2. Are You Another Einstein?

3. Take 5 minutes to answer this question in your notebook…

4. Certain poisons such as DNP are classified as uncouplers. They poison the cell by making the inner mitochondrial membranes permeable to H+. Explain how this would affect cellular respiration. Infer any possible symptoms that would be caused by ingesting this poison.

5. 5 minutes Certain poisons such as DNP are classified as uncouplers. They poison the cell by making the inner mitochondrial membranes permeable to H+. Explain how this would affect cellular respiration. Infer any possible symptoms that would be caused by ingesting this poison.

6. 4 minutes Certain poisons such as DNP are classified as uncouplers. They poison the cell by making the inner mitochondrial membranes permeable to H+. Explain how this would affect cellular respiration. Infer any possible symptoms that would be caused by ingesting this poison.

7. 3 minutes Certain poisons such as DNP are classified as uncouplers. They poison the cell by making the inner mitochondrial membranes permeable to H+. Explain how this would affect cellular respiration. Infer any possible symptoms that would be caused by ingesting this poison.

8. 2 minutes Certain poisons such as DNP are classified as uncouplers. They poison the cell by making the inner mitochondrial membranes permeable to H+. Explain how this would affect cellular respiration. Infer any possible symptoms that would be caused by ingesting this poison.

9. 1 minute Certain poisons such as DNP are classified as uncouplers. They poison the cell by making the inner mitochondrial membranes permeable to H+. Explain how this would affect cellular respiration. Infer any possible symptoms that would be caused by ingesting this poison.

10. 10 seconds

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12. 8 seconds

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15. 5 seconds

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17. 3 seconds

18. 2 seconds

19. 1 second

20. It’s Time to Start Class! E =MC 2

21. Uncouplers prevent a H+ gradient from forming by allowing H+ to diffuse through the membrane (instead of ATP synthase). This prevents ATP synthase from harnessing the energy of the ETC and thus, it cannot phosphorylate ADP to make ATP. Cells continue to consume O2 and food to be broken down in Glycolysis, the TCA, and the ETC. Therefore, the other energy captured from glucose is lost as heat (instead of being used by ATP synthase). -Loss of weight -Excess sweating -Increase in body temperature -Protein denaturation = no metabolism = death