1. Integument System Dr. Anderson GCIT

2. The Skin Largest organ in the body Functions are multipurpose – Defense against pathogens – Prevents dehydration – Retains heat

3. Skin Layers Epidermis – composed of epithelial cells (stratified) Dermis – tough, fibrous, made primarily of connective tissue (perfused by blood vessels) Hypodermis (superficial fascia) – lies just deep the dermis, and superficial to the muscular fascia, storage area for adipose tissue and anchors skin to muscles

4. Levels of Skin Tissue Organization

5. Epidermis Made up of four different cell types – Keratinocytes – Melanocytes – Dendritic Cells – Tactile (Merkel) Cells

6. Keratinocytes Arise deep to the epidermis and move outward Filled with keratin – a resilient protein that protects against abrasion and dehydration – Made within the cells themselves Tightly connected by desmosomes – why here?

7. Melanocytes Found in the deepest layer of epidermis Synthesize melanin – the pigment that gives skin its color Melanin is taken up by keratinocytes – Melanin absorbs UV light and prevents it from penetrating the nucleus

8. Melanin at Work

9. Epidermal Dendritic Cells (Langerhans Cells) Arise from bone marrow and migrate to the epidermis These cells “reach” between keratinocytes with cytoplasmic extensions, ready to intercept pathogens

10. Layers of the Epidermis Thick Skin – soles of the feet, palms, fingertips – Stratum Basale – Stratum Spinosum – Stratum Granulosum – Stratum Lucidum – Stratum Corneum Thin Skin – – All of the above strata are thinner and stratum lucidum is absent

11. Stratum Basale (Basal Layer) The deepest epidermal layer (keratinocytes and melanocytes) Comprised of stem cells (youngest keratinocytes) – Every time these cells divide, the daughter cell is pushed outward to add to the layers of cells above

12. Stratum Spinosum (Prickly Layer) Several cell layers thick Cells are connected tightly by desmosomes and collagen filaments

13. Stratum Granulosum (Granular Layer) Three to five layers of cells – Keratinocytes become filled with keratin and start to lose their organelles – Glycolipids are released by cells which help the epidermis retain water (hydrophobic interactions) – Cells start to get too far from underlying blood vessels for diffusion and begin to die

14. Stratum Corneum (Horny Layer) 20-30 cell layer thick Cells are completely keratinized, making them very resistant to abrasion, cells are constanly shed Glycolipids make the skin waterproof

15. Dermis Connective Tissue (not epithelial) Cells occurring in the dermal matrix are – Mast cells – Fibroblasts – WBC’s Richly supplied with nerve, blood and lymphatic vessels

16. Dermal Layers Papillary Layer – Areolar connective tissue – Fairly loose tissue, with spaces between cells that allow WBCs to patrol for bacteria Dermal Papillae – Outfoldings of dermis that house nerves (pain, pressure receptors) – Ultimately yields friction ridges that (on fingers and toes) make up fingerprints (or toeprints)

17. Reticular Layer Made of sparse adipose cells and thick bundles of collagen fibers These fibers run in specific directions throughout the body, leading to cleavage lines – Important to surgeons (and their patients)

18. Dermis - Functions The density of collagen fibers prevents extensive damage to this layer of tissue Collagen also binds water, keeping the skin hydrated

19. Flexure Lines Joints cause deep folds to form in skin These flexure lines have been very important in medicine in cultures around the world

20. Appendages of the Skin Derivatives of the epidermal layer (epithelial bud) Examples – Nails – Sweat glands – Oil (sebaceous) glands – Hair follicles and hair

21. Sweat Glands Up to 3 million per person! Almost evenly distributed across the entire body surface The secretory cells that make sweat are also associated with myoepithelial cells which contract when stimulated by nerves

22. Sweat Gland Types Eccrine Glands – Empty onto skin Composed of – 99% water – NaCl (salt) – Vitamin C Why are all of the solutes dissolved in sweat?

23. Sweat Gland Types Apocrine – In axillary and perineal areas (armpits and genital region) – Contents empty into the bases of hairs – Sweat from these glands also contains fats and proteins, and can feed bacteria which leads to body odor

24. Sebaceous (Oil) Glands Simple branched alveolar glands Larger glands on the face, neck and upper chest Relatively inactive in childhood, but greatly influenced by the release of androgens (during puberty)

25. Hair Composed of dead, keratinized cells filled with hard keratin Shaft – keratinized, most of hair length Root – lies within the follicle and is still being keratinized

26. Hair Follicles Hair bulb – contains nerves that sense hair position Hair papilla – contains capillaries and provides nutrients for hair growth Hair Matrix – Actively dividing area that produces the hair bulb

27. Hair Types Color varies – Usually with skin color Texture varies – Nationality – Age – Body area

28. Parasite Influence? Head Louse Body Louse Pubic Louse

29. Types of Hair and Hair Growth Vellus Hair – fine hair (children, adult females) Terminal Hair – much coarser (eyebrows, body and pubic hair at puberty)

30. Nails Specialized region of the epidermis on the distal part of a finger or toe Nail grows distally from the eponychium (cuticle) Why do we have nails?

31. Skin Disorders Cancer – Carcinoma Basal – (stratum basale) Squamous (keratinocytes – stratum spinosum) – Melanoma – cancer of melanocytes What causes cancer of the skin? How does cancer happen? Melanoma Mole