1. The Endocrine System

2. Nervous System vs. Endocrine System Nervous System Endocrine System Speed of Action? How Long do the Effects Last? What is Used as a “Signal”? How Far Does the Signal Travel?

3. Hormones Hormones are _______________ produced and secreted by endocrine organs into the ___________. 2 Classes of Hormones: – 1. _____________ Hydrophilic or Hydrophobic? – 2. _____________ Hydrophilic or Hydrophobic?

4. Bloodstream Target Cell Endocrine Organ Protein Hormone Receptors cAMP

5. Figure 9.1b, step 1 Cytoplasm Nonsteroid hormone (first messenger) Receptor protein Plasma membrane of target cell

6. Figure 9.1b, step 2 Cytoplasm Nonsteroid hormone (first messenger) Enzyme Receptor protein Plasma membrane of target cell

7. Figure 9.1b, step 3 Cytoplasm Nonsteroid hormone (first messenger) Enzyme Receptor protein Second messenger Plasma membrane of target cell ATP cAMP

8. Figure 9.1b, step 4 Cytoplasm Nonsteroid hormone (first messenger) Enzyme Receptor protein Second messenger Effect on cellular function, such as glycogen breakdown Plasma membrane of target cell ATP cAMP

9. Endocrine Organ BloodstreamSteroid Hormone

10. Figure 9.1a, step 1 Nucleus Cytoplasm Steroid hormone Plasma membrane of target cell

11. Figure 9.1a, step 2 Nucleus Cytoplasm Steroid hormone Plasma membrane of target cell

12. Figure 9.1a, step 3 Nucleus Cytoplasm Steroid hormone Receptor protein Hormone-receptor complex Plasma membrane of target cell

13. Figure 9.1a, step 4 Nucleus Cytoplasm Steroid hormone Receptor protein Hormone-receptor complex DNA Plasma membrane of target cell

14. Figure 9.1a, step 5 Nucleus Cytoplasm Steroid hormone Receptor protein Hormone-receptor complex DNA mRNA Plasma membrane of target cell

15. Figure 9.1a, step 6 Nucleus Cytoplasm Steroid hormone Receptor protein Hormone-receptor complex DNA mRNA New protein Plasma membrane of target cell

16. Hormones Work by Negative Feedback

17. How Do Endocrine Glands Get Stimulated? Neural Stimulation Hormonal Stimulation Humoral Stimulation