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Published byGodfrey Strickland Modified over 9 years ago
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Glycoproteins and Proteoglycans Eric Niederhoffer SIU-SOM Glycoproteins Proteins conjugated to saccharides lacking a serial repeat unit Proteoglycans Proteins conjugated to polysaccharides with serial repeat units Protein >> carbohydrate Carbohydrate >> protein Glycosaminoglycans Mucopolysaccharides Repeat unit HexN and HexUA
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Glycopeptide bonds Type I Type IIType III N-Glycosyl linkage to Asn O-Glycosyl linkage to Ser (Thr)O-Glycosyl linkage to 5-HOLys Glc NAc Asn Glc NAc Ser HOLys Glc
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Glycosaminoglycans Hyaluronate No protein link No sulfate -1,3 glycosidic linkage GlcUAGlcNAc -1,3 -1,4
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Glycosaminoglycans Chondroitin sulfate GlcUA-Gal-Gal-Xyl-O-Ser link Sulfate at 4 or 6 C of GalNAc -1,3 glycosidic linkage GlcUAGalNAc -1,3 -1,4
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Glycosaminoglycans Dermatan sulfate IdUA with some GlcUA Sulfate at 4 or 6 C of GalNAc -1,3 glycosidic linkage IdUAGalNAc -1,3 -1,4
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Glycosaminoglycans Heparin GlcN and GlcUA or IdUA N and O sulfate (C2,3,6) -1,4 glycosidic linkage GlcUAGlcNAc -1,4 Heparan sulfate > NAc < N and O sulfate
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Glycosaminoglycans Keratan sulfate I GlcNAc and Gal (no UA) Sulfate on C6 of Gal or HexN -1,4 glycosidic linkage GlcUAGlcNAc -1,4 -1,3 Keratan sulfate IIGalNAc-O-Ser or Thr
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