1. DERMAZELAN

2. PILOSEBACEOUS FOLLICLE DISFUNCTION ACNE =

3. DERMAZELAN PATHOGENESIS FUNCTIONAL DISFUNCTIONS OF THE SEBACEOUS GLANDS

4. DERMAZELAN MULTIFACTORIAL ETHIOLOGY HYPERSEBORRHEA FOLICULAR HYPERKERATOSIS FREE RADICALS AND FATTY ACIDS PRODUCTION SAPROFITE MICROFLORA PROLIFERATION

5. DERMAZELAN MIND INTERNAL ORGANS SKIN & MUCOSES THERE IS ALSO A PSYCHOLOGICAL ASPECT INFLUENCING

6. DERMAZELAN VICIOUS CIRCLE

7. DERMAZELAN INFLUENCE OF THE OCCIDENTAL DIET ON ACNE APPEARANCE Ingestion of big amount high glycemic index food + insuline + sebum Aviable Androgens Precursors synthesis in the liver + of androgens synthesis in gonades Increases cell mitosis in all tissues Follicle hyperkeratinization Decreases endogen retinoics efectivity on inhibition of follicle cells proliferation.

8. DERMAZELAN 4 CAUSES INCREASE OF THE CUTANEOUS SEBUM SECRETION ABNORMAL KERATINISATION OF THE HAIR FOLLICLE WALLS INFLAMMATION ANSWERS BACTERIAL INFECTIONS

9. DERMAZELAN SKIN STRUCTURE

10. DERMAZELAN HAIR FOLLICLE STRUCTURE Hair Skin surface sebum follicle Sebaceous gland

11. DERMAZELAN HYPERSEBORRHEA PUBERAL HORMONAL FLUCTUATIONS INCREASE OF THE ANDROGENIC SECRETION OILY SKIN / PROACNEIC SKIN DILATED PORES

12. DERMAZELAN ABNORMAL KERATINISATION HIGHER LEVELS OF ANDROGENS CORNEOCYTES MATURING PROCESS ALTERED HYPERSEBORRHOEA + CRNCT. = PORES OBSTRUCTED DETATCHMENT OF CORNEOCYTES IN GROUPS

13. DERMAZELAN BACTERIAL INFECTIONS MICRO-AIR ATMOSPHERE INSIDE THE SEBACEOUS GLANDS SAPROFITE BACTERIAS MICRO FLORA DEVELOPMENT FATTY ACIDS RELEASE IRRITATION / PROINFLAM. LIPIDS HYDROLISIS BY BACTERIAL ENZYMES (LIPASES)

14. DERMAZELAN INFLAMMATION ANSWERS TISSULAR CHEMIOTACTIC FACTORS + LEUCOCYTES MIGRATION TO THE ALTERED SEBACEOUS GLAND MORE IMPORTANT INFLAMED LESIONS PUS & FREE RADICALS FORMATION

15. DERMAZELAN Puberal increase of testosterone & dihydrotest. secretion Sebaceous gland hyperactivity Increase of sebum production Cell turn over increase Abnormal keratinization Comedones production Increase of P.A. bct Chymiotaxis Intense inflammation Release of P.A. cell mb fragments

16. DERMAZELAN COMEDONES EARLY INITIAL LESION OF THE PROACNEIC SKIN NON- INFLAMED LESION OF ACNE SEBUM ACCUMMULATION UNDER KERATINIC CAP DUCTAL HYPERCORNIFICATION OPEN COMEDONE = BLACK HEAD CLOSED COMEDONE = WHITE HEAD +

17. DERMAZELAN Closed comedoneOpen comedone Infected comedoneInflammed comedone

18. DERMAZELAN COMEDONE ALTERATION OF THE KERATINIZATION PROCESS QUANTITY & QUALITY CHANGES OF THE KERATIN PRODUCTION OF A KERATIN CAP INCREASING OF THE DUCTAL EPITELIUM TURN-OVER BLOCKAGE OF THE SEBUM PRODUCED

19. DERMAZELAN FOLLICULAR HYPERKERATOSIS Follicle duct full of keratin, sebum and bacterial micro-flora Keratinic epitelium that follows the upper epidermis Keratinization = cornification Same type of ripening that epidermis Quality & quantity alteration of the Keratinization Detachment of the corneocytes by an accumulative form

20. DERMAZELAN ABNORMAL KERATINIZATION

21. DERMAZELAN BACTERIAL MICRO-FLORA CHANGE Micro air atmosphere of the sebaceous glands Saprophyte micro-flora proliferation Increase of some bacterial enzymes production (lipases & proteases) Propionilbacterium Acnes and other micro-organisms Hydrolysis of the lipids by bacterial lipases fatty acids (F.A) F.A. with irritative and pro-inflammatory characteristics BCT INFECTIONS

22. DERMAZELAN COMEDONE CLOSEDOPENED CORNEOCYTES ACCUMMULATION + HYPERSEBORRHOEA

23. DERMAZELAN INFLAMMATORY ANSWERS PUS FREE RADICALS INFLAMMATION FOLLICLE WALLS BREACKAGE CELLULAR DETRITUS BCTR PUS IN- FLAMMATION +++ SURROUN- DING TISSUES

24. DERMAZELAN CLINICAL MANIFESTATIONS COMEDONES PAPULES NODES PUSTULES CISTES SCARS OPENED CLOSED NON INFLAMMATORY INFLAMMATORY OPEN COMEDONE CLOSED COMEDONE PUSTULECISTESPÁPULE PILOSEBAC. UNIT

25. DERMAZELAN ETHIOLOGY ( influencing factors ) HORMONES: puberty, menstrual cycles, hormonal fluctuations STRESS: hormonal repercussion, (suprarenal, hipotal./ hipofis.) BACTERIAL COLONISATION AND ALLERGIC ANSWERS DEAD CELLS ACCUMMULATION INSIDE THE GLANDS PORES STEROIDS DRUGS CLORATED COMPONENTS EXPOSITION ( cloroacne)

26. DERMAZELAN

27. Lesions get a severe stage Frequent septic manipulation Post acne scars

28. DERMAZELAN ANTIACNE TREATMENT Active ingredients group of chemical & natural nature The target of the ingredients are the 4 causes of acne Non medical or cosmetic treatment is giving an immediate result Synergic & polyvalent answers, combining ingredients Minor forms (comedones) have good results with an adequate cosmetic tr. Severe inflammatory forms may require medical treatment Cosmetic treatments are a good complement for the medical ones Sudden changes of the products can create irritative answers

29. DERMAZELAN ANTIACNE TREATMENT (Actions) SEBUM REGULATOR KERATOLITIC EXFOLIATOR DESPIGMENTATOR PORES DESCA- LORER SAPROFITE MICRO- FLORA INHIBITOR PURIFIER & IMPURITIES REMOVER MOISTURIZERER

30. DERMAZELAN

31. PRODUCT DESCRIPTION

32. DERMAZELAN

33. APPLICATION PROTOCOL REMOVE SEBUM EXCESS WITH DEGREASING SOLUTION APPLY MASK DURING 3 TO 6 HOURS APPLY MAINTENANCE CREAM MORNING AND NIGHT REMOVE MASK WITH SPONGES AND WATER CLEANSE THE SKIN WITH FACIAL GEL CLEANSER DAILY COMBINATION WITH SALYCILIC-PEEL 10% UNDER PROFS. CRITERIA COMBINATION WITH BLUE LIGHT PHOTOTHERAPIE OF PHOTOGEN S. 1 2 3 4 5 DAILY APPLY ROLL-ON OCCASIONAL TRTMNT SEVERAL TIMES 6

34. DERMAZELAN Thank you for your attention