1. Auburn University MRI Research Center

2. Facility Overview ● Three story – 45,000 SF building ● MRI systems ■ 3 Tesla (T) open-bore whole body ■ 7T whole body ● Designed to support research and clinical operations ■ Animal facilities Short-term holding facility Minimally-invasive procedures area ■ Training for faculty/staff/students ● Funded by a $21M State bond issued in 2007

3. Auburn University Objectives ● Increase AU research funding ■ Establish AU as a leader in MRI research ■ Enhance AU’s reputation as a major research university ■ Attract businesses/industries to the AU Research Park ● Provide additional healthcare capabilities for the region

4. AU MRI Research Center ● Partnership between ■ Auburn University ■ Siemens Healthcare ■ East Alabama Medical Center ■ Alabama Imaging Inc. ■ University of Alabama at Birmingham (UAB) ■ International Central South University (China) Siemens Corporate Technology (China)

5. Auburn Research Park

12. First Floor

13. Second Floor AU Research The Orthopaedic Clinic USAARL

14. Third Floor Rehab Works – EAMC AU Kinesiology Auburn Neurosurgery

15. Proposed Operating Scenario ● EAMC/AI controls 3T and clinical area ■ 8 hours/day (8AM-4PM) Mon-Fri ■ Lease at market value ● AU controls 3T ■ 16 hours/day (4PM-8AM) Mon-Fri ■ 24 hours/day Sat, Sun, holidays ● 7T is research only ■ AU control 24/7

16. Timeline ● June ‘09 – Order equipment ● July ‘09 – Building design ● July ‘09 – Begin seminar series ● Jan ‘10 – Begin construction ● Summer ‘10 – Begin training ● Sept ‘10 – Construction complete ● Oct ‘10 – 3T/7T install ● Oct ‘10 – Begin 3T operations ● Spring ‘11 – Begin 7T operations

17. Current and Potential Research Projects ● Coil design & Manufacture ■ Technology commercialization ■ Wireless technology ● Orthopedic Injury/Rehab ■ Auburn Athletics / Andrews Orthopedics ● fMRI/Cognitive Neuroscience ■ Autism ■ Psychology / Human Sciences ● Communication Disorders ■ Audiology ■ Speech Pathology ● Advanced cardiac imaging ■ UAB collaboration (NIH) ● Fat Imaging ■ Diabetes and obesity ● Metabolic/Molecular imaging ■ MRS/MRSI ■ Alzheimer’s disease (NIH)

18. 3T Open-Bore MRI ● FDA certified for clinical use ● 70 cm bore ● 173 cm length

19. 3T Open-Bore MRI

20. Standard Applications ● Neurology ● Angiography ● Cardiac ● Body ● Oncology ● Orthopedic ● Pediactric ● Scientific

21. Spine Imaging at 3T ● 4-channel neck coil ● 24-channel spine coil

22. Axially-Loaded Lumbar Spine MRI

23. Advanced Applications - DESS ● Increased cartilage/fluid contrast

24. Advanced Neuro Applications ● fMRI acquisition/analysis ● Diffusion ● Perfusion ● BOLD Imaging ● Advanced Functional Neuro

25. InVivo Esys fMRI System

26. 7T MRI

27. MAGNETOM UHF Community (22 sites): 1.Massachusetts General Hospital, Boston, USA Imaging since 08/2002 2.Institute for Neuro-Biology, Magdeburg, Germany Imaging since 02/2005 3.New York University, NYC, USA Imaging since 03/2005 4.Center for MR Research, Minneapolis, USA Imaging with Siemens console since 12/2005 5.Gachon Medical School, Seoul, Korea Imaging since 04/2006 6.Oregon Health, Portland, USA First images 12/06 7.Erwin Hahn Institute for Magnetic Resonance, Essen, Germany Imaging since 09/2006 8.Center for Imaging in Biomedicine, Lausanne, Switzerland Imaging since 11/2006 9.Max Plank Institute, Tübingen, Germany (9.4T)  Imaging since 07/2007 10.CEA, Paris, France  Imaging since 02/2007 11.CEA, Paris, France, 11.7T  to be installed 2013 12. UPMC, Pittsburgh, USA former GE system converted to Siemens Imaging since 05/2007 13. Max Plank Institute, Leipzig, Germany Imaging since 07/2007 14. Medical University of Vienna, Vienna, Austria Imaging since 04/2008 15. DKFZ, Heidelberg, Germany Imaging since 08/2008 16. Forschungszentrum Jülich, Germany (9.4T/900) Imaging since 17. HUP, Philadelphia, PA, USA Imaging since 06/2008 18. MDC, Berlin, Germany Imaging since 12/2008 19. CAS, Beijing, China To be installed in Fall 2009 20. Oxford University, Oxford, UK To be installed in spring 2010 21. Auburn University, Auburn, Alabama, USA To be installed Fall 2010 22. CMRR, Minneapolis, USA To be installed in fall 2010

28. Other Siemens 7T Installations in USA ● MGH/ Harvard/ MIT ● NYU ● Penn ● Minnesota ● Portland, Oregon ● Pittsburgh

29. High-Field Imaging T2-weighted imaging of the human hippocampus 1.5T7.0T

30. Functional MRI (fMRI)

31. Van der Zwaag, et al, Neuroimage. 2009 May 14 fMRI at 1.5T, 3.0T, 7.0T

32. Van der Zwaag, et al, Neuroimage. 2009 May 14 fMRI at 1.5T, 3.0T, 7.0T

33. 7.0T1.5T Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7

34. 7.0T1.5T Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7

35. Spatial Resolution 3T7T fMRI BOLD3.0 / 2.5 mm 6 0.5 / 3.0 mm 3 Brain 0.5 / 1.0 mm 7 1.0 / 1.0 mm 7 0.05 / 2.0 mm 4 0.7 / 0.7 mm 5 Musculoskeletal0.30 / 2.0 mm 2 0.15 / 1.0 mm 1 1.Regatte, et al, JMRI Vol.25, 2 Pages: 262-269 2.Kuhl, et al, Radiology. 2008 Apr;247(1):16-35 3.Yacob, et al, Neuroimage. 2007 October 1; 37(4): 1161–1177 4.Nakada, Brain and Development,29 (6), July 2007, 325-335 5.Thomas, et al, JMRI 2008 November; 28(5): 1266–1272 6.Miller, et al, J Neurophysiol 99:1969-1982, 2008 7.Wiggins, et al, Magn Reson Med, 56(1), 216-223, 2006

36. Spectroscopy ● Proton spectroscopy (3T and 7T) ■ Single voxel ■ Chemical shift imaging ● Multinuclear spectroscopy (7T only) ■ 7 Li, 13 C, 17 O, 19 F, 23 Na, 31 P

37. MRI - Coils

38. Small Rodent MRI

39. Small Animal MRI

40. Fat Imaging

41. Fat Detection & Quantification