2. Clinical ‘Recovery’ by Day 4 vs Baseline Nimodipine Ischemic Stroke Neuroprotection Study 1985 Mathew Score (100 = intact) BaselineDay 4 Time from Onset Total Cases Mathew > 95 Mathew > 95 < 6 hrs2502 < 12 hrs15002 < 18 hrs25005 < 24 hrs37308 < 48 hrs943015

3. Treatment Effect by Time of Rx Start Nimodipine Ischemic Stroke Neuroprotection Study 1985 Mathew Score (100 = intact) Covarient Adjusted Means Hours to RxMean ScoreStd ErrP vs < 18 hr < 1869.23.6 18-2449.25.40.002 24-3050.94.80.002 30-3653.14.20.004 36-4255.75.80.05 42-4857.04.50.04

4. Hrs Onset to Arrival &Neuro Exam NINDS MR/CT Study 1988 Interval#%Cum % < 1 hrs143.4 < 2 hrs61.55.6 < 3 hrs102.48.0 < 4 hrs81.99.9 < 6 hrs712.712.6 < 12 hr265.218.9 < 24 hr7417.036.8

9. tPA < 3 hrs Rxd per Month CPMC Aug-2000 to Oct-2002

10. Acute Stroke Admissions per Month CPMC Aug-2000 to Oct-2002

12. CPMC Consecutive Cases Aug-00/Oct-02 Hrs onset to arrival (green) then to tPA (red)