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Glycoproteins and Proteoglycans Eric Niederhoffer SIU-SOM Glycoproteins Proteins conjugated to saccharides lacking a serial repeat unit Proteoglycans Proteins.

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Presentation on theme: "Glycoproteins and Proteoglycans Eric Niederhoffer SIU-SOM Glycoproteins Proteins conjugated to saccharides lacking a serial repeat unit Proteoglycans Proteins."— Presentation transcript:

1 Glycoproteins and Proteoglycans Eric Niederhoffer SIU-SOM Glycoproteins Proteins conjugated to saccharides lacking a serial repeat unit Proteoglycans Proteins conjugated to polysaccharides with serial repeat units Protein >> carbohydrate Carbohydrate >> protein Glycosaminoglycans Mucopolysaccharides Repeat unit HexN and HexUA

2 Glycopeptide bonds Type I Type IIType III N-Glycosyl linkage to Asn O-Glycosyl linkage to Ser (Thr)O-Glycosyl linkage to 5-HOLys Glc NAc Asn Glc NAc Ser HOLys Glc

3 Glycosaminoglycans Hyaluronate No protein link No sulfate  -1,3 glycosidic linkage GlcUAGlcNAc  -1,3  -1,4

4 Glycosaminoglycans Chondroitin sulfate GlcUA-Gal-Gal-Xyl-O-Ser link Sulfate at 4 or 6 C of GalNAc  -1,3 glycosidic linkage GlcUAGalNAc  -1,3  -1,4

5 Glycosaminoglycans Dermatan sulfate IdUA with some GlcUA Sulfate at 4 or 6 C of GalNAc  -1,3 glycosidic linkage IdUAGalNAc  -1,3  -1,4

6 Glycosaminoglycans Heparin GlcN and GlcUA or IdUA N and O sulfate (C2,3,6)  -1,4 glycosidic linkage GlcUAGlcNAc  -1,4 Heparan sulfate > NAc < N and O sulfate

7 Glycosaminoglycans Keratan sulfate I GlcNAc and Gal (no UA) Sulfate on C6 of Gal or HexN  -1,4 glycosidic linkage GlcUAGlcNAc  -1,4  -1,3 Keratan sulfate IIGalNAc-O-Ser or Thr


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