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Published byMartin Randall Modified over 9 years ago
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SBI 4U November 14 th, 2012
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1. What is the central dogma? 2. Where does translation occur in the cell? 3. Where does transcription occur in the cell? 4. In simple words, what is translation?
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1. Initiation 2. Elongation 3. Termination
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Locates the correct spot on the original DNA template where transcription is to begin Promoter sequence: a particular nucleotide sequence on the DNA molecule provides a binding site for RNA polymerase
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Strings of A’s and T’s RNA polymerase can only transcribe in one direction RNA polymerase opens up a section of the DNA to be transcribed
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Copies the correct number of nucleotides from the DNA template onto a particular type of RNA molecule called messenger RNA (mRNA)
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RNA polymerase works from 5’ to 3’ As RNA polymerase passes, DNA helix re- forms and the mRNA strand separates from its template DNA strand Template strand: strand used for transcription Coding strand: strand that is not used for transcription identical to the template strand, except for ___________
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Signals the right place to stop the copying process to make sure the mRNA molecule contains the complete set of instructions from the gene
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Once transcription has been successfully initiated, the RNA polymerase continues along the DNA molecule until it encounters terminator sequences After termination mRNA separates from the RNA polymerase Prokaryotes vs. Eukaryotes
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Capping and Tailing: 5’ cap added to the 5’ end of the pre-mRNA modified G nucleotide Poly-A tail added to the 3’ end long series of A nucleotides
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5’ cap and poly-A tail help protect mRNA from enzymes in the cytoplasm that may break it down. Also serve as signals. Poly-A tail also helps with transport of the mRNA
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mRNA Splicing: Exons: form part of the instructions for protein synthesis Introns: intervening, non-coding nucleotide sequences
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mRNA Splicing: Spliceosomes: Cut out the introns and join the exons together mRNA molecule is formed and is now ready to leave the nucleus
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Page: 249 Questions 1, 2, 3, 5, 9
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