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DEANNA DAILEY DR. CHAN’S HUMAN PHYS G BLOCK Why do some allergens effect different people in different ways?

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Presentation on theme: "DEANNA DAILEY DR. CHAN’S HUMAN PHYS G BLOCK Why do some allergens effect different people in different ways?"— Presentation transcript:

1 DEANNA DAILEY DR. CHAN’S HUMAN PHYS G BLOCK Why do some allergens effect different people in different ways?

2 What is an allergic reaction? An allergic response is when an antibody binds to and antigen and irritation occurs. Types of reactions:  Rash or hives  Swelling: epically of the lips, tongue, throat, face  Dizziness  Nausea/ diarrhea  Anaphylaxis http://www.walgreens.com/marketing/library/contents.jsp?do ctype=2&docid=8700 https://mnfoodallergies.wordpress.com/tag/food-allergy-reactions/

3 Steps to an allergic reaction 1. The antigen enters the body 2. MHC binds to the pathogen  These bind to the pathogens as identifiers for the T-cell 3. T-cells trigger B-cells to produce IgE antibodies 4. These antibodies target the specific allergen 5. This releases histamine to battle the allergen causing a reaction. Depending on how sensitized, the genes of the person, or how much histamine is released, the person can have a mild or major reaction. http://www.etetens.com/bi obili/biocourse/allergies.ht ml

4 THERE ARE THREE MAJOR REASONS WHY: EXPOSURE GENETICS SOCIOECONOMIC BACKGROUND Why does allergens effect people differently?

5 1. Exposure Sometimes an environmental event (smoking, infections, exercises, psychosocial alterations) can trigger a susceptible person to start having allergies. The more you are exposed to an antigen, the worse the symptoms can be.  This is why reactions towards: ivy, latex, exc… get worse over time There are more specific antibodies present after many exposures.  Faster combat rate of the histamine http//www.jped.com.br/conteudo/01- 77-06-441/ing_print.htm

6 2. Genetics Major Histocompatability Complex (MHC)  These bind to the pathogens as identifiers for the T-cell  This binding cause activation of the B-cells  The genes that code for the MHC are numerous and located on different chromosomes.  There are also many different variations of the multiple genes.  Just because you are disposed to it, does not mean that you will have the allergy. http://bio1151b.nicerweb.net/Locked/ media/ch43/

7 3. Socioeconomic Background Higher socioeconomic background:  Better quality environment.  Access to medical help. Lower socioeconomic background:  Did dirtier work.  Lived in poorer environmental conditions. Immunity towards allergens was a defense mechanism  Survival of the fittest. Variation in Total and Specific IgE: Effects of Ethnicity and Socioeconomic Status

8 Works Cited Celedon, J. C. "Variation in Total and Specific IgE: Effects of Ethnicity and Socioeconomic Status." PubMed.gov (2005): n. pag. Web. 15 Jan. 2015..http://www.ncbi.nlm.nih.gov/pubmed/15805994 "Allergic Reactions: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. Ed. Stuart I. Henochowicz, David Zieve, and Isla Ogilvie. U.S. National Library of Medicine, 10 May 2014. Web. 23 Jan. 2015..http://www.nlm.nih.gov/medlineplus/ency/article/000005.htm Asthma and Allergy Foundation of America. "IGE'S ROLE IN ALLERGIC ASTHMA." Asthma and Allergy Foundation of America. Asthma and Allergy Foundation of America, 2005. Web. 25 Jan. 2015..http://www.aafa.org/display.cfm?id=8&sub=16&cont=54 Asthma and Allergy Foundation of America. "Asthma and Allergy Foundation of America - Information About Asthma, Allergies, Food Allergies and More!" WHAT CAUSES ALLERGIES. Asthma and Allergy Foundation of America, 2011. Web. 25 Jan. 2015..http://www.aafa.org/display.cfm?id=9&cont=79 Janeway, Charles A., and Jr. "The Major Histocompatibility Complex and Its Functions." Immunobiology: The Immune System in Health and Disease. 5th Edition. U.S. National Library of Medicine, 2001. Web. 26 Jan. 2015..http://www.ncbi.nlm.nih.gov/books/NBK27156/


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