Variations on a Theme Living organisms are distinguished by their ability to reproduce their own kind Genetics is the scientific study of heredity and.

Variations on a Theme Living organisms are distinguished by their ability to reproduce their own kind Genetics is the scientific study of heredity and variation Heredity is the transmission of traits from one generation to the next Variation is demonstrated by the differences in appearance that offspring show from parents and siblings

Figure 13.1 What accounts for family resemblance?

Inheritance of Genes Genes are the units of heredity, and are made up of segments of DNA Genes are passed to the next generation through reproductive cells called gametes (sperm and eggs) Each gene has a specific location called a locus on a certain chromosome Most DNA is packaged into chromosomes One set of chromosomes is inherited from each parent

Comparison of Asexual and Sexual Reproduction
In asexual reproduction, one parent produces genetically identical offspring by mitosis A clone is a group of genetically identical individuals from the same parent In sexual reproduction, two parents give rise to offspring that have unique combinations of genes inherited from the two parents

0.5 mm Parent Bud (a) Hydra (b) Redwoods
Figure 13.2 Asexual reproduction in two multicellular organisms Parent Bud (a) Hydra (b) Redwoods

Fertilization and meiosis alternate in sexual life cycles
A life cycle is the generation-to-generation sequence of stages in the reproductive history of an organism

Sets of Chromosomes in Human Cells
Human somatic cells (any cell other than a gamete) have 23 pairs of chromosomes A karyotype is an ordered display of the pairs of chromosomes from a cell The two chromosomes in each pair are called homologous chromosomes, or homologs Chromosomes in a homologous pair are the same length and carry genes controlling the same inherited characters

APPLICATION Figure 13.3 Preparing a karyotype

TECHNIQUE 5 µm Pair of homologous replicated chromosomes Centromere
Figure 13.3 Preparing a karyotype Sister chromatids Metaphase chromosome

The sex chromosomes are called X and Y
Human females have a homologous pair of X chromosomes (XX) Human males have one X and one Y chromosome The 22 pairs of chromosomes that do not determine sex are called autosomes

Each pair of homologous chromosomes includes one chromosome from each parent
The 46 chromosomes in a human somatic cell are two sets of 23: one from the mother and one from the father A diploid cell (2n) has two sets of chromosomes For humans, the diploid number is 46 (2n = 46)

Key Maternal set of chromosomes (n = 3) 2n = 6 Paternal set of
Two sister chromatids of one replicated chromosome Figure 13.4 Describing chromosomes Centromere Two nonsister chromatids in a homologous pair Pair of homologous chromosomes (one from each set)

A gamete (sperm or egg) contains a single set of chromosomes, and is haploid (n)
For humans, the haploid number is 23 (n = 23) Each set of 23 consists of 22 autosomes and a single sex chromosome In an unfertilized egg (ovum), the sex chromosome is X In a sperm cell, the sex chromosome may be either X or Y

Behavior of Chromosome Sets in the Human Life Cycle
Fertilization is the union of gametes (the sperm and the egg) The fertilized egg is called a zygote and has one set of chromosomes from each parent The zygote produces somatic cells by mitosis and develops into an adult

At sexual maturity, the ovaries and testes produce haploid gametes
Gametes are the only types of human cells produced by meiosis, rather than mitosis Meiosis results in one set of chromosomes in each gamete Fertilization and meiosis alternate in sexual life cycles to maintain chromosome number

Multicellular diploid adults (2n = 46)
Key Haploid gametes (n = 23) Haploid (n) Egg (n) Diploid (2n) Sperm (n) MEIOSIS FERTILIZATION Figure 13.5 The human life cycle Ovary Testis Diploid zygote (2n = 46) Mitosis and development Multicellular diploid adults (2n = 46)

The Variety of Sexual Life Cycles
The alternation of meiosis and fertilization is common to all organisms that reproduce sexually The three main types of sexual life cycles differ in the timing of meiosis and fertilization

In animals, meiosis produces gametes, which undergo no further cell division before fertilization
Gametes are the only haploid cells in animals Gametes fuse to form a diploid zygote that divides by mitosis to develop into a multicellular organism

Figure 13.6 Three types of sexual life cycles
Key Haploid (n) Haploid unicellular or multicellular organism Diploid (2n) Haploid multicellular organism (gametophyte) n Gametes n n Mitosis n Mitosis Mitosis n Mitosis n n n n n MEIOSIS FERTILIZATION Spores n Figure 13.6 Three types of sexual life cycles Gametes n Gametes n MEIOSIS FERTILIZATION Zygote MEIOSIS FERTILIZATION 2n 2n 2n 2n Diploid multicellular organism Zygote Diploid multicellular organism (sporophyte) 2n Mitosis Mitosis Zygote (a) Animals (b) Plants and some algae (c) Most fungi and some protists

Key Haploid (n) Diploid (2n) Gametes n n n MEIOSIS FERTILIZATION
Figure 13.6a Three types of sexual life cycles—animals Zygote 2n 2n Diploid multicellular organism Mitosis (a) Animals

Plants and some algae exhibit an alternation of generations
This life cycle includes both a diploid and haploid multicellular stage The diploid organism, called the sporophyte, makes haploid spores by meiosis

Each spore grows by mitosis into a haploid organism called a gametophyte
A gametophyte makes haploid gametes by mitosis Fertilization of gametes results in a diploid sporophyte

(b) Plants and some algae
Key Haploid (n) Haploid multicellular organism (gametophyte) Diploid (2n) Mitosis Mitosis n n n n n Spores Gametes Figure 13.6b Three types of sexual life cycles—plants and some algae MEIOSIS FERTILIZATION 2n 2n Zygote Diploid multicellular organism (sporophyte) Mitosis (b) Plants and some algae

In most fungi and some protists, the only diploid stage is the single-celled zygote; there is no multicellular diploid stage The zygote produces haploid cells by meiosis Each haploid cell grows by mitosis into a haploid multicellular organism The haploid adult produces gametes by mitosis

Haploid unicellular or multicellular organism Diploid (2n)
Key Haploid (n) Haploid unicellular or multicellular organism Diploid (2n) Mitosis Mitosis n n n n Figure 13.6c Three types of sexual life cycles—most fungi and some protists Gametes n MEIOSIS FERTILIZATION 2n Zygote (c) Most fungi and some protists

Depending on the type of life cycle, either haploid or diploid cells can divide by mitosis
However, only diploid cells can undergo meiosis In all three life cycles, the halving and doubling of chromosomes contributes to genetic variation in offspring

Meiosis reduces the number of chromosome sets from diploid to haploid
Like mitosis, meiosis is preceded by the replication of chromosomes Meiosis takes place in two sets of cell divisions, called meiosis I and meiosis II The two cell divisions result in four daughter cells, rather than the two daughter cells in mitosis Each daughter cell has only half as many chromosomes as the parent cell

The Stages of Meiosis In the first cell division (meiosis I), homologous chromosomes separate Meiosis I results in two haploid daughter cells with replicated chromosomes; it is called the reductional division In the second cell division (meiosis II), sister chromatids separate Meiosis II results in four haploid daughter cells with unreplicated chromosomes; it is called the equational division

Figure 13.7 Overview of meiosis: how meiosis reduces chromosome number
Interphase Homologous pair of chromosomes in diploid parent cell Chromosomes replicate Homologous pair of replicated chromosomes Sister chromatids Diploid cell with replicated chromosomes Figure 13.7 Overview of meiosis: how meiosis reduces chromosome number Meiosis I 1 Homologous chromosomes separate Haploid cells with replicated chromosomes Meiosis II 2 Sister chromatids separate Haploid cells with unreplicated chromosomes

The single centrosome replicates, forming two centrosomes
Meiosis I is preceded by interphase, in which chromosomes are replicated to form sister chromatids The sister chromatids are genetically identical and joined at the centromere The single centrosome replicates, forming two centrosomes For the Cell Biology Video Meiosis I in Sperm Formation, go to Animation and Video Files.

Prophase I Metaphase I Anaphase I Centrosome (with centriole pair)
Telophase I and Cytokinesis Prophase I Metaphase I Anaphase I Centrosome (with centriole pair) Sister chromatids remain attached Centromere (with kinetochore) Sister chromatids Chiasmata Spindle Metaphase plate Figure 13.8 The meiotic division of an animal cell Cleavage furrow Homologous chromosomes Homologous chromosomes separate Fragments of nuclear envelope Microtubule attached to kinetochore

Prophase I Prophase I typically occupies more than 90% of the time required for meiosis Chromosomes begin to condense In synapsis, homologous chromosomes loosely pair up, aligned gene by gene

In crossing over, nonsister chromatids exchange DNA segments
Each pair of chromosomes forms a tetrad, a group of four chromatids Each tetrad usually has one or more chiasmata, X-shaped regions where crossing over occurred

Metaphase I In metaphase I, tetrads line up at the metaphase plate, with one chromosome facing each pole Microtubules from one pole are attached to the kinetochore of one chromosome of each tetrad Microtubules from the other pole are attached to the kinetochore of the other chromosome

Prophase I Metaphase I Centrosome (with centriole pair) Centromere
(with kinetochore) Sister chromatids Chiasmata Spindle Metaphase plate Figure 13.8 The meiotic division of an animal cell Homologous chromosomes Fragments of nuclear envelope Microtubule attached to kinetochore

Anaphase I In anaphase I, pairs of homologous chromosomes separate One chromosome moves toward each pole, guided by the spindle apparatus Sister chromatids remain attached at the centromere and move as one unit toward the pole

Telophase I and Cytokinesis
In the beginning of telophase I, each half of the cell has a haploid set of chromosomes; each chromosome still consists of two sister chromatids Cytokinesis usually occurs simultaneously, forming two haploid daughter cells

In animal cells, a cleavage furrow forms; in plant cells, a cell plate forms
NO chromosome replication occurs between the end of meiosis I and the beginning of meiosis II because the chromosomes are already replicated

Telophase I and Cytokinesis
Anaphase I Sister chromatids remain attached Figure 13.8 The meiotic division of an animal cell Homologous chromosomes separate Cleavage furrow

Division in meiosis II also occurs in four phases:
– Prophase II – Metaphase II – Anaphase II – Telophase II and cytokinesis Meiosis II is very similar to mitosis

Telophase II and Cytokinesis
Prophase II Metaphase II Anaphase II Figure 13.8 The meiotic division of an animal cell Sister chromatids separate Haploid daughter cells forming

Metaphase II In metaphase II, the sister chromatids are arranged at the metaphase plate Because of crossing over in meiosis I, the two sister chromatids of each chromosome are no longer genetically identical The kinetochores of sister chromatids attach to microtubules extending from opposite poles

Prophase II Metaphase II
Figure 13.8 The meiotic division of an animal cell

Anaphase II In anaphase II, the sister chromatids separate The sister chromatids of each chromosome now move as two newly individual chromosomes toward opposite poles

Telophase II and Cytokinesis
In telophase II, the chromosomes arrive at opposite poles Nuclei form, and the chromosomes begin decondensing

Cytokinesis separates the cytoplasm
At the end of meiosis, there are four daughter cells, each with a haploid set of unreplicated chromosomes Each daughter cell is genetically distinct from the others and from the parent cell

Telephase II and Cytokinesis
Anaphase II Figure 13.8 The meiotic division of an animal cell Sister chromatids separate Haploid daughter cells forming

A Comparison of Mitosis and Meiosis
Mitosis conserves the number of chromosome sets, producing cells that are genetically identical to the parent cell Meiosis reduces the number of chromosomes sets from two (diploid) to one (haploid), producing cells that differ genetically from each other and from the parent cell The mechanism for separating sister chromatids is virtually identical in meiosis II and mitosis

Replicated chromosome
MITOSIS MEIOSIS MEIOSIS I Parent cell Chiasma Chromosome replication Chromosome replication Prophase Prophase I Homologous chromosome pair 2n = 6 Replicated chromosome Metaphase Metaphase I Figure 13.9 A comparison of mitosis and meiosis in diploid cells Anaphase Telophase Anaphase I Telophase I Haploid n = 3 Daughter cells of meiosis I 2n 2n MEIOSIS II Daughter cells of mitosis n n n n Daughter cells of meiosis II

Figure 13.9 A comparison of mitosis and meiosis in diploid cells
SUMMARY Property Mitosis Meiosis DNA replication Occurs during interphase before mitosis begins Occurs during interphase before meiosis I begins Number of divisions One, including prophase, metaphase, anaphase, and telophase Two, each including prophase, metaphase, anaphase, and telophase Synapsis of homologous chromosomes Figure 13.9 A comparison of mitosis and meiosis in diploid cells Does not occur Occurs during prophase I along with crossing over between nonsister chromatids; resulting chiasmata hold pairs together due to sister chromatid cohesion Number of daughter cells and genetic composition Two, each diploid (2n) and genetically identical to the parent cell Four, each haploid (n), containing half as many chromosomes as the parent cell; genetically different from the parent cell and from each other Role in the animal body Enables multicellular adult to arise from zygote; produces cells for growth, repair, and, in some species, asexual reproduction Produces gametes; reduces number of chromosomes by half and introduces genetic variability among the gametes

Three events are unique to meiosis, and all three occur in meiosis l:
– Synapsis and crossing over in prophase I: Homologous chromosomes physically connect and exchange genetic information – At the metaphase plate, there are paired homologous chromosomes (tetrads), instead of individual replicated chromosomes – At anaphase I, it is homologous chromosomes, instead of sister chromatids, that separate

Sister chromatid cohesion allows sister chromatids of a single chromosome to stay together through meiosis I Protein complexes called cohesins are responsible for this cohesion In mitosis, cohesins are cleaved at the end of metaphase In meiosis, cohesins are cleaved along the chromosome arms in anaphase I (separation of homologs) and at the centromeres in anaphase II (separation of sister chromatids)

Genetic variation produced in sexual life cycles contributes to evolution
Mutations (changes in an organism’s DNA) are the original source of genetic diversity Mutations create different versions of genes called alleles Reshuffling of alleles during sexual reproduction produces genetic variation

Origins of Genetic Variation Among Offspring
The behavior of chromosomes during meiosis and fertilization is responsible for most of the variation that arises in each generation Three mechanisms contribute to genetic variation: Independent assortment of chromosomes Crossing over Random fertilization

Independent Assortment of Chromosomes
Homologous pairs of chromosomes orient randomly at metaphase I of meiosis In independent assortment, each pair of chromosomes sorts maternal and paternal homologues into daughter cells independently of the other pairs

The number of combinations possible when chromosomes assort independently into gametes is 2n, where n is the haploid number For humans (n = 23), there are more than million (223) possible combinations of chromosomes

Possibility 1 Possibility 2 Two equally probable arrangements of
chromosomes at metaphase I Figure The independent assortment of homologous chromosomes in meiosis Metaphase II Daughter cells Combination 1 Combination 2 Combination 3 Combination 4

Crossing Over Crossing over produces recombinant chromosomes, which combine genes inherited from each parent Crossing over begins very early in prophase I, as homologous chromosomes pair up gene by gene

In crossing over, homologous portions of two nonsister chromatids trade places
Crossing over contributes to genetic variation by combining DNA from two parents into a single chromosome

Recombinant chromosomes
Prophase I of meiosis Nonsister chromatids held together during synapsis Pair of homologs Chiasma Centromere TEM Figure The results of crossing over during meiosis Anaphase I Anaphase II Daughter cells Recombinant chromosomes

Random Fertilization Random fertilization adds to genetic variation because any sperm can fuse with any ovum (unfertilized egg) The fusion of two gametes (each with 8.4 million possible chromosome combinations from independent assortment) produces a zygote with any of about 70 trillion diploid combinations

The Evolutionary Significance of Genetic Variation Within Populations
Natural selection results in the accumulation of genetic variations favored by the environment Sexual reproduction contributes to the genetic variation in a population, which originates from mutations Crossing over adds even more variation Each zygote has a unique genetic identity

Animations and Videos Meiosis Tutorial Meiosis - 1 Meiosis - 2
Stages of Meiosis Anaphase Separase Spermatogenesis Production of Male and Female Gametes Polar Body Formation

Animations and Videos Random Orientation of Chromosomes During Meiosis
Independent Assortment Independent Assortment and Gamete Diversity Alleles That Do Not Assort Independently Comparison of Mitosis and Meiosis Bozeman - Diploid vs. Haploid Cells Activity- Mitosis and Meiosis Bozeman - Mitosis and Meiosis Simulation

Animations and Videos Meiosis - Nondisjunction – 1
Crossing Over Changes in Chromosome Structure The Consequence of Inversion Bozeman - Cell Cycle (Mitosis and Meiosis) X Inactivation Bozeman - X Inactivation

Animations and Videos Density-Dependent Inhibition
Cytotoxic T Lymphocytes Attack a Melanoma Cell Metastasis of a Cancer Amniocentesis Animation Chorionic Villus Sampling Karyotype Animation Human Melanoma Cells Dividing Chapter Quiz Questions – 1 Chapter Quiz Questions – 2

Which of the following transmits genes from both parents to child, or from one generation of a family to another? DNA gametes somatic cells mitosis nucleotides Answer: B

Which of the following transmits genes from both parents to child, or from one generation of a family to another? DNA gametes somatic cells mitosis nucleotides 69

Fertilization is to zygote as meiosis is to which of the following?
mitosis diploid chromosome replication gamete Answer: E 70

Fertilization is to zygote as meiosis is to which of the following?
mitosis diploid chromosome replication gamete 71

Privet shrubs and humans each have a diploid number of 46 chromosomes per cell. Why are the two species so dissimilar? Privet chromosomes undergo only mitosis. Privet chromosomes are shaped differently. Human chromosomes have genes grouped together differently. The two species have appreciably different genes. Privets do not have sex chromosomes. Answer: D 72

Privet shrubs and humans each have a diploid number of 46 chromosomes per cell. Why are the two species so dissimilar? Privet chromosomes undergo only mitosis. Privet chromosomes are shaped differently. Human chromosomes have genes grouped together differently. The two species have appreciably different genes. Privets do not have sex chromosomes. 73

Why is it more practical to prepare karyotypes by viewing somatic diploid cells rather than haploid gametes? Somatic diploid cells do not contain organelles to interfere with karyotyping. Both sets of chromosomes, which are present in somatic diploid cells, need to be examined. DNA in haploid gametes will not stain. The chromosomes are larger in a somatic diploid cell. Haploid gametes do not have sex chromosomes. Answer: B 74

Why is it more practical to prepare karyotypes by viewing somatic diploid cells rather than haploid gametes? Somatic diploid cells do not contain organelles to interfere with karyotyping. Both sets of chromosomes, which are present in somatic diploid cells, need to be examined. DNA in haploid gametes will not stain. The chromosomes are larger in a somatic diploid cell. Haploid gametes do not have sex chromosomes. 75

Diploid cells may undergo either mitosis or meiosis
Diploid cells may undergo either mitosis or meiosis. Haploid cells may undergo mitosis (for certain species) but not meiosis because the sister chromatids cannot separate. the synaptonemal complex is too strong. crossing over has occurred. cohesins are no longer present. homologous chromosomes cannot pair. Answer: E 76

Diploid cells may undergo either mitosis or meiosis
Diploid cells may undergo either mitosis or meiosis. Haploid cells may undergo mitosis (for certain species) but not meiosis because the sister chromatids cannot separate. the synaptonemal complex is too strong. crossing over has occurred. cohesins are no longer present. homologous chromosomes cannot pair. Answer: E 77

How and at what stage do chromosomes undergo independent assortment?
meiosis I pairing of homologs anaphase I separation of homologs meiosis II separation of homologs meiosis I metaphase alignment meiosis I telophase separation Answer: D 78

How and at what stage do chromosomes undergo independent assortment?
meiosis I pairing of homologs anaphase I separation of homologs meiosis II separation of homologs meiosis I metaphase alignment meiosis I telophase separation 79

What allows sister chromatids to separate in which phase of meiosis?
release of cohesin along sister chromatid arms in anaphase I crossing over of chromatids in prophase I release of cohesin at centromeres in anaphase I release of cohesin at centromeres in anaphase II crossing over of homologs in prophase I Answer: D 80

What allows sister chromatids to separate in which phase of meiosis?
release of cohesin along sister chromatid arms in anaphase I crossing over of chromatids in prophase I release of cohesin at centromeres in anaphase I release of cohesin at centromeres in anaphase II crossing over of homologs in prophase I 81

Gametes produced from one meiotic event
are genetically identical to each other. each have the same chromosome number. are genetically identical to the cells produced from meiosis I. are genetically identical to the parent cell. each have the same mutations. Answer: B 82

Gametes produced from one meiotic event
are genetically identical to each other. each have the same chromosome number. are genetically identical to the cells produced from meiosis I. are genetically identical to the parent cell. each have the same mutations. 83

Crossing over begins to occur during
anaphase I anaphase II prophase I metaphase II telophase II Answer: C 84

Crossing over begins to occur during
anaphase I anaphase II prophase I metaphase II telophase II Answer: C 85

In this cell, what phase is represented?
mitotic metaphase meiosis I anaphase meiosis I metaphase meiosis II anaphase meiosis II metaphase Answer: C 86

In this cell, what phase is represented?
mitotic metaphase meiosis I anaphase meiosis I metaphase meiosis II anaphase meiosis II metaphase 87

Scientific Skills Exercise
When nutrients are low, cells of the budding yeast (Saccharomyces cerevisiae) exit the mitotic cell cycle and enter meiosis. In this exercise, you will track the DNA content of a population of yeast cells as they progress through meiosis. Researchers grew a culture of yeast cells in a nutrient-rich medium and then transferred them to a nutrient-poor medium to induce meiosis. At different times after induction, the DNA content per cell was measured in a sample of the cells, and the average DNA content per cell was recorded in femtograms (fg; 1 femtogram  1 × 10–15 gram). Their data are shown in the table to the right.

Most of the yeast cells in the culture were in G1 of the cell cycle before being moved to the nutrient-poor medium to induce meiosis. How many femtograms of DNA are there in a yeast cell in G1? Estimate this value from the data in the table. 12 fg 24 fg 40 fg 48 fg Answer: B

How many femtograms of DNA are present in a cell in G2?
12 fg 24 fg 40 fg 48 fg Answer: D

How many femtograms of DNA are present in a cell at the end of meiosis I?
12 fg 24 fg 40 fg 48 fg Answer: B

How many femtograms of DNA are present in a cell at the end of meiosis I?
12 fg 24 fg 40 fg 48 fg

How many femtograms of DNA are present in a cell at the end of meiosis II?
12 fg 24 fg 40 fg 48 fg Answer: A

A graph with labels indicating the different phases of the meiotic cell cycle (MI  meiosis I; MII  meiosis II) is shown to the right, based on the data from the table. Think carefully about the point on the graph where the line at the highest value begins to slope downward, indicated by the red arrow. What specific point of meiosis does this “corner” represent? Answer: C metaphase I prophase II cytokinesis anaphase I

A graph with labels indicating the different phases of the meiotic cell cycle (MI  meiosis I; MII  meiosis II) is shown to the right, based on the data from the table. Think carefully about the point on the graph where the line at the highest value begins to slope downward, indicated by the red arrow. What specific point of meiosis does this “corner” represent? metaphase I prophase II cytokinesis anaphase I

Based on this data, how much DNA is present in a gamete of Saccharomyces cerevisiae?
12 fg 24 fg 48 fg Answer: A

Based on this data, how much DNA is present in a gamete of Saccharomyces cerevisiae?
12 fg 24 fg 48 fg

0.08 Mb (8.0  104 base pairs) 1.2 Mb (1.2  106 base pairs)
Given the fact that 1 fg of DNA  9.78  105 base pairs (on average), you can convert the amount of DNA per cell to the length of DNA in numbers of base pairs. Millions of base pairs (Mb) is the standard unit for expressing genome size. Calculate the approximate number of base pairs of DNA in the haploid yeast genome. Answer: C 0.08 Mb (8.0  104 base pairs) 1.2 Mb (1.2  106 base pairs) 12 Mb (12  106 base pairs) 23 Mb (23  106 base pairs)

0.08 Mb (8.0  104 base pairs) 1.2 Mb (1.2  106 base pairs)
Given the fact that 1 fg of DNA  9.78  105 base pairs (on average), you can convert the amount of DNA per cell to the length of DNA in numbers of base pairs. Millions of base pairs (Mb) is the standard unit for expressing genome size. Calculate the approximate number of base pairs of DNA in the haploid yeast genome. 0.08 Mb (8.0  104 base pairs) 1.2 Mb (1.2  106 base pairs) 12 Mb (12  106 base pairs) 23 Mb (23  106 base pairs)

Given the fact that 1 fg of DNA  9
Given the fact that 1 fg of DNA  9.78  105 base pairs (on average), you can estimate the rate of DNA synthesis in Saccharomyces cerevisiae. Approximately how many base pairs per minute were synthesized during the S phase of these yeast cells? 0.19 (1.9  10–1) base pair per minute 100,000 (1.0  105) base pairs per minute 200,000 (2.0  105) base pairs per minute 11,000,000 (11.0  106) base pairs per minute Answer: C Because the S phase took place from approximately the 1-hour mark to the 3-hour mark, start by finding the difference between the amount of DNA at 3 hours and the amount at 1 hour: 47.0 fg – 24.0 fg = 23.0 fg. Now calculate the rate of fg synthesized per minute by dividing that amount by the number of minutes in two hours: 23.0 fg/ 120 minutes = fg/min. Finally, you need to convert from fg/min to base pairs/min: fg/min × (9.78 × 105 base pairs/fg) = 187,800, or approximately 200,000 base pairs/min.

Variations on a Theme Living organisms are distinguished by their ability to reproduce their own kind Genetics is the scientific study of heredity and.

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Variations on a Theme Living organisms are distinguished by their ability to reproduce their own kind Genetics is the scientific study of heredity and.

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Presentation on theme: "Variations on a Theme Living organisms are distinguished by their ability to reproduce their own kind Genetics is the scientific study of heredity and."— Presentation transcript:

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