for Ehrlichioses Autoimmune & Inflammation Engineered proteases Fc engineering of aglycosylated antibodies Cardiology Urocortin peptides and gene therapy for congestive heart failure OCT-TPL diagnostics of human vascular plaques Endometriosis Small molecules targeting SRC OCT Image Guided Laser knife for diagnosis and treatment

6. Examples Leaders in Innovation and Technology 6 Stem Cell Therapy Gene Therapy Protein Engineering, Antibodies and Immunotoxins Neuropeptides

7. Mission Two: To transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products. Collaborations Spin-out companies Licensing Transforming Research Into Products 7

8. Portfolio of Start-up Companies 8

9. Some of Our Other Licensees 9

10. Marketed Products 10 bupivacaine liposome injectable suspension Pain Exparel Morphine liposome injectable suspension Post-operative pain DepoDur Cytarabine liposomes injectable suspension Lymphomatous and solid tumor meningitis Depocyt Cardiac PET Imaging Medical imaging systems for private practices Attrius Neonatal and pediatric imaging system Wide-field digital imaging system for the hospital and clinic Retcam Ehrlichoisis canine Assay for canine vector borne diseases AccuPlex 4 Ataxia diagnostic Assay for Spinocerebellar ataxia type 6 (SCA6) SCA6 Diagnostic tests Functional Intracellular analysis Assay for intracellular function of essential micronutrients FIA

11. Clinical Pipeline 11 Lenti-D Childhood ALD Pre-clinicalPhase IPhase II/III LentiGlobin Beta- thalassemia Pre-clinicalPhase I/II LentiGlobin Sickle cell anemia Pre-clinicalPhase I Retinostat AMDPre-clinicalPhase I Urocortin Congestive Heart Failure Pre-clinicalPhase IPhase II VC-01 Type I Diabetes Pre-clinicalPhase I  -TEA Breast cancerPre-clinicalPhase I Indication Candidate compound Development Stage Partner Available to Partner A Cancer Research Hospital

12. Advanced Pre-clinical Pipeline 12 Indication Candidate compound Development Stage Partner Encorstat Corneal graft rejection Pre-clinicalIND Avicin Mantle Cell Lymphoma Pre-clinicalIND Dengue tetra vaccine Dengue Fever IND package VEGF-rGel Solid Tumors IND package VEGF-rGel AMD Advanced pre-clinical Available to Partner

13. Urocortins and analogues for Diabetes GLP-1 agonist combination therapies for Diabetes Alk4-Fc, a Cripto antagonist for Cancer Granzyme B - a potent payload for antibody drug conjugates (ADC) YESS - engineering of proteases Fc engineered antibodies with specific effector function Filaggrin to treat dermatological disorders TEAD gene and peptide therapies for ocular neovascular disease CRFR1 antagonists - therapeutic for early onset AD Stem cell therapy program for Parkinson's Disease Vaccines and Diagnostics for Ehrlichioses OCT guided laser knife for surgery in small spaces Collaboration and Licensing Opportunities 13

14. One Riverway, Suite 1520 Houston, Texas 77056 713.963.5860 www.claytonbiotech.com arichardson@claytonbiotech.com Conducting and funding research Transferring research into products