1. A Goat on Bald Mountain Case 05-1829 Thomas E. Cecere North Carolina State University Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

2. Signalment/History Castrated male adult mixed-breed goat Complete shed in spring for past several years – hair regrows over the summer Most recent episode – no hair regrowth Progressive ptyalism starting in spring Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

10. Morphologic Diagnosis Salivary gland: Diffuse, severe lymphocytic and eosinophilic sialoadenitis with atrophy and interstitial fibrosis Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

12. Thymoma associated diseases Dry mouth (Sjogren Syndrome), alopecia areata, myesthenia gravis and others in humans Sjogren Syndrome Keratoconjunctivitis sicca, xerostomia Immune-mediated destruction of lacrimal and salivary gland Primary vs. secondary (rheumatoid arthritis, SLE, polymyositis, scleroderma, thymoma) Xerostomia vs. Ptyalism in this case? Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

13. Alopecia Areata Autoimmune skin disease Non-scarring alopecia Lymphocytic targeting of anagen hair bulbs Associated with thymoma in humans Alopecia Universalis Thymoma associated exfoliative dermatitis Cats, rabbits Lymphocytic mural folliculitis Rottenberg S et al. Thymoma- associated exfoliative dermatitis in cats. Vet Pathol. 2004 Jul;41(4):429-33. Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

14. Acknowledgements Keith Linder Kristi Mozzachio NCSU Histology Lab – Sandra Horton Arnaud, Arun, Danielle, Crystal, Midori, Sally Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

15. Questions? Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only