1. Mesothelioma: your questions and future treatment options Susie Harden 1/4/11

2. Future possibilities in Cambridge n First line studies n Second line studies n Phase 1 studies n Biobank: potential for individually tailored treatments in the future?

3. First line studies coming soon n MESO 2: phase II study of adding vorinostat to pemetrexed /cisplatin [this agent is a histone deacetylase inhibitor and acts to ‘unblock’ certain genes in tumour cells n ADAM: Phase II study of pegylated arginine deaminase/placebo [when chemotherapy not indicated in ASS (arginosuccinate synthetase) negative patients. (this agent depletes tumours of an essential amino acid – arginine)]

4. Secondline studies No standard treatment but re-challenge with pemetrexed if good first time response accepted No imminent trials in Cambridge

5. Phase 1 studies in Cambridge n S222611 SHINOGI [a dual EGFR and HER2 small molecule inhibitor] n Radiotherapy (your feedback please!) Tomotherapy dose-wash diagram

6. Over to you! Any questions? Any suggestions?