1. The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships” Jack Ealy Workshop La Jolla, CA July 2006 Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd.edu http://chem-faculty.ucsd.edu/sailor/

2. Death on the Danube The Economist, 2/15/00

3. Environmental sampling Field Lab

4. Smart Dust Kris Pister, UCB (1996) Available: wireless radios data processing networking protocols Need: sensors power sources

5. Smart Dust Kris Pister, UCB (1996) Need: sensors power sources

6. Silicon vapor sensors

7. Making a silicon nanostructure 20  m Electrochemical machining of nanopores

8. Silicon nanostructures mimic the beetle shell Calloodes grayanus 2 mm Chitin multilayer

9. Silicon nanostructures mimic the beetle shell Silicon multilayer

10. Silicon Microsensors

12. William R. Freeman, M.D. and Lingyun Cheng, M.D. Jacobs Retina Center UCSD

13. Mother-Ships for Nanotherapies color changes when particle releases drug Porous silicon micro-particle in the eye

14. Ruoslahti, Cancer Cell, 2002 UCSD Moores Cancer Center NIH nanoTUMOR center Erkki Ruoslahti, Burnham Inst. Sangeeta Bhatia, MIT Michael Sailor, UCSD Diagnostic Therapeutic Trigger/Actuate Targeting Species Sensor Self-Destruct Diagnostic Therapeutic Activation Targeting Self-Destruct Sensor Targeted Nanomachines

16. Backup slides

17. As with any new technology, reasonable concerns about potential hazards are appropriate. Hazards of nanotechnology University of Wisconsin, Madison Asbestos Management Program Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997- January 1998) Asbestos fibers (Nikon, inc)

18. Hazards of nanotechnology Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66, 1909-1926 (2003). Derfus, A., Chan, W. & Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Lett. (2004). 5 nm CdSe (A. Paul Alivisatos, UC Berkeley)

19. Making a silicon nanostructure 20  m

20. Encoded particles self-assemble

21. Magnetic manipulation of microparticles Nature Mater. 2004, 3, 896-899.