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This article and any supplementary material should be cited as follows: Yu H, Wergedal JE, Rundle CH, Moham S. Reduced bone mass accrual in mouse model.

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Presentation on theme: "This article and any supplementary material should be cited as follows: Yu H, Wergedal JE, Rundle CH, Moham S. Reduced bone mass accrual in mouse model."— Presentation transcript:

1 This article and any supplementary material should be cited as follows: Yu H, Wergedal JE, Rundle CH, Moham S. Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury. J Rehabil Res Dev. 2014;51(9):1427–38. http://dx.doi.org/10.1682/JRRD.2014.04.0095 Slideshow Project DOI:10.1682/JRRD.2014.04.0095JSP Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury Hongrun Yu, PhD; Jon E. Wergedal, PhD; Charles H. Rundle, PhD; Subburaman Mohan, PhD

2 This article and any supplementary material should be cited as follows: Yu H, Wergedal JE, Rundle CH, Moham S. Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury. J Rehabil Res Dev. 2014;51(9):1427–38. http://dx.doi.org/10.1682/JRRD.2014.04.0095 Slideshow Project DOI:10.1682/JRRD.2014.04.0095JSP Aim – Use female mouse model to evaluate effects of mild traumatic brain injury (TBI) on skeleton. Relevance – TBI can affect bone by influencing the production/ actions of pituitary hormones and neuropeptides important to bone metabolism regulation.

3 This article and any supplementary material should be cited as follows: Yu H, Wergedal JE, Rundle CH, Moham S. Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury. J Rehabil Res Dev. 2014;51(9):1427–38. http://dx.doi.org/10.1682/JRRD.2014.04.0095 Slideshow Project DOI:10.1682/JRRD.2014.04.0095JSP Methods Created repetitive mild TBI model. – 95 g drop weight and 1 m drop height. – 18 mice (9 experimental and 9 control). Measured in vivo bone parameters of total body and specific skeletal tissues 1 and 2 wk after 1st impact. After 2nd measurement, euthanized mice and collected trunk blood, brain, tibias, and femurs. Performed brain gene expression analysis, brain histological analysis, and bone strength test.

4 This article and any supplementary material should be cited as follows: Yu H, Wergedal JE, Rundle CH, Moham S. Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury. J Rehabil Res Dev. 2014;51(9):1427–38. http://dx.doi.org/10.1682/JRRD.2014.04.0095 Slideshow Project DOI:10.1682/JRRD.2014.04.0095JSP Results 2 wk after 1st impact, mice subjected to repetitive mild TBI showed: – Microhemorrhaging. – Astrocytosis. – Increased anti-inflammatory protective actions in brain. – Reduced (28.9%) serum insulin-like growth factor 1 levels. – Significantly reduced bone mass. – Reduced tibial total cortical (7%) and trabecular (27.5%) bone density. Led to weaker bones.

5 This article and any supplementary material should be cited as follows: Yu H, Wergedal JE, Rundle CH, Moham S. Reduced bone mass accrual in mouse model of repetitive mild traumatic brain injury. J Rehabil Res Dev. 2014;51(9):1427–38. http://dx.doi.org/10.1682/JRRD.2014.04.0095 Slideshow Project DOI:10.1682/JRRD.2014.04.0095JSP Conclusions Repetitive mild TBI exerted significant negative effects on accrual of both cortical and trabecular bone mass in mice. – Reduced bone formation rate. Reduced serum IGF-I could be one contributing factor for the negative effects of mild TBI on bone formation.

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