1. 1 Preliminary Architectural Planning Jerusalem June 2010

2. 2 Content and Abstract Main Title Page Contents and General Explanations Map of Jerusalem and Location of the Safra Campus Map of Safra Campus and Location of ELSC Aerial Snapshot of the Safra Campus and Location of ELSC General ELSC Construction Area – Alternative A Plans of Structure in Lot – Alternative A Plans of Structure in Lot – Alternative B Plans of Structure in Lot – Alternative C Axonometric Projection of the Structure Plans of Main Entrance Level Plans schem of All Floors of the Center Facades of the Center Primary Crosscut and Panoramic Entrance Façade Scheme of Center's Area Calculations Current Situation of Center's Lot Page No. Content 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Abstract MODERN NEUROSCIENCE The profound mysteries of the mind/brain continuum have captured the attention and imagination of the very best scholars and students worldwide. The questions – how the brain enables us to sense, create, move, feel, remember - have enticed physicists, chemists, mathematicians, psychologists, physicians, and philosophers alike. As we enter the 21st century, it is increasingly clear that with larger aging populations, neurological diseases must become a major focus of research, and their cure will require a significant leap in our understanding of how detailed molecular and cellular mechanisms are linked to behavior through neuronal activity. Only then we can unlock the secrets of the brain and its malfunctioning, in order to ameliorate conditions ranging from learning disabilities in children to epilepsy, from psychiatric disorders to Parkinson’s and Alzheimer’s diseases. NEUROSCIENCE AT THE HEBREW UNIVERSITY The Hebrew University of Jerusalem is consistently rated as the top Israeli university in international surveys; its alumni and faculty have been awarded seven Nobel Prizes. Neuroscience research has been one of the most successful domains of activity at the Hebrew University. HU brain scientists have achieved international recognition for their accomplishments in many areas, including cellular, molecular and circuit functions, learning and movement control, computational and theoretical neuroscience, and human perception and cognition. In 2009, following the recommendation of an international review committee that included two Nobel Laureates, and headed by Prof. Gerald D. Fischbach of Columbia University, the Hebrew University of Jerusalem decided to establish a new center for brain research with a focus on frontier areas identified by the committee as areas of opportunity for future growth. The Edmond J. Safra Philanthropic Foundation, recognizing the tremendous promise of Hebrew University in brain research, provided a lead donation to support the establishment of the Edmond and Lily Safra Center for Brain Sciences. ELSC: SHAPING THE FUTURE OF BRAIN SCIENCE The Edmond and Lily Safra Center for Brain Sciences (ELSC) will leverage the proven promise of Hebrew University neuroscience to become one of the world’s top centers for the study of the brain. ELSC is based on the world renowned Interdisciplinary Center for Neural Computation (ICNC). At ELSC, the focus is on multidisciplinary inquiry: research groups spanning molecular, cellular, circuit and behavioral levels will work in close proximity and share common goals. This mode of research is rare in other neuroscience institutes, yet it is crucial to advancing our understanding of the brain. ELSC will enable interdisciplinary scientific teams to decipher the secrets of the brain, starting with fundamental discoveries and often leading to practical applications. Physicists, psychologists, engineers, computer scientists, and philosophers will work side by side with neurobiologists and physicians to facilitate scientific breakthroughs and to cultivate the next generation of brain scientists in an integrated interdisciplinary environment. With outstanding young faculty recruits, world-renowned experts, talented students, ample research funding, state-of-the-art equipment, and a new modern facility, the Center will serve as a powerful intellectual home for cutting-edge research and brain-related technologies. Research at ELSC will make a significant contribution to worldwide progress in brain science, and will have profound implications for the human ability to understand and treat many neurological and psychiatric disorders.

3. 3 Edmond Safra Campus In Jerusalem Mt. Scopus Campus Edmond J. Safra Campus Old City Ein Karem Campus Central train and bus Station 0 מ'1000 E.L.S.C. Site 3

4. 4 “E.L.S.C.” within Edmond J. Safra Campus Swig Dormitories Hightech Village South African Friends Synagogue Library Magnes blvd North - Pedestrian Entrance 0100 מ'200 Silberman E.L.S.C. Site Cosell Sport Center Pine Grove 4 South Entrance

5. 5 Aerial View Edmond J. Safra Campus E.L.S.C Swig Dormitories Hightech Village South African Friends Synagogue Library Magnes blvd North - Pedestrian Entrance Cosell Sport Center Silberman Pine Grove Wolfssohn 5 South Entrance

6. 6 General plan Scale: 1:1250 Philadelphia Silberman Wolfssohn Hebrew Language Academy A.Leon, P.Leon South African Friends Dworsky Bldg Maison de France Marks Purchasing Department Restaurant Synagogue E.L.S.C. Pine Grove Continuation of Magnus Avenue Silberman 6 South Entrance

7. 7 Alternative “A” plan Scale: 1:750 SilbermanWolfssohn A.Leon, P.Leon South African Friends Synagogue E.L.S.C. Continuation of Magnus Avenue Pine Grove 7 South Entrance

8. 8 SilbermanWolfssohn A.Leon, P.Leon South African Friends Synagogue E.L.S.C. Continuation of Magnus Avenue Pine Grove Alternative “B” plan Scale: 1:750 8 South Entrance

9. 9 SilbermanWolfssohn A.Leon, P.Leon South African Friends Synagogue Continuation of Magnus Avenue Pine Grove Alternative “C” plan Scale: 1:750 E.L.S.C. 9 South Entrance

10. 10 Axonometric view

11. 11 Ground Floor plan Scale: 1:250 Research Labs Seminar room Public Meeting Area Administrative Areas Toilettes Main Entrance Hall Entranceway to E.L.S.C. Seminar room Gathering area Elevators and stairways Patio Elevators And stairways Toilettes Elevators and stairways Gathering area Administrative Areas Research Labs Research labs assisting areas passageways Passageways Main Entrance Hall Research labs and assisting areas Elevators and stairways Administrative Areas Patio Public bathroom facilities Seminar rooms 11

12. 12 Floor Plans Scheme Scale: 1:750 12

13. 13 Elevations Scale: 1:500 North Elevation South Elevation West Elevation East Elevation - Entrance

14. 14 Cross Section Scale: 1:250 Cross Section Scale: 1:250 Panoramic East Elevation Scale: 1:750 Silberman Researching Labs E.L.S.C. South African Friends Researching Labs Optional Underground Parking Solar Panel System Administration Administration+ Service areas Optional Underground Parking Magnes Blvd. Patio Wolfssohn Panoramic Cfeteria

15. 15 Area Scale: 1:1000

16. 16 E.L.S.C site South African Friends Pine Grove Silberman Synagogue Aerial View E.L.S.C site Wolfssohn 16