1. Part 2: Introduction to NIRx Hardware and Software

2. NIRS Software Basics

3. NIRx Software NIRStar Instrument-Control Software
nirsLAB Topographic Analysis Software
NAVI Tomographic Imaging Software

4. NIRStar Software – Instrument Control & Recording
Open license
BCI/Neurofeedback
Real-time cortical viewing
Real-time data streams
Real-time block averages
Hyperscanning
Optode position registration
NIRStar realtime cortical activation viewing.

5. NIRStar Channel Setup
The NIRStar Channel Setup gives users the chance to precisely define an illumination pattern: the time-multiplexing order which the sources illuminate in one full scan
Sources used in measurement
Steps used per full scan
Detectors used in measurement
Illumination pattern of sources firing per scan
Scans per sec. (sampling rate/ temporal resolution)

6. NIRStar Topo Layout
The topolayout gives a simple 2D representation of the montage layout, facilitating easy viewing of channel activity. Numbering is issued with sources listed first, then detectors (e.g., 1-2 is source #1 paired with detector #2, etc.)

7. NIRStar Probe Setup Ultility
The probe setup utility gives a 3D representation for the channel activation.

8. NIRStar Realtime Block Averages

9. NIRStar Realtime Data Streams

10. NIRStar Realtime BCI/SDK

11. NIRx Product Overview nirsLAB Software – Topographic Analysis
Open licensed
Sophisticated topographic data analysis
Detailed cortical views with activation maps
Flexible options for data manipulation (spike removal, filtering, etc.)
SPM1 and SPM2 (group-level) analysis

12. Software – nirsLAB - Topographic Analysis

13. NIRx Product Overview Software – nirsLAB - Topographic Analysis
SPM results shown right for right-leg balance.
The results can be viewed in multiple images, with or without probe and standard EEG locations.
Probes are shown in red (sources) and yellow (detectors).
Right: 2D layout

14. NIRx Product Overview Software – nirsLAB - Topographic Analysis
SPM results shown right for right-leg balance.
3D layout

15. NIRx Product Overview Software – nirsLAB - Topographic Analysis
SPM results shown right for right-leg balance.
High-resolution brain with glass head layout

16. NIRx Product Overview Software – nirsLAB - Topographic Analysis
SPM results shown right for right-leg balance.
MNI brain with glass head layout

17. NIRx Product Overview Software – nirsLAB - Topographic Analysis
In addition to SPM1 and SPM2, nirsLAB allows block average viewing at any given relative time (to the event onset time = 0), including full animations.

18. NIRx Product Overview NAVI Software – Tomographic Analysis
Open licensed
Sophisticated tomographic data analysis
Source analysis from from discrimination
Flexible options for data manipulation (spike removal, filtering, etc.)
Detailed cortical views with activation maps

19. NIRx Product Overview
NAVI – Tomographic Analysis – fNIRS activation on MR scans

20. NAVI Analysis Software

21. NIRS Hardware Overview

22. fNIRS – Hardware Overview
Probes (optodes) for sending (sources) and receiving (detectors) light.
Note: sources may be LED or Laser, depending on the system and application.
detector
(LED) source
Calibration Phantom for testing and setting proper gain settings for detectors (and sources, in some cases)

23. fNIRS – Hardware Overview
Headgear – Retains probes for steady and orthogonal placement against skin.
Amplifier – this unit both powers the sources and detectors. It also digitizes the detector signal.
Also, in some cases, sends and receives TTL trigger pulses

24. NIRx Hardware: Systems and Components

25. NIRx Development
2000
2004
Hyperscanning
2013
Mobile Studies
2012

26. Systems = NIRS Imaging Systems
NIRx Hardware
Headgear = NIRScap
Systems = NIRS Imaging Systems
NIRSport
NIRScout and NIRScout Extended

27. NIRScap - Headgear Concept
Optodes:
- low profile
- variety of solutions
- organized cables
Retaining layer:
- outer cap compression
- adjustable shape
- whole head
Conforming cap:
- free configurations
- multi-modal
- Comfortable

28. NIRScap - Subject Preparation

29. Optodes Optode Placement LED Illuminator
(2-Wavelength -> 760nm & 850nm
Fiber optic Detectors
Optode Placement

30. Applying the retaining cap

31. INSTRUMENT ACCESSORIES

32. Fiber support arm
The fiber support arm system is highly-flexible and relieves cable tension on optodes, increasing comfort and maintaining data quality.

33. Fiber support arm - adjustments

34. Static test phantom
All NIRx systems use the NIRx static phantom for automated procedures that ensure that the system and its components are working properly.
The black case (shown above) provides a dark environment for testing detector and source performance.

35. NIRx SYSTEMS

36. Technical basis of instrumentation
CW measurement (DC Intensity changes)
Most economic, compact, robust technology
Adequate for hemodynamic activation measures
Scalable modularity – from 8-64 detector ch., & source ch.
Simultaneous wavelength illumination
Frequency modulated – 760nm (1.0kHz) & 850nm (1.3KHz) -> Hb/HbO (more, other WL custom options)
Oxy and deoxy => strength over fMRI (only deoxy)
Source switching – Time- Multiplexing
Dynamic measuremement (no competing sources)
Scan rate typically 4-15Hz (62.5Hz max.)

37. Source-Switiching/Time-multiplexing

38. Setup capabilities

39. Tandem mode Two identical instruments (any model)
Channel number doubled
Integration in software, seamless operation as one instrument
NIRSport Tandem Setup (pictured left) for 16-source and 16-detector measurements
NIRScout Extended Tandem Setup (pictured right) for a maximum of 128-source and 64-detector measurements

40. NIRx Product Overview
NIRSport 8-8 and NIRSport Tandem Portable/Wearable System

41. NIRSport Mobile NIRS System
8 Active LED sources
8 Active Detectors
6-hour battery
Runs on power as well
Can be used in Tandem for 16/16 measurements
Ideal for:
Mobile or movement-based studies
Studies requiring extremely lightweight headgear
Child
ASD

42. NIRScout High-Density NIRS System
- Up to 64 sources and 32 detectors
8-bit trigger input and output
Options for Hybrid LED/Laser sources
Can have as few as 8 sources and 4 detectors
Can be used in tandem operation for doubling sources and detectors on a single subject

43. NIRScout High-Density NIRS System
Ideal for:
full-head monitoring
high-density/maximum spatial resolution recordings
Hyperscanning
Multi-modal studies
Animal studies

44. Brain stimulation (TMS, etc.)
NIRScout Extended 8-bit Trigger OUTPUT
EEG
EMG
Brain stimulation (TMS, etc.)
Direct, programmable digital (TTL) control of other systems

45. NIRScout High-Density NIRS System
LED/Laser Hybrid System
Lasers capable of 4-wavelength measurements
Use of new port (shown here) allows choice of either LED or Laser sources

46. NIRScout High-Density NIRS System
LED/Laser Hybrid System
Lasers capable of 4-wavelength measurements
Standard set:
685nm
780nm
808nm
830nm

47. NIRS Instrumentation Highlights
Comprehensive: - Wearable  Large-scale/High-density - Wide range of accessories
Scalable: - Upgradeable, Tandem Mode - Hyperscanning
Integrated:
- Experimental control (Trigger I/O) - Single cross-platform control software - Multi-modal ready (EEG, fMRI, TMS, …)

48. Thanks!
... Questions?