Presentation is loading. Please wait.

Presentation is loading. Please wait.

1 Kumar et al, Chest 2009; 136:1237–1248. 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest.

Published byMaud Greene Modified over 9 years ago

Similar presentations

Presentation on theme: "1 Kumar et al, Chest 2009; 136:1237–1248. 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest."— Presentation transcript:

1 1 Kumar et al, Chest 2009; 136:1237–1248

2 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest 2009; 136:1237–1248

3 3 survival (%) 0204060 yeast anaerobes g-b g+c inappropriate appropriate 443 156 2002 1355 n p value odds ratio 110100 <.0001.0048 <.0001

4 4 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest 2009; 136:1237–1248

5 5 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest 2009; 136:1237–1248 Odds Ratio 1101001000 236 205 499 344 1041 1381 1912 2144 2044 2013 1659 4056 5715 <.0001 np value

6 6 Kumar et al, Chest 2009; 136:1237–1248

7 7 survival (%) 020406080 pbi cri uti sst IAI pneu inappropriate appropriate 236 205 499 344 1381 1041 n <.0001 p value odds ratio 110100

8 8 Kumar et al, Chest 2009; 136:1237–1248

9 9

10 10 Kumar et al, Chest 2009; 136:1237–1248

11 11 Kumar et al, Chest 2009; 136:1237–1248

Download ppt "1 Kumar et al, Chest 2009; 136:1237–1248. 2 Impact of Appropriateness of Initial Antimicrobial Therapy on Survival from Septic Shock Kumar et al, Chest."

Similar presentations

A Comparison of Early Versus Late Initiation of Renal Replacement Therapy in Critically III Patients with Acute Kidney Injury: A Systematic Review and.

A Comparison of Early Versus Late Initiation of Renal Replacement Therapy in Critically III Patients with Acute Kidney Injury: A Systematic Review and.
The Duration of Hypotension Prior to Initiation of Effective Antimicrobial Therapy is the Critical Determinant of Survival in Human Septic Shock Anand.

The Duration of Hypotension Prior to Initiation of Effective Antimicrobial Therapy is the Critical Determinant of Survival in Human Septic Shock Anand.
Copyright Wigfull 2013 The Sepsis Timebomb James Wigfull Critical Care and Anaesthesia Sheffield Teaching Hospitals.

Copyright Wigfull 2013 The Sepsis Timebomb James Wigfull Critical Care and Anaesthesia Sheffield Teaching Hospitals.
Serum Lactate Post-Antibiotic antibiotic † † ＊ ＊ Kumar et al. J Infect Dis 2006; 193: 251-258.

Serum Lactate Post-Antibiotic antibiotic † † ＊ ＊ Kumar et al. J Infect Dis 2006; 193:
1 Severity of illness (APACHE II score ≥ 25) stratified by RIFLE category in septic shock 28.3 45.2 58.6 69.9 0 10 20 30 40 50 60 70 80 NoneRiskInjuryFailure.

1 Severity of illness (APACHE II score ≥ 25) stratified by RIFLE category in septic shock NoneRiskInjuryFailure.
1 Heparin-associated 30 Day Mortality Zarychanski et al, CCM 2008;36:2973-9.

1 Heparin-associated 30 Day Mortality Zarychanski et al, CCM 2008;36:
1 MT vs CT: 28 day survival 10779969378958811223 10469398678268011223 Number at risk CT MT 868 779 0 25 50 75 100 051015202528 day % Surviving Monotherapy.

1 MT vs CT: 28 day survival Number at risk CT MT day % Surviving Monotherapy.
1 Kumar et al. CCM. 2006:34:1589-96. Cumulative Initiation of Effective Antimicrobial Therapy and Survival in Septic Shock time from hypotension onset.

1 Kumar et al. CCM. 2006:34: Cumulative Initiation of Effective Antimicrobial Therapy and Survival in Septic Shock time from hypotension onset.
(a) (b) (c) (d). What is (1,2,3)  (3,4,2)? (a) (1, 2, 3, 4) (b) (1,2)  (3,4) (c) (1,3,4,2) (d) (3,1)  (4,2)

(a) (b) (c) (d). What is (1,2,3)  (3,4,2)? (a) (1, 2, 3, 4) (b) (1,2)  (3,4) (c) (1,3,4,2) (d) (3,1)  (4,2)
SEPSIS Early recognition and management. Aims of the talk Understand the definition of sepsis and severe sepsis Understand the clinical significance of.

SEPSIS Early recognition and management. Aims of the talk Understand the definition of sepsis and severe sepsis Understand the clinical significance of.
Estimates of the Impact of Sepsis Syndromes Annually in U.S. Sepsis 200,000 Severe sepsis 200,000 Septic shock 200,000 Mortality Deaths -46%92,000 -20%40,000.

Estimates of the Impact of Sepsis Syndromes Annually in U.S. Sepsis 200,000 Severe sepsis 200,000 Septic shock 200,000 Mortality Deaths -46%92, %40,000.
Solomon Tesfaye et al N Engl J Med 2005;352:341- 50 Comparison of Baseline Data in 1819 Patients According to Whether There Was an Assessment for Neuropathy.

Solomon Tesfaye et al N Engl J Med 2005;352: Comparison of Baseline Data in 1819 Patients According to Whether There Was an Assessment for Neuropathy.
Literature Appraisal Effectiveness of Therapy. Measures of treatment effect Statistical significance Odds ratio Relative risk Absolute risk reduction.

Literature Appraisal Effectiveness of Therapy. Measures of treatment effect Statistical significance Odds ratio Relative risk Absolute risk reduction.
Date of download: 5/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Recent Advances in Cardiopulmonary Resuscitation:

Date of download: 5/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Recent Advances in Cardiopulmonary Resuscitation:
Dr Alex Hieatt, EM Consultant MEHT Dr Ron Daniels, Chair of the UK Sepsis Trust and Global Sepsis Alliance (Slides with permission.)

Dr Alex Hieatt, EM Consultant MEHT Dr Ron Daniels, Chair of the UK Sepsis Trust and Global Sepsis Alliance (Slides with permission.)
SIRS S EPSIS S EVERE S EPSIS S EPTIC S HOCK D EATH Early recognition Early antibiotics Source control.

SIRS S EPSIS S EVERE S EPSIS S EPTIC S HOCK D EATH Early recognition Early antibiotics Source control.
1) Initiation of ICS therapy or 2) Increase ICS therapy (50% dose increase) Baseline period: 1 year Outcome period: 2 years Extra-fine HFA-BDP via MDI.

1) Initiation of ICS therapy or 2) Increase ICS therapy (50% dose increase) Baseline period: 1 year Outcome period: 2 years Extra-fine HFA-BDP via MDI.
Preventing Sepsis in Wales

Preventing Sepsis in Wales
10/3/2014. Εμφραγμα - Στηθαγχη - Πονος στο στηθος : Εμφραγμα μυοκαρδιου λεμε την βαρυτατη εκεινη κατασταση που οφειλεται στην αποφραξη που μπορει να γινει.

10/3/2014. Εμφραγμα - Στηθαγχη - Πονος στο στηθος : Εμφραγμα μυοκαρδιου λεμε την βαρυτατη εκεινη κατασταση που οφειλεται στην αποφραξη που μπορει να γινει.
Sepsis is a common and potentially life-threatening condition: the body’s immune system goes into overdrive in response to an infection, that can lead.

Sepsis is a common and potentially life-threatening condition: the body’s immune system goes into overdrive in response to an infection, that can lead.

Similar presentations

Ads by Google