1. TCGA(The cancer genome atlas) catalogue genetic mutations responsible for cancer, using genome sequencing and bioinformatics The TCGA is sequencing the entire genomes of some tumors, including at least 6,000 candidate genes and microRNA sequences

2. 2014 The Somatic Genomic Landscape Of Chromophobe Renal Cell Carcinoma Cancer Cell. Published online 21 Aug. 2014 Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin Cell. Published online 07 Aug. 2014 Comprehensive Molecular Characterization of Gastric Adenocarcinoma Nature. Published online 23 July 2014 Comprehensive molecular profiling of lung adenocarcinoma Nature. Published online 09 July 2014 Comprehensive molecular characterization of urothelial bladder carcinoma Nature. 507 (7492):315-22. 2013 The Somatic Genomic Landscape of Glioblastoma Cell. 155 (2):462-477. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 499 (7456):43-49 Integrated genomic characterization of endometrial carcinoma. Nature. 497 (7447):67-73. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. NEJM. 368:2059-2074 2012 Comprehensive molecular portraits of human breast tumors. Nature. 490 (7418):61-70. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 489 (7417):519:525 Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487 (7407):330-337. 2011 Integrated genomic analyses of ovarian carcinoma. Nature. 474 (7353):609-615. 2010 Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell. 17 (5):510-522 An integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1. Cancer Cell. 17 (1):98-110 2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 455 (7216):1061-1068 The Cancer Genome Atlas Research Network Publications

3. Development of the molecular classification of gastric cancer and to identify dysregulated pathways and candidate drivers of distinct classes of gastric cancer Classification of gastic cancer

4. Array-based somatic copy number analysis : SNP-based copy number analysis Whole exome sequencing Array based DNA methylation profiling mRNA seq miRNA seq Reverse-phase protein array(RPPA) Molecular platform From 295 patient tumor sample

7. Define of a molecular subtypes of gastric cancer SCNA : somatic copy number aberration

8. pa Molecular characteristics of EBV-positive gastric cancers pathseq algorithm : human reference genome/ microbial reference genome(including bactorial, viral, archaeal, fungal)

9. Significantly mutated genes in non-hypermutated gastric cancer

10. RHOA(Ras homologue gene family, member A) Small GTPase protein known to regulate the actin cytoskeleton in the formation of stress fivers RhoA has been found to be hyper activated in gastric cancer cells RHOA mutation were enriched in the genomically stable subtype (15% of genomically stable cases, p=0.0039) RhoA activity has been linked within several cancer applications due to its significant involvement in cancer signaling cascades RHOA and ARHGAP6/26 somatic genomic alterations are recurrent in genomically stable gastric cancer

11. Whole exome-seq(107 tumours)  5696 structural rearrangement (74 predicted, in-frame gene fusion) De novo assembly of mRNA seq data  170 structural rearrangement ARHGAP26(GRAF) GTPase-activating protein(GAP), RHO GTPase  GDP CLDN78 Component of the tight junction adhesion structure RHOA and ARHGAP6/26 somatic genomic alterations are recurrent in genomically stable gastric cancer

12. Integrated molecular description of gastric cancer

13. Key features of gastric cancer subtype