1. How to Assess for Early Psychosis Rachel Loewy, PhD UCSF Prodrome Assessment Research and Treatment (PART) Program

2. What is Early Psychosis? Schizophrenia as prototype (schizophrenia, schizoaffective, schizophreniform) Can include bipolar & unipolar depression Early = A) Recent onset psychotic disorders (within 3 yrs) B) at imminent risk for onset of psychosis

4. What do we mean by “Prodromal?” Webster’s Definition: An early symptom indicating the onset of a disorder Medical example: –Fever is prodromal to measles Prodromal definition in relation to psychosis: “Period preceding the onset of the first florid psychotic episode, when there is increasing symptomatic presentation and functional deterioration (NIMH).” Ultra-high-risk (UHR)

5. Model of Progression from Prodrome to Psychosis ChildhoodAdolescence Adulthood 3-5 yrs 1-3 yrs Psychosis No SxNon-specific Sx noticed by patient Sub-psychotic Sx affects functioning Treatment success Psychotic level Sx

6. Who is at ultra-high-risk for psychosis?

7. Symptoms in this stage include: Specific Symptoms: Positive Symptoms: experiences in excess of normal functioning Non-specific Symptoms: Negative Symptoms, Disorganization, Affective Symptoms – Cognitive – Social – Mood – Functioning Prodromal period of thought disorders

8. Structured Interview for Prodromal Syndromes (SIPS) Research diagnostic criteria 20% - 40% transition rate by 1 year Structured interview with patient and parents requires 2-3 hours

9. UHR Conversion Rates: NAPLS study (N=291) Months Full Psychosis Cannon, et al, 2008

10. 1)Attenuated Positive Symptom Prodromal Syndrome: One or more subthreshold positive symptoms, not fully psychotic in intensity: Unusual thought content /delusional ideas, suspiciousness/ persecutory ideas, grandiosity, perceptual abnormalities/distortions, conceptual disorganization. Currently present at a frequency of at least once per week, onset or worsening in the past year. Structured Interview for Prodromal Syndromes (SIPS)

11. 2) Brief Intermittent Psychosis Prodromal Syndrome: One or more fully psychotic symptoms: Hallucinations (auditory, visual, tactile, etc.), Delusions (thought broadcasting, thought insertion, paranoia, grandeur, etc.) and Formal thought disorder (loosening of associations, flight of ideas, etc.) Present intermittently for at least several minutes/day at least once per month, but less than 1 hour/ day, 4 days/week over 1 month. Structured Interview for Prodromal Syndromes (SIPS)

12. Structured Interview for Prodromal Syndromes (SIPS) 3) Genetic Risk and Deterioration Prodromal Syndrome: Precipitous decline in role functioning rated on the General Assessment of Functioning (GAF) scale as a drop of at least 30% in the past 12 months AND one of the following: Meets criteria for schizotypal personality disorder OR Has a family history of schizophrenia (psychotic disorder in a first-degree relative)

13. Unusual Thinking Confusion about what is real and what is imaginary Ideas of reference Preoccupation with the supernatural (telepathy, ghosts, UFOs) Other unusual thoughts: Mind tricks, nihilistic ideas, somatic ideas, overvalued beliefs, delusions of control

14. Suspiciousness Excessive suspiciousness, paranoid thinking Grandiosity Unrealistic ideas of special identity or abilities

15. Perceptual Disturbances Increased sensitivity to light and sound Hearing things that other people don’t hear Seeing things that others don’t see Smelling, tasting, or feeling unusual sensations that other people don’t experience

16. Difficulty getting the point across; trouble directing sentences towards a goal Rambling, going off track during conversations Incorrect words, irrelevant topics Odd speech Disorganized Communication

17. Negative Symptoms Wanting to spend more time alone Not feeling motivated to do things Trouble understanding conversations or written materials Difficulty identifying and expressing emotions

18. Disorganized Symptoms Neglect of personal hygiene Odd appearance or behavior Laughing at odd or inappropriate times Trouble with attention, clear thinking, comprehension

19. Impairment in Functioning Decline in functioning at school or work Problems in relationships with friends or family

20. Structured Interview for Prodromal Syndromes (SIPS) Positive Symptoms Scale: 0 Absent 1 Questionable 2 Subthreshold 3-5 Attenuated Range 6 Fully Psychotic

21. Structured Interview for Prodromal Syndromes (SIPS) 1.Onset: “When did (specific symptom) start?” 2. Duration of symptoms: “When (specific symptom) occurs, how long does it last?” 3. Frequency: “How often does (specific symptom) occur?”

22. Structured Interview for Prodromal Syndromes (SIPS) 4. Degree of Distress: What is this experience like for you? (Does it bother you?) Fully Psychotic = May be afraid/worried or may not. 5. Degree to which it interferes with life: Do you ever act on this experience? Do you ever do anything differently because of it? Fully Psychotic = They act on their belief. 6. Degree of Conviction/Meaning: How do you account for this experience? Do you ever feel that it could it just be in your head? Do you think this is real? Fully Psychotic = Not able to induce doubt.

23. Case Examples