1. E-mail: itlambev@mail.bg
Medical University of Sofia, Faculty of Medicine
Department of Pharmacology and Toxicology
Angio (vaso)-
protectors
(Summary)
Assoc. Prof. Iv. Lambev

2. I. Drugs improving capillary function
(capillarotonic drugs)
They reduce capillary fragility and
permeability and prevent basal edothelium
membrane damage. They act like antioxidants
and prevent vitamin C and adrenaline oxidation.
These drugs also inhibit lipid oxidation and
synthesis of active oxygen species.

3. Drugs improving capillary function
 Bioflavonoids: Diosmin
Hesperidin, Hyperoside,
Naringin, Quercetin, Rutin
Rutascorbin® (rutin/ascorbic acid)
 Semisynthetic flavonoids:
Troxerutin®
Saponins: Escin (derived from Aesculus
hippocastanum – Horse-chestnut)
Combinations: Peflavit C®
 Synthetic preparations: Calcium dobesilate
(Doxium® – in retinopathy)

4. Aesculus
hippocastanum
(Horse-chestnut)

5. Bioflavonoids Fr. Cynosbati (Dog rose) Hb. Hyperici (St. John’s wort)
Fr. Crataegi
(Hawthorn)
Fruits of citrus

6. Hb. Hyperici
(St. John’s wort)

7. Fr. Crataegi
(Hawthorn)

8. Drugs improving capillary function
are indicated in haemorrhagic diathesis,
skin and retinal haemorrhages, different
forms of capillary dysfunctions, radiation
disease, infections and allergic diseases,
varicose veins, atherosclerosis, hypertension,
rheumatism, hepatitis, glomerulonephritis,
meno- and methrorrhagias, paradontosis,
drug capillary dysfunctions
(caused by NSAIDs, glucocorticoids, reserpine,
anticoagulants, arsenic compounds, gold salts).

9. Atherosclerotic gangrene of foot

10. Warfarin necrosis of breast skin
5 days after intaking of warfarin

11. Detralex® (diosmin/hesperidine)
II. VENOTONIC DRUGS
Detralex®, Endotelon®, Phelobodia®
Troxerutin (Troxevasin®)
Detralex® (diosmin/hesperidine)
improves capillary functions, has
venotonic and antiexudative action
too, due to inhibition of PGs release.
It inhibits leukocyte adhesion
and migration. Detralex enhances
lymphatic flow and drainage.

12. Detralex®. Its venotonic effects
is due to the prolonged NA action.
Detralex improves skin perfusion and
rheological properties of the blood. It is
effective in chronic venous insufficiency,
venous ulcer, hemorrhoids.
Dosage: 2 x 1 tablet daily.

13. Endotelon® is a purified and
standardized extract of
of grape seeds, contains procyanidolic
oligomeres. It has endothelium
protective and venotonic effects.
Endotelon is prescribed p.o. in chronic
venous and lymphatic insufficiency.

14. Varicose veins
Varicose ulcer

15. Troxerutin (trihydroxyethylrutin)
has venotonic, antiexudative and haemostatic
activity. It improves capillary function and
inhibits thrombocyte aggregation too.
Troxerutin is used in varicose ulcers,
chronic venous insufficiency, superficial
thrombophlebitis, haemorrhoids, phlebo-
sclerosis, muscle cramps, pain of traumatic
origin (sprain, luxation). It is administered
orally or locally, applied on the damaged
area (2% gel).

16. III. Heparin-containing… ointments
(used in superficial thrombophlebitis
and varicose veins):
Heparoid®, Lioton® 1000 gel
IV. Antihaemorrhoidal drugs
Detralex® (orally)
Doloproct® (fluocortolone/lidocaine): supp.
and ointment
Procto-Glyvenol® (tribenoside/lidocaie): supp.
Ultraproct® (fluocortolone/cinchocaine): supp.