1. Research Opportunities Claude Ervin Davis III, Ph.D. East Carolina University November 14, 2005

2. Outline Health Psychology, Behavioral Medicine, & Cognitive Neuroscience Some Research History –Chronic Pain –Emotion with fMRI –Pain & Emotion with fMRI –Mental Illness & Cognitive Impairment Psychophysiology and EEG Lab

3. Some Research History Psychological Factors in Headache and Orofacial Pain Structural Equation Model to Predict Orofacial Pain Brain Mechanisms of Emotion Processing with fMRI Brain Mechanisms of Pain Processing with fMRI

4. Anger and Fear Affect Pain Related Brain Activity Patients with Chronic Pain Affected by Stress & Emotion Model for Face Pain Brief Painful Heat Stimulation Functional Magnetic Resonance Imaging fMRI – Blood Oxygen Level – Brain Activity

5. Brain Mechanisms of Pain Model Brief Repeated Trials of Painful Heat Stimulation Pain alone Pain with Anger Recall Pain with Fear Recall Observe the effect of anger and fear on pain Start with healthy, pain-free individuals

6. fMRI Scanning

7. Thermal Stimulation-Apparatus Photos courtesy of Reny de Leeuw, D.D.S, Ph.D.

8. Thermal Stimulation 48 o C 39 o C

9. Producing Fear and Anger Personal Episodic Emotional Recall A time you felt very Angry, Fearful, or Neutral Neutral Desk Sitting Bedroom Lamp Anger Brother Yelling Telephone Money Fear Julie Explorer Crash Blood

10. Brain Mechanisms of Emotion Personal Episodic Emotional Recall AngerFear LRLR 1.0 0.0 p<.05 Davis, C. E., Blonder, L. X., Andersen, A. H. & Carlson, C. R. (Under Review). (eta 2 )

11. Brain Mechanisms of Pain Painful Stimulation and Anger Recall PainPain and Anger Note: Pain is (Pain – Warm Sensation) p<.05 1.0 LR Davis, C. E., Blonder, L. X., Andersen, A. H. & Carlson, C. R. (Under Review). LR 0.0 1.0 (eta 2 )

12. Brain Mechanisms of Pain Painful Stimulation and Fear Recall Pain LR Pain and Fear p<.05 LR 1.0 0.0 Note: Pain is (Pain – Warm Sensation) Davis, C. E., Blonder, L. X., Andersen, A. H. & Carlson, C. R. (Under Review). (eta 2 )

13. Mental Illness & Cognitive Impairment Real World Decision-Making, Complex Decision-Making/ Conjoint Analysis

14. Psychophysiology & EEG Lab Psychophysiology System –Heart Rate / Electrocardiogram (ECG) –Muscle Tension / Electromyogram (EMG) –Respiration –Finger Temperature –Skin Conductance (SCR) –Brain Activity /Electroencephalogram (EEG) (2 CH) EEG System (32 CH)

15. Psychophysiology System I-330-C2+ 12 Channel

16. EEG System

17. Questions? ? ? ? ? ? ?