1. Case 4 F, 70 ys, lower leg Erythematous patch Clinical suspicious: pemphigoid? Patient followed by Department of Oncology

2. Punch biopsy

9. CD20

10. CD3

12. CD79a

13. CD5

14. CD23

15. CD43

16. Mib-1

17. Further clinical information  History of B-CLL FINAL DIAGNOSIS FINAL DIAGNOSIS Cutaneous localization of B-CLL Cutaneous localization of B-CLL CD20+; CD79a+; CD5+; CD23+; CD43+; CD3-. CD20+; CD79a+; CD5+; CD23+; CD43+; CD3-.

18. Follow-up: spontaneous resolution of the lesion (Kazakov D et al. Dermatology 2003; 207: 111-115)  H&E: monomorphous lymphocytes, small size but with hyperchromatic nuclei  Immunohistochemistry: large panel r/o Mantle Cell Lymphoma (cyclin D1-; low Mib-1) r/o Mantle Cell Lymphoma (cyclin D1-; low Mib-1)  Clinical information: not given, at least directly!