1. Wnt/β-catenin pathway Seminar Spring 2011 Maneeshi Prasad 21st Jan 2011 Man

2. Wnt pathway Ligands Receptors Intracellular components Transcription factors Interactome

3. Wnt “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes Wnt are secreted proteins 19 Wnt genes in humans and mice

4. Wnt Receptors Receptor tyrosine kinase Derailed/RYK ROR Frizzled-transmembrane receptor LRP (lipoprotein-receptor related protein) Single-pass Tm proteins Cytoplasmic tail phosphorylated by GSK3 and CK1  http://www.stanford.edu/group/nusselab/cgi-bin/wnt/main#Diagrams

5. Wnt Pathway

6. Wnt signaling

7. Interactions: Intracellular Components

8. Intracellular Components

9. Canonical/Non-canonical Wnt pathway

10. Wnt Pathway Interactome

11. Wnt pathway interactions

12. Role of Wnt signaling

13. Development Neural development: CNS Neural crest Limb Tumor formation Cellular growth and proliferation