1. Feline post-traumatic ocular sarcoma Anya C. Hawthorn, MS, DVM* D. Phillip Sponenberg, DVM, PhD

2. Acknowledgements Histology: – Luther Vest – Barbara Wheeler – Jill Songer Sub-gross photography – Jerry Baber

3. Signalment and History 17 year old FS DSH Respiratory distress Mucopurulent nasal discharge Missing upper canine “Lost” right eye 8 years ago Unresponsive to antibiotics

4. Gross Findings

12. PAS

13. Feline post-traumatic ocular sarcoma associated with a past history of traumatic lens rupture believed to arise from lens epithelium or ciliary body develop 1 to 10 years after the initial injury locally invasive, may metastasize, and carry a poor prognosis Vimentin positive, cytokeratin negative, and frequently produces PAS positive material similar to lens capsule

14. References 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline Intraocular Tumors May Arise from Transformation of Lens Epithelium. Veterinary Pathology. 40:355-362. 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4 th Ed. Iowa State Press, Ames, Iowa. 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006. Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling. Veterinary Ophthalmology. 9, 6:395-403. 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats. Experimental and Toxicologic Pathology. 55: 167-172.

15. Questions Relation to feline post-vaccine sarcomas? What about the feline chronic inflammatory response is oncogenic?