1. Histology Laboratories Molecules to Systems 2003 Compiled by James D. Jamieson, MD/PhD Thomas L. Lentz, MD No part of this image collection may be distributed outside of the Yale University Intranet.

2. Alberts, B. et al. Molecular Biology of the Cell. 4th Edition, Garland Science, New York, 2002. Gartner, L. P. and Hiatt, J. L. Color Atlas of Histology, Williams & Wilkins, Baltimore, 1994. Kerr, J. B. Atlas of Functional Histology. Mosby, London, 1999. Kessel, R. G. and Kardon, R. H. Tissues and Organs: a text-atlas of scanning electron microscopy. W. H. Freeman, San Francisco, 1979. Lentz, T. L. Cell Fine Structure. W. B. Saunders, Philadelphia, 1971. Lodish, H. et al. Molecular Cell Biology. W. H. Freeman, New York, 2000. Mizoguti, H. Color Slide Atlas of Histology. Nihon Shashin Shinbunsha, Tokyo. Young, B. and Heath, J. W. Wheater’s Functional Histology. Churchill Livingstone, Edinburgh, 2000. Micrographs taken by George Palade, Marilyn Farquhar, James D. Jamieson, Nicolai Simionescu, Maya Simionescu, David Castle, Thomas L. Lentz. Web Resources http://info.med.yale.edu/webpath/webpath.htm Cushing Library Educational Software/Cell Biology/Several Histology Resources Acknowledgements Sources of Micrographs, Diagrams and Figures

3. Connective Tissue and Cartilage Laboratory

4. Lineage of CT cells from stem cells Note: all CT cells can make all CT molecules

6. Loose (areolar) CT Collagen type I

7. Collagen fibrils Blood vessel Smooth muscle Fibroblasts

8. Collagen fibers Plasma cells Lymphocytes

9. Areolar (Loose) Connective Tissue

10. Dense CT Collagen type I

11. Dermis of Skin

12. Achilles Tendon Fibroblasts

13. Fibroblast EM: constitutive secretion

14. Collagen Fibers Fibroblasts

15. Collagen Fibrils - periodicity

17. Reticular Fibers Collagen type III

18. Lymph Node with Reticular Fibers

19. Elastic Fibers

20. Whole Mount of Mesentery: Elastic Fibers

21. Small Artery Elastic lamina

22. Aorta: elastic fibers

23. Ligament Dense elastic fibers Vertebra

24. Elastic fibers Collagen fibrils

25. Cartilage

26. Hyaline Cartilage: Type II Collagen Matrix Chondrocytes

27. Hyaline Cartilage

28. Elastic Cartilage: Elastic Fibers Type II Collagen (pinna of ear)

29. Fibrocartilage Type I collagen

30. Adipose Tissue

31. White Fat

32. Brown Fat

33. Brown Adipose Tissue Lipid droplet Mitochondria

34. Basement Membranes

35. Basement Membrane: Silver Stain (kidney tubules)

36. Basement Membrane: Kidney Tubules (PAS stain for glycoproteins)

37. Epithelial cell Basement membrane Fibroblast

38. Cells of the Immune/Inflammatory System in the Extracellular Matrix

39. Intestinal Villus; XS Plasma Cells PMN

40. Plasma Cell

41. Loose Connective Tissue: Tongue with Mast Cells

42. Mesentery with Mast Cells

43. Mast Cell EM: Resting

44. Mast Cell: Itching

45. Macrophage

46. Some pathology to think about.

47. Chondrosarcoma

49. Ehlers-Danlos Syndrome What connective tissue molecular defects might result in this picture?

50. Ehlers-Danlos Syndrome What connective tissue molecular defects might result in this picture?

51. Lipoma in Small Intestine Submucosa

52. Submucosal Lipoma