3. Multicenter, randomized, double-blind low-dose vasopressinNorepinephrine 396 patients 382 patients 28 day mortality

5. Multicenter, randomized trial DopamineNorepinephrine 858 patients 821 patients 28 day mortality

9. July 3, 2008 Multicenter, randomized trial 1 mg of epinephrine and 40 IU of vasopressin 1 mg of epinephrine and saline placebo 1442 patients 1452 patients Survival to hospital admission

11. December 18, 2008 Multicenter, randomized double-blind trial Tenecteplaseplacebo 525 patients 30 day Survival terminated early for futility

12. (relative risk of survival, 0.87; 95% confidence interval, 0.65 to 1.15; P = 0.36)

13. June 5, 2008 Multicenter, randomized international trial Hypothermia GroupNormothermia Group (N = 108) (N = 117) Death or severe disability at 18 months of age

15. October 1, 2009 Multicenter, randomized trial Intensive care with cooling,Intensive care only (N = 163) (N = 162) Death or severe disability at 18 months of age

17. July 10,, 2008 Multicenter, open, prospective, randomized, controlled trial Standard oxygen therapyCPAP NIPPV (N = 367) (N = 346) (N = 356) Death or intubation within 7 days

21. Multicenter, randomized trial Continuous renal-replacement therapy in the form of postdilution continuous venovenous hemodiafiltration with different effluent flower intensity 40 ml per kilogram per hour (higher intensity) 25 ml per kilogram per hour (lower intensity). (N = 747) (N = 761) Death after 90 days

27. Multicenter, randomized, controlled trial Intensive glucose control Target range of 81 to 108 Conventional glucose control Target of 180 mg or less (N = 3054) (N = 3050) Death after 90 days

33. January 1,, 2009

34. Multicenter, randomized, crossover trial Selective digestive tract decontamination (SDD) Selective oropharyngeal decontamination (SOD) Standard Therapy 204519041990 28 day mortality

35. Multicenter, randomized, double-blind, placebo-controlled InterventionControl 251 patients received 50 mg of intravenous hydrocortisone every 6 hours for 5 days 248 patients to receive placebo every 6 hours for 5 days 28 day mortality

40. Open-Label Randomized Trial Chlorhexidine Control 250 Patients262 Patients Effects on the incidence of nosocomial pneumonia during ICU stay

42. Retrospective Analysis Pantoprazole Ranitidine 377 Patients457 Patients Incidence of nosocomial pneumonia during ICU stay

44. Chest 2010;137;544-551

45. seven RCT studies that included 11,425 patients.

48. Intervention Control Chlorhexidine gluconate– impregnated sponge ( CHGIS) Standard Dressing Every 7 days Every 3 Days Every 7 days Every 3 Days 413 Patients 412 Patients 416 Patients Major CRIs for comparison of CHGIS vs control dressings; colonization rate for comparison of 3- vs 7-day dressing changes.

50. Prospective, double-blind, randomized trial DexmedetomidineMidazolam RASS -2-+1 250 Patients 125 Patients Percentage of time within target RASS range.

55. JAMA, March 3, 2010—Vol 303, No. 9

58. JAMA. 2010;303(8):739-746

59. Multicenter randomized, non-inferiority trial ScvO2 Group Lactate Clearance Group Resuscitated to normalize central venous pressure, mean arterial pressure and ScvO2 of at least 70%; Resuscitated to normalize central venous pressure, mean arterial pressure, and lactate clearance of at least 10%. 150 Patients In-hospital mortality rate

63. Prospective, multicenter, randomized controlled trial Conventional therapy plus 2 sessions of polymyxin B hemoperfusion Conventional Therapy 34 Patients 30 Patients Change in MAP and vasopressor requirement

66. Multicenter, unblinded, randomized controlled trialSupineProne 174 Patients 168 Patients 28-day all-cause mortality JAMA. 2009;302(18):1977-1984

68. Multicenter, multicenter, 22 factorial, randomized trial Insulin infusion with hydrocortisone alone Insulin infusion with hydrocortisone plus fludrocortisone, Conventional insulin therapy with hydrocortisone alone Conventional insulin therapy with intravenous hydrocortisone plus fludrocortisone. 509 Patients In-hospital mortality The COIITSS Study Investigators JAMA. 2010;303(4):341-348

73. Crit Care Med 2009 Vol. 37, No. 6

74. Crit Care Med 2009 Vol. 37, No. 9

76. Crit Care Med 2010 Vol. 38, No. 4

77. Avoid

78. Prospective, randomized, clinical study Nasodudenal Feeding Nasogastric Feeding 59 Patients 62 Patients Optimal nutritional support assessed by measurement of time to goal tube feed rate and daily calorie and protein intake. Crit Care Med 2009 Vol. 37, No. 6

80. Crit Care Med 2009 Vol. 37, No. 2 Total cohort number 66,184

82. Crit Care Med 2010 Vol. 38, No. 3 Prospective multicenter cohort study Candida glabrata fungemia Nonglabrata fungemia. 48 Patients 106 Patients Independent Risk Factors

85. Crit Care Med 2009 Vol. 37, No. 5

89. Crit Care Med 2010 Vol. 38, No. 2

90. 155/255 survival 61%

91. Crit Care Med 2009 Vol. 37, No. 3 Prospective, randomized, open, multicenter study setting, 12 French intensive care units. Hemofiltration (25 mL/kg/hr) for a 96- hour period, Conventional treatment 37 Patients 39 Patients Number, severity, and duration of organ failures during 14 days

93. Crit Care Med 2009 Vol. 37, No. 9

94. Overall, 22% (n 71,486) of patients developed acute kidney injury (Stage I: 17.5%; Stage II: 2.4%; Stage III: 2%) Odds of death associated with AKI in ICU

95. Crit Care Med 2010 Vol. 38, No. 2

96.  The need for early serial IAP monitoring when IAH/ACS risk factors are present  Improving abdominal wall compliance through sedation, analgesia, and pharmacologic paralysis  Evacuating intraluminal contents through nasogastric or rectal decompression  Evacuating abdominal fluid collections via percutaneous drainage  Correcting positive fluid balance through the use of hypertonic fluids, colloids, and careful diuresis  Supporting organ function vasopressors and judicious goal- directed fluid resuscitation to maintain an abdominal perfusion pressure (calculated as mean arterial pressure IAP) 60 mm Hg  Early surgical intervention when IAP exceeds 25 mm Hg

98. Crit Care Med 2009 Vol. 37, No. 2

99. ScoreVariablesPoints PredispositionCOPD or Immunosuppression 1 Age > 70 ys1 InsultBacteremia1 Multilobar opacities on radiograph 1 ResponseShock1 Severe hypoxemia1 Organ dysfunctionAcute renal failure1 Respiratory distress syndrome 1 Critical Care Medicine: February 2009 - Volume 37 - Issue 2 - pp 456-462 Range 0-8 points

100. Critical Care Medicine: February 2009 - Volume 37 - Issue 2 - pp 456-462 HOME HOSPITAL ICU ?CARE

101. Crit Care Med 2009 Vol. 37, No. 8

107. Crit Care Med 2009 Vol. 37, No. 9

109. Crit Care Med 2009 Vol. 37, No. 5

110. 24%

111. Crit Care Med 2009 Vol. 37, No. 1

113. Crit Care Med 2010 Vol. 38, No. 2

116. Crit Care Med 2009 Vol. 37, No. 4 Randomized, double-masked, placebo-controlled, single-center clinical trial Low dose continuous infusion of unfractioned heparin (500 units/hour for 7 days) Placebo 159 Patients 160 Patients 28 day mortality

118. Crit Care Med 2009 Vol. 37, No. 5

121.  Total parenteral nutrition X1  Surgery X1  Multifocal Candida colonization X1  Severe sepsis X 2.