1. © 2004 Current Medicine Group Ltd FISIOLOGÍA DIGESTIVA (BCM II) Clase 7: Gastritis y H. pylori Dr. Michel Baró A.

2. © 2004 Current Medicine Group Ltd Gastritis: overview of anatomy and histology

3. © 2004 Current Medicine Group Ltd Normal fundic mucosa

4. © 2004 Current Medicine Group Ltd General classification of gastritis

5. © 2004 Current Medicine Group Ltd Endoscopic erosive gastritis

6. © 2004 Current Medicine Group Ltd Erosive gastritis

7. © 2004 Current Medicine Group Ltd Gastritis: anti inflamatorios no esteroidales y aspirina (“Gastropatía”)

8. © 2004 Current Medicine Group Ltd Acute erosive hemorrhagic gastritis

9. © 2004 Current Medicine Group Ltd Endoscopic gastritis: alcohol Gastropatía hemorrágica alcohólica

10. © 2004 Current Medicine Group Ltd Alcoholic hemorrhagic gastritis: histologic features Epitelio intacto Bandas Hemorrágicas interglandulares Edema Ausencia de Infiltrado inflmatorio

11. © 2004 Current Medicine Group Ltd Chronic gastritis: nonspecific gastritis (a) TABLE 5 - 10A. CHRONIC GASTRITIS: NONSPECIFIC GASTRITIS - HELICOBACTER PYLORI

12. © 2004 Current Medicine Group Ltd Chronic gastritis: nonspecific gastritis (b)

13. © 2004 Current Medicine Group Ltd Nonerosive nonspecific gastritis: activity (a) Gastritis crónica superficial, activa (infiltrado neutrófilos y mononucleares)

14. © 2004 Current Medicine Group Ltd Nonerosive nonspecific gastritis: activity (b) Gastritis crónica superficial (infiltrado sólo mononucleares)

15. © 2004 Current Medicine Group Ltd Foveolar hyperplasia

16. © 2004 Current Medicine Group Ltd Intestinal metaplasia

17. © 2004 Current Medicine Group Ltd Endocrine consequences of chronic atrophic gastritis

18. © 2004 Current Medicine Group Ltd Enterochromaffin-like cell hyperplasia

19. © 2004 Current Medicine Group Ltd Distributions of nonerosive, nonspecific gastritis Se asocia a la presencia de H. pylori Úlcera duodenal 90% Úlcera gástrica 50-80% Anemia perniciosa Gastritis auto-inmune

20. © 2004 Current Medicine Group Ltd Serum pepsinogens and chronic gastritis

21. © 2004 Current Medicine Group Ltd Chronic gastritis: specific or distinctive gastritis

22. © 2004 Current Medicine Group Ltd Morphology and taxonomy

23. © 2004 Current Medicine Group Ltd Electron micrographs from Helicobacter pylori-infected patient (A)

24. © 2004 Current Medicine Group Ltd Electron micrographs from Helicobacter pylori-infected patient (B)

25. © 2004 Current Medicine Group Ltd Prevalence by age and country of origin (A)

26. © 2004 Current Medicine Group Ltd Prevalence by age and country of origin (B)

27. © 2004 Current Medicine Group Ltd Prevalence by ethnic group

28. © 2004 Current Medicine Group Ltd Clustering of organism within families

29. © 2004 Current Medicine Group Ltd Histologic stains (A) Warthin.Starry

30. © 2004 Current Medicine Group Ltd Histologic stains (B) Giemsa

31. © 2004 Current Medicine Group Ltd Histologic stains (C) Acridina

32. © 2004 Current Medicine Group Ltd Histologic stains (D) Gimenez

33. © 2004 Current Medicine Group Ltd Histologic stains (E) Hematoxilina-eosina

34. © 2004 Current Medicine Group Ltd Urease

35. © 2004 Current Medicine Group Ltd Urea breath tests (C13 and C14)

36. © 2004 Current Medicine Group Ltd Rapid urease tests

37. © 2004 Current Medicine Group Ltd Tests for diagnosis of Helicobacter pylori can be categorized

38. © 2004 Current Medicine Group Ltd Association of Helicobacter pylori with gastrointestinal disease

39. © 2004 Current Medicine Group Ltd Helicobacter pylori and chronic active gastritis

40. © 2004 Current Medicine Group Ltd Antral (type B) gastritis 95% porta H. pylori

41. © 2004 Current Medicine Group Ltd Helicobacter pylori's initiation of mucosal inflammation

42. © 2004 Current Medicine Group Ltd Pathway of Helicobacter pylori induction

43. © 2004 Current Medicine Group Ltd Lymphoid follicle

44. © 2004 Current Medicine Group Ltd Gastric metaplasia

45. © 2004 Current Medicine Group Ltd Histology of gastric metaplasia (A) (duodeno)

46. © 2004 Current Medicine Group Ltd Histology of gastric metaplasia (B)

47. © 2004 Current Medicine Group Ltd Helicobacter pylori and peptic ulcer disease

48. © 2004 Current Medicine Group Ltd Helicobacter pylori and peptic ulcer disease

49. © 2004 Current Medicine Group Ltd Helicobacter pylori and serum gastrin concentrations

50. © 2004 Current Medicine Group Ltd Effect of Helicobacter Pylori eradication

51. © 2004 Current Medicine Group Ltd H. Pylori y carcinoma: Epidemiology and geographic data

52. © 2004 Current Medicine Group Ltd Stored sera were analyzed for Helicobacter pylori

53. © 2004 Current Medicine Group Ltd Characteristics of gross pathology

54. © 2004 Current Medicine Group Ltd Relationship of Helicobacter pylori to gastric cancer

55. © 2004 Current Medicine Group Ltd Non-Hodgkin's lymphoma of the stomach

56. © 2004 Current Medicine Group Ltd Dense lymphoid infiltrate Hiperplasia Folicular

57. © 2004 Current Medicine Group Ltd Lymphoepithelial lesion Linfoma MALT (linfocitos B)

58. © 2004 Current Medicine Group Ltd Cytokeratin stains (A) Normal

59. © 2004 Current Medicine Group Ltd Cytokeratin stains (B) MALT lymphoma Linfoma MALT (linfocitos B)

60. © 2004 Current Medicine Group Ltd Regression of gastric mucosa-associated lymphoid tissue

61. © 2004 Current Medicine Group Ltd FIN