1. An Overview of Psychiatric Medications for Children and Adolesscents John Webber, M.D. Youth Home, Inc. (501) 821-5500

2. Objectives The importance of child/teen mental health. Principles of medication treatment Comprehensive but not exhaustive overview of psychiatric medications. In-depth review of antidepressants Provide time for questions and discussion.

3. Goals Add to your understanding of why medications are prescribed for children and teenagers. Adle to distinguish between antidepressants, stimulants, antipsychotics and anticonvulsants. Recognize brand and generic names in each class of psychiatric medications.

4. Housekeeping This presentation and your handout will follow the convention of listing the generic name followed by the brand name. For example, Sertraline (Zoloft) *medications are newest

5. Normal Behavior Children – Imaginary friends – Events controlled by thoughts/feelings Teens – Moody and irritable – Oppositional and antisocial – Unique insights into the nature of reality

6. Medication Priniciples The full range of psychiatric medications are prescribed for children and teenagers. Several medications are used off-label. Medication is itself a therapeutic issue

7. Psychotropic Medications Stimulants Other medications to treat ADHD Antipsychotic medications Mood Stabilizers Antidepressants

8. Stimulant Medications

9. Methylphenidate Ritalin is the best known example Includes Metadate, Methylin, Focalin Concerta is a longer-acting form of methylphenidate with a unique design Daytrana is a transdermal patch

10. Dextroamphetamine Dexedrine and Dextrostat Adderall and Adderall XR

11. Newest Class of ADHD Medications (Prodrug Stimulant) Lisdexamfetamine dimesylate (Vyvanse)

12. Other Medications to Treat Attention Deficit Hyperactivity Disorder

13. Nonstimulant Medications Atomoxetine(Strattera) Guanfacine(Tenex, *Intuniv) Bupropion(Wellbutrin) Clonidine(Catapres, *Kapvay) Imipramine(Tofranil)

14. Antipsychotic Medications

15. Antipsychotics Psychotic disorders Bipolar disorder Irritability associated with autism Severely agitated/violent behaviors

16. Antipsychotic Medications Typical or Conventional or 1 st generation Atypical or Novel or 2 nd generation

17. Typical/Conventional/1 st Generation Haloperidol(Haldol) Pimozide(Orap) Chlorpromazine(Thorazine) Thioridazine(Mellaril)

18. Atypical/Novel/2 nd Generation Clozapine(Clozaril) Risperidone(Risperdal) Olanzapine(Zyprexa) Quetiapine(Seroquel) Ziprasidone(Geodon) Aripiprazole(Abilify) *Paliperidone(Invega) *Iloperidone(Fanapt) *Asenapine(Saphris) *Lurasidone(Latuda)

19. Aripiprazole (Abilify) FDA approved for the treatment of: – Autism (Irritability)6 to 17 years old – Bipolar Disorder10 to 17 years old – Schizophrenia13 to 17 years old

20. Quetiapine (Seroquel, Seroquel XR) FDA approved for the treatment of: – Bipolar Disorder10 to 17 years old – Schizophrenia13 to 17 years old Seroquel XR not approved < 18 years old

21. Risperidone (Risperdal) FDA approved for the treatment of: – Autism (Irritability) 5 to 16 years old – Bipolar Disorder10 to 17 years old – Schizophrenia13 to 17 years old

22. Olanzapine (Zyprexa) FDA approved for the treatment of: – Bipolar Disorder13 to 17 years old – Schizophrenia13 to 17 years old

23. *Paliperidone (Invega) FDA approved for the treatment of: – Schizophrenia12 to 17 years old

24. Clozapine (Clozaril) Gold standard for treating schizophrenia Two previous therapeutic trials Clozaril National Registry Labs each week X 6 months

25. Mood Stabilizers

26. Lithium Anticonvulsants or AED

27. Lithium (Eskalith, Lithobid) Effective in treating manic symptoms Used in combination with other medications to treat resistant depression Protects against suicidal behavior “Lost” medication

28. Anticonvulsants/AED Divalproex Sodium(Depakote) Carbamazepine(Tegretol) Oxcarbazepine(Trileptal) Gabapentin(Neurontin) Topiramate(Topamax)

29. Antidepressant Medications

30. The Opposite of Depression is….

31. Classes of Antidepressant Tricyclic Antidepressants Selective Serotonin Reuptake Inhibitors Novel Antidepressant

32. Tricyclic Antidepressants Amitriptyline(Elavil) Imipramine(Tofranil) Clomipramine(Anafranil)

33. Tricyclics DepressionNot recommended OCDClomipramine ADHDImipramine School PhobiaMixed Results BedwettingAmitriptyline/Imipramine Night TerrorsImipramine

34. Selective Serotonin Reuptake Inhibitors (SSRIs) Preferred medications for treating child and adolescent depression First line treatment for GAD, OCD, PTSD, and panic disorder

35. Selective Serotonin Reuptake Inhibitors Fluoxetine(Prozac) Parosetine(Paxil) Sertraline(Zoloft) Fluvoxamine(Luvox) Citalopram(Celexa) Escitalopram(Lexapro) *Vilazodone(Vibryd)

36. Fluoxetine (Prozac) First SSRI in the United States (1987) FDA approved MDD8 to 18 years old FDA approved OCD7 to 17 years old Long-acting so useful in noncompliance

37. Sertraline (Zoloft) FDA approved OCD6 to 17 years old Scored tablets provide flexibility

38. Fluvoxamine (Luvox) FDA approved OCD8 to 17 years old Generic fluvoxamine is available

39. Escitalopram (Lexapro) FDA approved MDD12 to 17 years old Don’t need much – 10 mg. is about the same as 40 mg. Celexa

40. SSRI Summary SSRIs preferred in child/teen depression LexaproDepression ProzacDepression and OCD ZoloftOCD FluvoxamineOCD

41. Novel Antidepressants Bupropion(Wellbutrin, *Aplenzin) Mirtazapine(Remeron) Venlafaxine(Effexor) Desvenlafaxine(Pristiq) Duloxetine(Cymbalta) Trazodone(*Oleptro)

42. Buproprion (Wellbutrin, Wellbutrin SR, Wellbutrin XL, *Aplenzin Option for Depression + ADHD Should not be used with a history of eating disorder or seizures Bupropion is a treatment for smoking

43. Mirtazapine (Remeron) Complex mechanism of action involving multiple neurotransmitter systems Rapid onset of action in adults Sedating so prescribed at bedtime Good choice for “anxious” depression

44. Serotonin Norepinephrine Reuptake Inhibitors (SNRIs) Venlafaxine(Effexor) Desvenlafaxine(Pristiq) Duloxetine(Cymbalta)

45. Venlafaxine (Effexor, Effexor XR) Not recommended due to side effects (increased diastolic blood pressure, increased pulse, dermatological)

46. Duloxetine (Cymbalta) Relief of physical symptoms Do NOT use with a history of liver disease

47. Conclusions Children/teens can and do have serious mental illness including Major Depression, Bipolar Disorder, and Schizophrenia The full range of psychiatric medications are prescribed to those < 18 years of age Medication is only one part of treatment Many new medications are actually “old wine in new bottles”

48. Resources ParentsMedGuide.org American Academy of Child and Adolescent Psychiatry