1. DiencephalonDiencephalon

2. HypothalamusHypothalamus

3. General information n Part of diencephalon n Weighs about 4 grams The whole brain weighs 1 400 grams n Occupies the bottom and infero-lateral walls of the III ventricle

4. Topography n In the center of the limbic system. n At the crossing of numerous nerve pathways. Surrounded by the circle of Willis. Surrounded by the circle of Willis.

5. Boundaries AnteriorLamina terminalis PosteriorCorpora mammillaria DorsalSulcus hypothalamicus MedialІІІ стомахче LateralSubthalamus & capsula interna VentralChiasma opticum, tuber cinereum, corpora mammillaria & neurohypophysis

6. n Chiasma opticum n Infundibulum n Tuber cinereum n Corpus mamillare n Tractus opticus Anatomy

7. Organization n Composed of lateral and medial zones divided by fornix. n Nuclei of the lateral zone concerned with feeding (center of hunger) and drinking (center of thirst). n Nuclei of the medial zone grouped in 3 regions: regio anterior, tuberalis and posterior.

9. Хипоталамични области и ядра n Латерална област n Nucl. preopticus lateralis n Nucl. hypothalamicus lateralis n Медиална област ÊRegio preoptica n Nucl. preopticus medialis n Полово диморфично ядро ËRegio supraoptica n Nucl. suprachiasmatis n Nucl. anterior n Nucl. paraventricularis n Nnucl. supraopticus ÌRegio tuberalis n Nucl. dorsomedialis n Nucl. ventromedialis n Nucl arcuatus ÍRegio mamillaris n Nucll. mamillares n Nucl. posterior

10. Crossed by fasciculus prosencephalicus medialis Contains two nuclei: 1. Nucleus preopticus lateralis 2. Nucleus hypothalamicus lateralis - when stimulated feeling of hunger - when destroyed anorexia nervosa and fast Lateral zone

11. Nucleus preopticusControl of parasympathetic function Nucleus supraopticusSynthesis and secretion of vasopressin. Damage causes diabetes insipidus. Nucleus suprachiasmaticus Fibers from the retina; fibers to the pineal body. Controls circadian rhythms. Nucleus anteriorControls temperature and sexual behavior. Nucleus paraventricularisSynthesis and secretion of oxytocin (milk secretion & uterine contraction). Controls food intake Regio anterior

12. Hypothalamus

13. Nucleus dorsomedialis - center of hunger - on stimulation rage, cruelty Nucleus ventromedialis - center of satiety - on stimulation depression of apetite Nucleus arcuatus - periventricular in tuber cinereum - secretes releasing-factors - dopaminergic neurons, inhibit release of prolactin Regio tuberalis

15. Nucleus mamillaris - impulses from hippocampal formation via fornix - impulses from tegmental nuclei, nuclei raphae via pedunculus mamillaris - projections to nucleus anterior thalami via tractus mamillothalamicus Nucleus posterior - controls thermoregulation (съхранение и образуване на топлина) - damage causes poikilothermia – inability of thermoregulation Regio posterior

17. Connections

18. Connections Extensive and complex, can be summarized in 3 categories:  Connections with the limbic system  Connections with the pituitary gland  Connections with somatic and visceral nuclei

19. 1) Fasciculus prosencephalicus medialis: visceral function 2) Tractus supraopticohypophysialis: neurosecretion 3) Tractus tuberoinfundibularis: liberins & statins 4) Afferents from corpora mamillaria: visceral function 5) Efferents to brainstem & spinal cord: autonomous function

20. Connections

21. Afferents - nucleus tractus solitarii – visceral information via vagus. - formatio reticularis –various information from spinal cord. - retina – to nucl. suprachiasmaticus. Circadian rhythm. - circumventricular organs – lacks blood-brain bareer. Control of substances isolated from the CNS, e.g., toxins. - limbic and olfactory system –controls behavior reactions. - intrinsic receptors, monitor temperature and water balance.

22. Main afferents From most parts of brain. Most pathways are non-myelinated and small. Fasciculus prosencephalicus medialis n From area septalis & area olfactoria lateralis to hypothalamic nuclei. n Integrates olfaction with emotions and feeding. Stria terminalis n From corpus amygdaloideum and area septalis to regio preoptica and nuclei hypothalamici anteriores. n Controls physiological response to emotions and sexual arousal. Fornix n From formatio hippocampalis to corpora mammillaria. n Integrates memory, emotions and visceral reactions.

24. Main efferents Fasciculus mammillothalamicus n From nuclei mamillares to nucleus anterior of thalamus. n Creating and coding memory traces. Hypothalamo-reticular pathway n Connects the hypothalamus with parasympathetic and sympathetic nuclei.

25. Efferents: To autonomous nervous system medulla: а) parasympathetic nucleus of n. vagus б) cells projecting to sympathetic nuclei in the spinal cord. Control of heart rate, vasoconstriction, digestion, sweating etc.. Endocrine signals to/through pituitary gland а) axons to neurohypophysis to release oxitocin & vasopressin; б) releasing factors into the vessels of adenohypophysis. Hypoth can control any endocrine gland, change blood pressure (vasopressin and vasoconstriction), body temperature, metabolism (TSH) and epinephrine level (ACTH).

28. Blood pressure, temperature, water and electrolyte balance, weight are maintained within optimal values. Hypothalamus = Homeostasis

29. n Autonomous, endocrine, emotional and somatic functions n Serves three basic systems: –Autonomic nervous system –Endocrine system –Lymbic system n Maintains homeostasis of the body Controls

30. Function 1. Autonomous control - anterior region stimulates parasympathetic function - anterior region stimulates parasympathetic function - posterior region stimulates sympathetic function - posterior region stimulates sympathetic function 2. Thermoregulation - anterior region maintains bogy temperature - anterior region maintains bogy temperature - posterior region stimulates production and preserving heat - posterior region stimulates production and preserving heat 3. Maintaining water balance а. Nucleus ventromedialis – center of satiety а. Nucleus ventromedialis – center of satiety б. Nucleus hypothalamicus lateralis – center of hunger 4. Liberins and statins - produced from nucleus arcuatus - produced from nucleus arcuatus - transported to the portal system of adenohypophysis - transported to the portal system of adenohypophysis - control hormon production in the adenohypophysis - control hormon production in the adenohypophysis

31. Functional characteristics

32. Subthalamus

33. General characteristics n Vaguely delineated area between midbrain, thalamus, hypothalamus, capsula interna and ІІІ ventricle. n Contains fibers and nuclear structures - zona incerta, nucleus subthalamicus, Forel fields, nuclei reticulares n Connected mainly with somatomotor functions

36. Nuclear structures n Nucleus subthalamicus (Luys) –Well defined lying on capsula interna –Rostral penetration of sustantia nigra –Connected bilaterally with globus pallidus n Nuclei reticulares –Small groups and extensions of cells n Zona incerta - continuation of nucleus reticularis thalami n Fields H of Forel (prerubral): –H1 of Forel - between thalamus and zona inserta –H2 of Forel - between nucl. subthalamicus and zona inserta

38. A. Fasciculus thalamicus (in H1 field of Forel) 1. Lemniscus medialis 2. Tractus dentatothalamicus 3. Tractus pallidothalamicus 4. Bundle of reticular fibers connecting brainstem with diencephalon B. Fasciculus lenticularis (in H2 field of Forel) - Pallidothalamic fibers through capsula interna C. Ansa lenticularis - Fibers from globus pallidus (mainly pallidothalamic) beneath capsula interna D. Fasciculus subthalamicus – bidirectional fibers between globus pallidus and nucleus subthalamicus Fibers