1. Quiz – Page 38 1. Give 3 examples of a structural protein. 2. What class of protein in ferretin? 3. What does kinesin do? 4. What protein carries iron? 5. What class of protein is rhodopsin. collagen, elastin, tubulin, keratin,a ctin storage it interacts with microtubules to move organelles transferrin receptor

2. Proteins Homework due today!

3. Lesson 8– Catalysis

4. Nucleic Acids On your desks draw out the structure of a nucleic acid as you remember it.

5. Nucleotide Structure All nucleotides are made up of a pentose sugar, a phosphate group and a variable nitrogenous base.

6. Purines and Pyrimidines There are 2 types of nitrogenous bases – purines (double ring structures) and pyrimidines (single ring structures).

7. Uracil Uracil has one ring so it is a…. pyrimidine In fact it is structurally VERY similar to Thymine.

8. Nucleotide Structure Up Close

9. The Phosphodiester Bond A bond forms between the phosphate group (C5) of one nucleotide and the hydroxyl group (C3) on the sugar of another. The nucleotide monomers are joined by a dehyration synthesis reaction. Phosphodiester bond

11. Base Pairing On your desks write how the bases pair up. Indicate which are purines and which are pyrimidines. Purines always pair with pyrimidines. They are held together by hydrogen bonds. 3 bonds between C andG and 2 bonds between T and A (or U and A).

13. The Double Helix The 2 strands of the double helix are in an anti-parallel arrangement.

14. 3’ and 5’ 3’ is read “three prime” and refers to the third carbon on the sugar. Five prime refers to the 5 th.

15. Antiparallel Arrangement showing 3’ and 5’

16. Double Helix (again) Features of the DNS double helix: 1.One complete turn has a length of 3.4 nm. 2.The diameter of the molecule is 2.0 nm. 3.There is a major groove and a minor groove. 4.The helix is described as right handed.

17. RNA vs DNA List ways that DNA and RNA differ.

18. Polymerase Enzymes

19. DNA Ligase When describing proteins we can identify motifs and domains in the protein. Motif – a particular form of secondary structure. An examples include βαβmotif or βbarrel. Domains – regions of a polypeptide chain that fold independently to give distinct regions with potentially different roles

20. Your Task- Nucleic Acids 1. Past Paper Questions You will need to access these in the department. Please DO NOT TAKE past papers home – we have limited numbers. 2002 MC Q5 2004 MC Q12 2006 Section B Q1 2008 MC 5 2009 Q6 2. Complete Scholar activities on nucleic acids. 3. Read and make notes on pages 39-42. 4.Make sure your glossary is up to date. DUE Monday (November 26 th )