1. BioImaging Track (BIm) http://www.bme-paris.org Track chairs: E. Angelini, PhD (Telecom ParisTech) E. Angelini, PhD (Telecom ParisTech) F. Cloppet, PhD (Univ. Paris Descartes) F. Cloppet, PhD (Univ. Paris Descartes) C. Oppenheim, MD (Univ. Paris Descartes) C. Oppenheim, MD (Univ. Paris Descartes)

2. BME Master 2 – BioImaging Track (BIM) Bioimaging is an exciting field at the interface between Mathematics, computer science, chemistry, physics, life science, biology and medicine. The main goal of Bioimaging is to improve human health using imaging modalities to advance diagnosis, treatment and prevention of human disease.

3. BME Master 2 – BioImaging Track (BIM)

4. Bio Imaging master track (BIM) Complementary skills from:  University Paris Descartes,  Paris Diderot  Engineering schools of ParisTech BIM program:  Fifteen courses (UE) at the M2 level.  Co-organized by faculty members experts in the field. Basic sciences: mathematics, physics, chemistry Applied mathematics: signal& image processing, numerical analysis. Biology and Medicine: diagnostic tools, innovative screening, contrast agents, biomarkers, image-based modeling

5. BioImaging Track Program

6. BioImaging Track Program: Program Content in 2010-2011 Autumn Semester (30 ECTS ) Autumn Semester (30 ECTS )  Interdisciplinary seminar (6 ECTS )  Physics & Technology of Medical Imaging (6 ECTS )  Chemistry for Imaging (6 ECTS )  Medical Image Analysis (6 ECTS )  Molecular Imaging (3 ECTS )  Functional & Metabolism Imaging (3 ECTS )

7. Spring Semester (30 ECTS ) Spring Semester (30 ECTS )  BioEngineering Economy and Industry (3 ECTS )  BioEthics  Research Internship – five months (27 ECTS ) BioImaging Track Program: Program Content in 2010-2011

8. Unit 3.5 Chemistry for Imaging Person(s) in charge:  Y.-M. FRAPART, O. CLEMENT, L. BINET Content  Modern imaging, especially molecular and functional imaging using chemical contrast agents, and development from small animal imaging. Courses take place at  Paris Descartes University

9. Unit 3.5 Chemistry for Imaging Program  Molecular probes and contrast agents for imaging: Synthesis, functionalisation, vectorisation, metabolism … Kinetics and pharmaco kinetics Agreement aspect, scaling up, … Application in different modalities.  State of the art of small animal imaging modalities and their applications: MRI,CEST, DNP Computed Tomography, Ultra-sounds, Nuclear imaging, EPR imaging, Visit of the different platforms.

10. Unit 3.5 Chemistry for Imaging Exam  Quizz (2 hrs) (2/3 of evaluation)  Plate-form visits with short report (1/3 of evaluation) Technical principle, applications, limitations, on one modality (10-20 p) per student. Visits can be organized in groups of three students.

11. Unit 3.6 Physics and Technology of Medical Imaging Person(s) in charge  I. Peretti, C. De Bazelaire, E. Bossy Content  Physics and technology of ultrasonic imaging, magnetic resonance imaging, nuclear medicine, X-ray imaging Courses take place at  Paris Descartes University

12. Program  imaging with non-ionizing radiation: ultrasonic imaging : ultrasound physics, image reconstruction, transducer technology magnetic resonance imaging : physical bases of NMR, conventional imaging sequences, chemical shift, high speed imaging, functional imaging  imaging with ionizing radiation: radiation physics, different types of X-ray detectors, X-ray computerized tomography nuclear tomographic imaging single photon emission computed tomography positron emission tomography Unit 3.6 Physics and Technology of Medical Imaging

13. Exam 1.written* exam (60% of evaluation) 2.project (40% of evaluation) * (oral or written at the second session) Unit 3.6 Physics and Technology of Medical Imaging

14. Unit 3.3 Medical Image Analysis Person(s) in charge  E. Decenciere, F. Cloppet Content  Main objective : to provide the students with the means to understand and use the most common tools in bio-medical image analysis  Theoretical courses and practical training sessions  Project with PhD students in biomedical image processing Courses take place at Telecom ParisTech

15. Unit 3.3 Medical Image Analysis Main topics Main topics  Foundations of image processing  Linear image processing  Morphological image processing  Segmentation  Quantification and shape characterization  Beyond the second dimension : 3D image and temporal sequences Exam Exam  Written test (40% of evaluation)  Project (30%)  Practical sessions (30%)

16. Unit 3.9a Molecular Imaging Person(s) in charge  C.A. Cuenod, D. Leguludec Content  Description of the growing field of molecular imaging.  Description of specific targets for molecular imaging and the way visualize them.  The targets will be illustrated in the context of a specific medical field and when applicable to therapeutic implications.

17. Program  Definition of molecular imaging.  Membrane, cellular metabolism and intercellular interactions,  Value of molecular imaging in biology and medicine,  In vivo maging modalities and multimodal imaging  Receptor imaging : (Applications in neurology)  Anti-bodies and membrane motifs: (Applications in oncology)  Cellular metabolism, trans-membrane transport and viability : (Applications in cardiology)  Non-membranous motifs and enzyme targets: (Applications in liver fibrosis and arterial thrombosis)  Cell Migration and tissue (re)generation, Cell therapy,  Imaging of macrophagic cells  Drugs tagging, evaluation of therapeutic effects Unit 3.9a Molecular Imaging

18. Courses take place at  Paris Descartes University Exam  Writing answers to 3 to 4 questions regarding the course content. Unit 3.9a Molecular Imaging

19. Unit 3.10a Functional & Metabolism Imaging  N. Boddaert, B. Van Beers  Brain imaging, N Boddaert 8h30-10h30. C Poupon (Neurospin) Diffusion-weighted magnetic resonance imaging. The diffusion process in biological tissues. Diffusion sensitization of MRI data. Local modeling of the diffusion process: case of the Diffusion Tensor, model and tractography, anatomical connectivity and applications. 10h30-11h30. P Ciuciu (Neurospin) Functional imaging 12h00-13h00. JC Baron (Cambridge) TEP and MRI: from theory to clinical applications. LUNCH BREAK OFFERED AT SAINTE-ANNE Hospital 14h30-15h30 N Boddaert/ M Zilbovicius (Necker). Clinical application. Anatomical and functional imaging in autism 16h00-18h00. C Oppenheim/ AD Devauchelle/ C Mellerio (St Anne). Hands on. Post processing tools: fMRI, SPM, tractography, perfusion, diffusion

20. Biomedical Engineering Master – BioImaging Track 20 Course: 8h30 – 10h30 Fast and diffusion-weighted MR imaging. Ralph Sinkus (08h30 – 09h30) Fast and diffusion-weighted MR imaging. Ralph Sinkus (08h30 – 09h30)  Principles and trade-offs of fast imaging for quantitative applications.  Single and multi-exponential analysis of diffusion-weighted MR imaging. Perfusion imaging. Charles-André Cuénod (09h30 – 10h30) Perfusion imaging. Charles-André Cuénod (09h30 – 10h30)  Dynamic contrast enhanced imaging for perfusion quantification Course: 11h00 – 13h00 Elastography. Ralph Sinkus Elastography. Ralph Sinkus  Principles of static and dynamic elastography.  Ultrasound and MR elastography.  Analysis of elastography, viscosity, and multi-frequency parameters. Course: 14h15 – 16h00 Perfusion imaging and fat quantification. Bernard Van Beers Perfusion imaging and fat quantification. Bernard Van Beers  Applications of quantitative perfusion imaging in liver diseases and abdominal tumors.  Methods and applications of fat quantification. Diffusion-weighted MR imaging. Bernard Van Beers Diffusion-weighted MR imaging. Bernard Van Beers  Value and limitations of diffusion-weighted MR imaging in liver diseases and abdominal tumors: Course: 16h20 – 18h00 Elastography. Bernard Van Beers Elastography. Bernard Van Beers  Value and limitations of elastography in liver diseases and abdominal tumors: detection, characterization and assessment of response to treatment. Biomarkers: RECIST criteria and beyond. Valérie Vilgrain Biomarkers: RECIST criteria and beyond. Valérie Vilgrain  Response evaluation criteria in solid tumors (RECIST), modified RECIST and advanced biomarkers to assess the response to targeted treatments. Unit 3.10a Functional & Metabolism Imaging

21. Courses take place at  29 November 2010 at St Anne Hospital  9 December 2010 at Paris Descartes Exam  Writing exam: 2 hours.  Multiple choices questions Unit 3.10a Functional & Metabolism Imaging

22. BIM Research Labs Image Processing Labs:  Telecom ParisTech: Medical image processing group  Paris Descartes – UFR Mathematics-Computer Sciences  Mines ParisTech: Biological image processing Radiology Labs:  Hospitals Ste Anne, HEGP, Lariboisière,….  PARCC Paris Cardiovascular Center of Research Biological Imaging Labs:  Animal imaging platform: Microscopy, Spectroscopy via Electronic Paramagnetic Resonance,  Institut d’Optique Graduate School ParisTech  ENSTA ParisTech: Laser-tissue interactions  ESPCI: novel elastography ultrasound imaging Chemistry Labs:  Chimie ParisTech  University Paris Descartes

23. BIM: after the M2…. R&D engineer:  Main industrials of whole body screening: GE, Philips, Siemens  Startups in medical imaging: Supersonic, Echosens,…  Biological imaging: Biospace Lab, Leica,…  Pharmaceutical companies: Sanofi Aventis, Guerbet, …  Medical Imaging Software: Dosisoft,  Additional: Loreal,…. PhD student:  Medical image processing  Medical imaging  Biological imaging